2017
DOI: 10.1007/s40261-017-0610-4
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetics of Oral and Intravenous Paracetamol (Acetaminophen) When Co-Administered with Intravenous Morphine in Healthy Adult Subjects

Abstract: Background and ObjectiveSeveral features favor paracetamol (acetaminophen) administration by the intravenous rather than the oral route in the postoperative setting. This study compared the pharmacokinetics and bioavailability of oral and intravenous paracetamol when given with or without an opioid, morphine.MethodsIn this randomized, single-blind, parallel, repeat-dose study in healthy adults, subjects received four repeat doses of oral or intravenous 1000 mg paracetamol at 6-h intervals, and morphine infusio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
36
0
1

Year Published

2018
2018
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 37 publications
(37 citation statements)
references
References 21 publications
0
36
0
1
Order By: Relevance
“…Paracetamol (acetaminophen) is a very common antipyretic and analgesic agent. It is well absorbed after oral administration, with bioavailability of 70–90% attributable to first pass metabolism [17,18,19]. Paracetamol is also the analgesic/antipyretic drug of choice for bariatric patients, who should avoid non-steroidal anti-inflammatory drugs (NSAIDs) due to increased risk of bleeding and ulcerations.…”
Section: Introductionmentioning
confidence: 99%
“…Paracetamol (acetaminophen) is a very common antipyretic and analgesic agent. It is well absorbed after oral administration, with bioavailability of 70–90% attributable to first pass metabolism [17,18,19]. Paracetamol is also the analgesic/antipyretic drug of choice for bariatric patients, who should avoid non-steroidal anti-inflammatory drugs (NSAIDs) due to increased risk of bleeding and ulcerations.…”
Section: Introductionmentioning
confidence: 99%
“…However, when IV APAP was co-administered with IV morphine, pharmacokinetics of APAP were not impacted. Additionally, there was an abrupt increase in peak concentration and area under the curve following discontinuation of IV morphine in the oral APAP group [ 20 ]. When acetaminophen is co-administered with morphine, the IV formulation produces more predictable blood levels compared to the oral formulation, which shows increased inter-individual pharmacokinetic variability [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…The benefits of oral acetaminophen, when used in conjunction with narcotic pain medications, have a limited efficacy in our postoperative patient population secondary to impaired absorption as well as altered pharmacokinetics when given in conjunction with intravenous morphine. 19 , 20 Furthermore, adequate absorptive capacity of the gastrointestinal tract and the availability of an oral route for medication administration may be limited even further depending on the type of surgery performed. Further limiting this patient population is the inability to use nonsteroidal anti-inflammatory drugs, as a consistent method of pain relief in our LRYGB patients.…”
Section: Discussionmentioning
confidence: 99%