2022
DOI: 10.1016/j.aquaculture.2021.737356
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Pharmacokinetics of magnolol following different routes of administration to goldfish (Carassius auratus) and its oral efficacy against Ichthyophthirius multififiliis infection

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Cited by 9 publications
(7 citation statements)
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“…During the whole study, the water temperature was maintained at 30°C, thus, the withdrawal period can also be expressed as 450°C-day. Coincidentally, the same withdrawal period has been reported in northern snakehead (Zhang, Cui et al, 2021;Zhang, Wang et al, 2021) after multiple oral doses of ENR at 10 mg/kg bw daily for 5 days, for which, the calculated withdrawal period of ENR and CIP was 18 days (450°C-day). However, the withdrawal period varied greatly among different fish species, dosing regimens and environmental conditions.…”
Section: F I G U R Esupporting
confidence: 74%
See 1 more Smart Citation
“…During the whole study, the water temperature was maintained at 30°C, thus, the withdrawal period can also be expressed as 450°C-day. Coincidentally, the same withdrawal period has been reported in northern snakehead (Zhang, Cui et al, 2021;Zhang, Wang et al, 2021) after multiple oral doses of ENR at 10 mg/kg bw daily for 5 days, for which, the calculated withdrawal period of ENR and CIP was 18 days (450°C-day). However, the withdrawal period varied greatly among different fish species, dosing regimens and environmental conditions.…”
Section: F I G U R Esupporting
confidence: 74%
“…For fish, there are three main routes of administration of ENR, namely injection, oral administration and bath. Injection and oral gavage can guarantee accurate dosing, but they are impractical due to high labor costs and stress on the fish (Kent, 2015; Zhang, Cui et al., 2021; Zhang, Wang et al., 2021). Medicated feed was often preferred in situation where most of the fish are able to eat, but actual dose intake could not be ascertained (Kent, 2015; Rairat et al., 2020; Terzi et al., 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Honokiol and magnolol are the main active ingredients of M. officinalis (Ho et al, 2001; Lee et al, 2011; Lin et al, 2021). Besides the antibacterial activity, our previous studies also revealed their antiviral (Chen et al, 2017), antiparasitic (Zhang et al, 2022; Zhong et al, 2019) and antifungal (Hu et al, 2019) effects in various fish species. However, the antibacterial activity against N. seriolae has not yet been studied, and an attempt has been made under the present work to screen medicinal plants and their bioactive compounds with potent antibacterial activity against N. seriolae infection.…”
Section: Introductionmentioning
confidence: 91%
“…Previous studies showed that the LC 50 ‐ (96 h) of magnolol to goldfish was 6.02 mg/L (Song et al, 2018). Furthermore, pharmacokinetic results showed that the magnolol in the major organs was hard to detect after 72 h post‐oral feeding (Zhang et al, 2021). However, systematic safety evaluation of feeding of magnolol is still unclear.…”
Section: Introductionmentioning
confidence: 99%