Pharmacokinetics of rokitamycin after single administration to healthy volunteers

Abstract

The pharmacokinetics of rokitamycin tablets were studied in 12 healthy volunteers in a randomized cross-over design. The doses tested were 200 mg, 300 mg, 400 mg and 600 mg, as single oral administration. Rokitamycin was absorbed quickly with Tmax for all doses around 30 min after drug intake. Total AUC and Cmax values were linearly related to the administered dose. The buffer formulation determined a low interindividual variation. The overall findings show a good similarity with the data obtained in Japanese subjects. Tolerability was very good.

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

“…In clinical cases, rokitamycin has been well tolerated by patients who had reactions to macrolides belonging to the 16-membered ring macrolides [32]. In particular, tolerability to rokitamycin is very good and it has excellent or good responses without any side effects [33,34]. Further studies are needed to investigate the mechanisms of action of the drug and whether rokitamycin exhibits additive, synergistic or antagonistic effects in combination with other drugs in murine experiments.…”