Pharmacokinetics of seven major active components of Mahuang decoction in rat blood and brain by LC–MS/MS coupled to microdialysis sampling

Wan, Haoyu; Pan, Lujia; Wang, Yu; Li, Chang; Yu, Li; Zhou, Huifen; Wan, Haitong

doi:10.1007/s00210-019-01786-0

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…Therefore, a comparison with previous reports relevant to this study was necessary. The mean T max and t 1/2 of ephedrine reported in previous studies were 0.29-3.08 and 1.00-9.76 h, respectively [21][22][23][24][25]. The T max and t 1/2 of ephedrine obtained after the oral administration of SCRT were 0.85 ± 0.22 and 1.62 ± 0.74 h, respectively, within the range of the previously reported values.…”

Section: Pharmacokinetic Studysupporting

confidence: 86%

“…The T max and t 1/2 of paeoniflorin obtained after the oral administration of SCRT were 1.40 ± 0.55 and 1.27 ± 0.55 h, respectively, within the range of the previously reported values. The mean T max and t 1/2 of cinnamic acid reported in previous studies were 0.08-1.48 and 0.33-4.14 h, respectively [21,[38][39][40][41][42][43][44]. The T max of cinnamic acid obtained after the oral administration of SCRT was 0.35 ± 0.14 h, within the range of the previously reported values.…”

Section: Pharmacokinetic Studysupporting

confidence: 85%

See 1 more Smart Citation

Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines

et al. 2021

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The purpose of this study was to investigate the pharmacokinetic properties of ephedrine, paeoniflorin, and cinnamic acid after single or multiple doses of Socheongryong-tang (SCRT) were administered to rats, and to present an example of the pharmacokinetic changes following multiple doses of an herbal medicine. SCRT is a traditional herbal medicine that has been used clinically for a long time, and its main ingredients include ephedrine, paeoniflorin, and cinnamic acid. However, studies on the pharmacokinetic properties of SCRT are insufficient, and particularly, no pharmacokinetic information has been reported for multiple doses. In this study, SCRT was administered orally to rats once or multiple times, and plasma sampled at different times was quantitatively analyzed for ephedrine, paeoniflorin, and cinnamic acid using ultra-high-performance liquid chromatography-tandem mass spectrometry. There was a difference between the pharmacokinetic parameter values of each component (especially in paeoniflorin and cinnamic acid) obtained after single or multiple doses of SCRT. The actual observed values of each component obtained after multiple doses of SCRT were clearly different from the predicted results of multiple-dose simulations based on the pharmacokinetic profiles obtained after a single dose. The results confirmed that the plasma concentrations and, thus, exposures to paeoniflorin and cinnamic acid were significantly increased when SCRT was administered multiple times, whereas that of ephedrine was not. The results of this study are expected to provide useful pharmacokinetic data for the safety and efficacy evaluation of SCRT in the future and demonstrate the necessity of pharmacokinetic comparison studies according to single or multiple oral administrations of herbal medicines.

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Section: Pharmacokinetic Studysupporting

confidence: 86%

Section: Pharmacokinetic Studysupporting

confidence: 85%

Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines

et al. 2021

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“…EH and GR comprise a commonly used pair‐herb, which is widely used in the treatment of respiratory diseases, such as Mahuang decoction and Maxing–Shigan decoction. Based on our results and other articles, the pharmacokinetic parameters, such as T max , of ephedrine, pseudoephedrine and methylephedrine were quite different in YZS, Mahuang decoction (Wan et al, 2020) and Maxing–Shigan decoction (Li et al, 2015), which indicated that the different herbs combined with the EH–GR pair would influence the pharmacokinetic characteristics of these compounds. Similarly, differences in the pharmacokinetic profiles of glycyrrhizic acid and glycyrrhetinic acid could also be found in different prescriptions containing an EH–GR pair.…”

Section: Resultssupporting

confidence: 66%

Quantification of 10 bioactive components of Yazhangsan in rat plasma by LC–MS/MS and its application

Zhang

Chen

Liu

et al. 2020

Biomedical Chromatography

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Yazhangsan (YZS) is a common prescription for the treatment of cough and asthma caused by wind‐cold. The purpose of this study was to investigate the pharmacokinetic profiles of 10 bioactive components in YZS. A simple, sensitive and reliable high‐performance liquid chromatography coupled with a triple‐quadruple mass spectrometry method (LC–MS/MS) was developed and fully validated in this study for the measurement of these 10 bioactive compounds in rat plasma. One‐step protein precipitation method using methanol was applied to the treatment of rat plasma samples. Chromatographic separation was conducted on a C18 column by gradient elution, and water (containing 0.1% formic acid) and acetonitrile were chosen as the mobile phase. The analytes were quantified by using a mass spectrometer in multiple reaction monitoring scanning mode, and electrospray ionization was performed in positive and negative ion modes. The established method met the requirements for the quantification of these 10 bioactive compounds in biological samples, and it was successfully applied to the pharmacokinetic study of 10 components in rats after the intragastrical administration of YZS. This study will lay a foundation for the investigation of the mechanism of action of YZS and provide useful data for the rational use of YZS in clinical.

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“…(ii) For in vivo single drug studies, microdialysis being applied for PK monitoring and quantification of drugs in skin tissue ( Voelkner et al 2018 ) and plasma ( Girondi et al, 2018 , Wang et al, 2020c ), among others. (iii) For complex component systems, investigators established the study of Ermiao wan metabolites in bile ( Zhao et al, 2020 ) and Mahuang decoction in blood and brain ( Wan et al, 2020 ). (iv) It was used for the evaluation of PK parameters of drugs, especially combining PD and PK ( Wang et al, 2019 , Guo et al, 2019 ).…”

Section: Frontier Approaches and Technologies For Pharmacodynamic Sub...mentioning

confidence: 99%

Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances

Lin

Wang

et al. 2022

Arabian Journal of Chemistry

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Pharmacokinetics of seven major active components of Mahuang decoction in rat blood and brain by LC–MS/MS coupled to microdialysis sampling

Cited by 10 publications

References 19 publications

Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines

Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines

Quantification of 10 bioactive components of Yazhangsan in rat plasma by LC–MS/MS and its application

Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances

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