Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches

Lucas, J. J. De; Rodríguez, C.; Waxman, Samanta; González, F.; Uriarte, Isabel; Andrés, M. I. San

doi:10.1016/j.tvjl.2004.06.012

Cited by 30 publications

(26 citation statements)

References 19 publications

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“…The obtained value was close to that recorded by Anadon et al. , 2002 in broiler (0.77 L/kg) and lower than those reported in ostriches and turkey (De Lucas et al. , 2005 and Haritova et al.…”

Section: Mean ± Sd Plasma Pharmacokinetic Parameters Of Marbofloxacisupporting

confidence: 82%

The disposition of marbofloxacin after single dose intravenous, intramuscular and oral administration to Muscovy ducks

Goudah

Hasabelnaby

2010

Vet Pharm & Therapeutics

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Section: Mean ± Sd Plasma Pharmacokinetic Parameters Of Marbofloxacisupporting

confidence: 82%

The disposition of marbofloxacin after single dose intravenous, intramuscular and oral administration to Muscovy ducks

Goudah

Hasabelnaby

2010

Vet Pharm & Therapeutics

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“…In addition to that in pigs, marbofloxacin pharmacokinetics have been investigated in other species. After intramuscular injection, the t 1/2λz was 1.96, 3.15, 3.65, 7.16, 7.72, and 17.50 h in ostriches [4], ducks [8], sheep [15], camels [11], rabbits [13], and calves [17], respectively. These results indicate that the elimination of marbofloxacin from pigs is slower than that in other species.…”

Section: Discussionmentioning

confidence: 99%

Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Yang

Liu

et al. 2017

J Vet Sci

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Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t1/2λz) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to ∞ (AUC0–∞s) were calculated to be 31.17 h·µg·mL−1 for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 h·µg·g−1 for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (Cmax) of marbofloxacin was 1.62 µg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 µg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.

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“…, 2006), Eurasian buzzards (Garcia‐Montijano et al. , 2006), ostriches (De Lucas et al. , 2005), and broiler chickens (Anadon et al.…”

Section: Introductionmentioning

confidence: 99%

Influence ofPasteurella multocidainfection on the pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in rabbits

Abo‐EL‐Sooud

Goudah

2010

Journal of Veterinary Pharmacology and Therapeutics

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The pharmacokinetic behavior of marbofloxacin was studied in healthy (n = 12) and Pasteurella multocida infected rabbits (n = 12) after single intravenous (i.v.) and intramuscular (i.m.) administrations. Six rabbits in each group (control and diseased) were given a single dose of 2 mg/kg body weight (bw) of marbofloxacin intravenously. The other six rabbits in each group were given the same dose of the drug intramuscularly. The concentration of marbofloxacin in plasma was determined using high-performance liquid chromatography. The plasma concentrations were higher in diseased rabbits than in healthy rabbits following both routes of injections. Following i.v. administration, the values of the elimination half-life (t(1/2beta)), and area under the curve were significantly higher, whereas total body clearance was significantly lower in diseased rabbits. After i.m. administration, the elimination half-life (t(1/2el)), mean residence time, and maximum plasma concentration (C(max)) were higher in diseased rabbits (5.33 h, 7.35 h and 2.24 microg/mL) than in healthy rabbits (4.33 h, 6.81 h and 1.81 microg/mL, respectively). Marbofloxacin was bound to the extent of 26 +/- 1.3% and 23 +/- 1.6% to plasma protein of healthy and diseased rabbits, respectively. The C(max)/MIC (minimum inhibitory concentration) and AUC/MIC ratios were significantly higher in diseased rabbits (28 and 189 h) than in healthy rabbits (23 and 157 h), indicating the favorable pharmacodynamic characteristics of the drug in diseased rabbits.

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Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches

Cited by 30 publications

References 19 publications

The disposition of marbofloxacin after single dose intravenous, intramuscular and oral administration to Muscovy ducks

The disposition of marbofloxacin after single dose intravenous, intramuscular and oral administration to Muscovy ducks

Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Influence ofPasteurella multocidainfection on the pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in rabbits

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