Pharmacokinetics of levofloxacin mesylate in healthy adult giant panda after single‐dose administration via different routes

Abstract

The pharmacokinetics of levofloxacin mesylate in healthy adult giant panda is unknown. In this study, the pharmacokinetics of levofloxacin after intramuscular administration at a dose of 2 mg/kg and oral administration at a dose of 3 mg/kg in healthy adult giant pandas was determined. Levofloxacin concentrations in plasma were determined using liquid chromatography. In the levofloxacin intramuscular administration group, the absorption and elimination half‐lives of the drug were determined to be 0.123 (range: 0.02) hr and 5.402 (range: 0.70) hr, respectively. In the levofloxacin oral administration group, the absorption and elimination half‐lives were determined to be 0.325 (range: 0.02) hr and 7.143 (range: 0.63) hr, respectively. Furthermore, the blood–drug concentration of levofloxacin was found to be above 1 μg/ml after 8 hr of intramuscular administration and above 0.5 μg/ml after 12 hr of oral administration. In this study, HPLC conditions and pretreatment methods of plasma samples were optimized and a detection method was established. Our results indicated that in healthy adult giant pandas, levofloxacin was rapidly absorbed and slowly eliminated. This study will therefore provide to be a guide in veterinary research and will be helpful in the rational use of levofloxacin in giant panda.

Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

“…Over 60 years old in patients receiving levofloxacin there was a higher incidence of adverse reactions to prevent infection treatment mainly includes: the main reasons for elderly patients with viscera function decline, easily complicated by a variety of disease, and levofloxacin by kidney metabolism, effects on kidney burden, clinical applications in the old people should take into consideration the reduction and regular monitoring of kidney function [31]. In addition, from the animal experiments on quinolone antibiotics, it was found that young animals taking quinolone antibiotics would produce cartilage damage to joint tissue, so children, pregnant and lactating women should be forbidden levofloxacin [32][33][34][35]. At the same time, because levofloxacin belongs to quinolones antibiotic effect, from this group of cases cure effect and ADRs of reaction after taking levofloxacin, static drop 1-or 2-times daily fee sand star of left oxygen drugs for prevention of postoperative infection, there was no significant difference, and oxygen cost effect of medication to reduce the incidence of ADR is safer and more effective [36][37][38][39].…”