Pharmacokinetics of orally administered norethisterone enanthate in rabbit, monkey, and women

Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms

“…Previous research into progestogen metabolism has been limited and has typically focused on measuring the serum or urine concentrations of progestogens and/or their metabolites in a clinical setting [19][20][21][22][23][24][25][26]. In this work we investigated, for the first time, the cell-and steroidspecific metabolism of a range of clinically-relevant steroids using in vitro cell line models.…”

Insights into the fatty acid ester norethisterone enanthate binding to human albumin: fluorescence, circular dichroism, and docking investigations

“…NET-EN is also biologically active and effective in inhibiting fertility if taken orally. 22 Aer absorption, NET-AC is rapidly and completely deacetylated to NET, but NET-EN is stored and slowly released. Finally, NET-AC and NET-EN are hydrolyzed to NET mainly in the liver with the help of the bloodstream because neither muscle nor plasma causes signicant breakdown of ester in humans.…”

“…20 In-depth understanding and analysis of NET-EN and its interaction with HSA are essential and will signicantly promote medical purposes. [21][22][23] In the present work, crystalline NET-EN was obtained and studied by single crystal X-ray diffraction. This study is necessary for the better understanding of NET-EN from the atomic level.…”

X-ray powder diffraction data for norethisterone enanthate, C27H38O3

“…Norethisterone enanthate (Figure 1), a fatty acid ester of norethisterone, is a widely used long-acting intramuscular depot contraceptive drug (Ravinder et al, 1997). It can prevent conception by inhibiting ovulation.…”