Pharmacokinetics of phenylbutazone in healthy subjects after oral administration of single and multiple doses

Sioufi, A.; Colussi, D.; Caudal, F.; Schoeller, JP; Massias, P

doi:10.1002/jps.2600691216

Cited by 10 publications

(1 citation statement)

References 9 publications

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“…Most cases of phenylbutazone toxicity are treated similar to other NSAID poisoning with supportive therapy, including airway management, volume resuscitation, and correcting for metabolic acidosis. As with other NSAID toxicities, dialysis has not been shown to be an effective treatment option as it is highly protein-bound [ 5 ]. Activated charcoal of 25–100 g in adolescents/adults or gastric lavage have also been used if the patient presents within 1 h of ingestion.…”

Section: Discussionmentioning

confidence: 99%

“Ain’t She a Bute?”: The Importance of Proper History Taking in a Case of Inappropriate Use of Horse NSAID in a Human

Sawalha

James

Mazahreh

et al. 2021

Clinics and Practice

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A 41-year-old woman with no significant past medical history presented to the hospital with complaints of nausea, vomiting, and generalized weakness over two weeks. The patient did not seek medical attention as she assumed that her symptoms willwould resolve. Following her initial denial of drug abuse and her abnormal urine drug screening, we discussed the findings with the patient. She later admitted to using both amphetamines and marijuana. This led us to take a detailed social history that revealed an unexpected event.

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Section: Discussionmentioning

confidence: 99%

“Ain’t She a Bute?”: The Importance of Proper History Taking in a Case of Inappropriate Use of Horse NSAID in a Human

Sawalha

James

Mazahreh

et al. 2021

Clinics and Practice

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Bioavailability of phenylbutazone from a new enteric‐coated formulation with superior dissolution characteristics

John¹,

Goldsborough²,

Morrison

et al. 1982

Biopharm & Drug Disp

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The bioavailability of an improved formulation of enteric-coated phenylbutazone with faster dissolution, more consistent in vitro rate of drug release and improved stability was compared in 8 normal subjects at doses of 100 and 200 mg with commercially available Butacote. Phenylbutazone was more rapidly absorbed from the new formulation and higher plasma concentrations were achieved at shorter intervals after dosing. Drug elimination rate was unaffected by reformulation and despite faster absorption the total amounts of drug reaching the circulation from the new and commercial products were similar. It was concluded that replacing Butacote by the new formulation would provide the same therapeutic benefit.

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Plasma profiles following single, oral, and rectal doses of phenylbutazone in healthy volunteers

John¹,

Monk²,

Hubbard³

et al. 1983

Biopharm & Drug Disp

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Pharmacokinetics of phenylbutazone in healthy subjects after oral administration of single and multiple doses

Cited by 10 publications

References 9 publications

“Ain’t She a Bute?”: The Importance of Proper History Taking in a Case of Inappropriate Use of Horse NSAID in a Human

“Ain’t She a Bute?”: The Importance of Proper History Taking in a Case of Inappropriate Use of Horse NSAID in a Human

Bioavailability of phenylbutazone from a new enteric‐coated formulation with superior dissolution characteristics

Plasma profiles following single, oral, and rectal doses of phenylbutazone in healthy volunteers

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