Pharmacokinetics of oxytetracycline in black tiger shrimp, Penaeus monodon, and the effect of cooking on the residues

Uno, Kazuaki; Aoki, Takahiko; Kleechaya, Walai; Tanasomwang, Varin; Ruangpan, Lila

doi:10.1016/j.aquaculture.2005.10.031

Cited by 49 publications

(42 citation statements)

References 32 publications

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“…The analytical procedures were previously described (Uno et al, 2006). Briefly, hemolymph samples were filtered through 0.45-lm disposable syringe filter units equipped with cellulose acetate membranes (Advantec, Tokyo, Japan).…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…It has potential for use in farm-raised shrimp for the treatment of vibriosis like Vibrio alginolyticus and Vibrio harveyi. There are many studies on the pharmacokinetics and residues of OTC in marine and freshwater shrimp (Mohney et al 1997;Bermúdez-Almada et al 1999;Brillantes et al 2001;Uno 2002Uno , 2004Sangrungruang et al 2004;Reed et al 2004Reed et al , 2006Weifen et al 2004;Uno et al 2006;Poapolathep et al 2008a, b), but limited information of OTC dispositions in P. vannamei is available (Chiayvareesajja et al 2006;Nogueira-Lima et al 2006;Faroongsarng et al 2007;Gómez-Jimenez et al 2008). …”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a twocompartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 lg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 lg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20-50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to [80%, while those were reduced to around 30% by alkaline treatment.

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Section: Analytical Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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“…It is known that OTC forms complexes with di-cation, such as Ca 2+ and Mg 2+ , in hard tissues of fish (Grondel et al, 1987;Jacobsen, 1989;Rogstad et al, 1991;Namdari et al, 1996;Malvisi et al, 1996;Maruyama and Uno, 1997). In our previous works, Ca-tetracycline chelates accumulated in shrimp shells and were shown to be considerably stable (Uno et al, 2006a). Therefore, it is probable that the Ca-tetracycline chelates were almost all released from carapaces and shells into the hydrochloric acid solution.…”

Section: Chitin Yields From Carapace and Shellmentioning

confidence: 90%

“…The extraction method of OTC was previously described (Uno et al, 2006a;2010). Briefly, samples (0.5 g) were homogenized with 30 ml of 5% trichloroacetic acid containing 0.5% EDTA and centrifuged for 20 min at 12,000 rpm.…”

Section: Analytical Proceduresmentioning

confidence: 99%

Untitled

Uno¹,

Higashimoto²,

Chaweepack³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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The present study examined the influences of industrial chitin extraction processes on the residual oxytetracycline (OTC) and oxolinic acid (OA) in shrimp carapaces and shells. The drugs were orally administered by catheter to the kuruma shrimp (Penaeus japonicus) and vannamei shrimp (Penaeus vannamei). The shrimps were sampled at 6-h post-dosing and their carapaces and shells were collected and used as raw material in the chitin extraction. Residual OTC levels in raw materials were 9 -18 fold higher than the maximum residue limit (MRL) (0.2 µg/g). The residual OTC was reduced 10 -30% by washing treatment. By the acid treatment with HCl, the OTC residues were reduced >98%. The deproteinized material contained negligible levels of OTC. Residual OA levels in raw materials was much higher (134 -376 fold) than the MRL (0.03 µg/g). The residual OA was reduced considerably (34 -68%) by washing treatment. By the demineralization, the residual OA could not be detected in both shrimp carapaces, while the levels of OA residues were determined more than MRL in shells. In the deproteinized materials, no residual OA were detected. Finally, residual OTC and OA could not be detected in the chitin materials for both shrimps.

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“…Although residual drugs may be degraded by cooking procedures to some degree (XU et al, 1996;UNO et al, 2006) and inactivated to a variable extent in the intestines by decomposition of bacterial enzymes and by binding to bacteria and other faecal components, the possibility of inducing alteration of the intestinal flora and disruption of the colonization barrier is not unlikely ( VAN DER WAAIJ, 1982;EDLUND & NORD, 1993;VOLLARD & CLASENER, 1994;CERNIGLIA & KOTARSKI, 1999;EDLUND & NORD, 1999). Human intestinal microflora constitute a balanced and complex community inhabited by hundreds of bacterial species (CERNIGLIA & KOTARSKI, 1999) which are vital for the maintenance of a healthy human gastrointestinal tract since they inhibit colonization of pathogenic bacteria (VOLLARD & CLASENER, 1994) and intervene in the digestion and processing of various substances (CHADWICK et al, 1992).…”

Section: Residual Antibacterials In Aquatic Farmed Items; Possible Efmentioning

confidence: 99%

Antibacterial drugs in products originating from aquaculture: assessing the risks to public welfare

2010

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As aquaculture expands to meet human demand and compensate for pessimistic forecasts of fisheries catches, use of antibacterial agents to combat or forestall bacterial diseases is still a necessity, although effective vaccines and improved hygiene have aided drastically in this battle. The hazards for the consumer perspective arising from the imprudent use of such chemicals can be detrimental, especially if the residues persist above legal tolerance. These may include selection and dissemination of resistant bacteria, disruption of the colonization barrier in the human intestinal flora and allergic reactions. In cases that unlawful drugs reached the consumer via consumption of aquatic products, human health may be jeopardized even further. The present review article assesses these risks to human health.

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Pharmacokinetics of oxytetracycline in black tiger shrimp, Penaeus monodon, and the effect of cooking on the residues

Cited by 49 publications

References 32 publications

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

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Antibacterial drugs in products originating from aquaculture: assessing the risks to public welfare

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