Pharmacokinetics of tobramycin in ducks and sex-related differences

Dimitrova, D.; Moutafchieva, R.; Kanelov, I.; Dinev, Toncho; Lashev, L.

doi:10.1016/j.tvjl.2007.10.003

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…143 Gender Differences in the PK of antibacterial drugs (including the sulphonamides) have been shown when comparing hens and cockerels. 144 Tobramycin was eliminated more rapidly in ducks than in drakes, 145 similar to observations with apramycin. 144 Disease Generally, antimicrobial agents are administered to birds that are affected by infection, from early subtle clinical stages to more obvious florid disease.…”

Section: Fatty Liversupporting

confidence: 55%

Antimicrobial prescribing guidelines for poultry

Gray¹,

Jenner²,

Norris³

et al. 2021

Aust Veterinary J

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Forewordantimicrobial prescribing guidelines for poultry Antimicrobials are essential to modern medicine for treating a range of infections in humans and animals. Importantly, antimicrobial resistance (AMR) is a growing global threat that presents a serious risk to human and animal health. Inappropriate and/or unrestrained use of antimicrobials in humans and animals exerts a strong selection pressure on microbial populations to evolve resistant traits. As a result, antimicrobials have become less effective over time leading to treatment complications and failures, and increased healthcare costs for people and animals. Resistant organisms spread between people, animals and the environment. Globalisation and international travel facilitates this spread between countries.Here in Australia, the veterinary profession and food-producing animal industries have a long history of addressing AMR. Their previous and ongoing worka result of partnerships across the animal sectorhas resulted in demonstrated low levels of AMR in our food-producing animals. Over the past 5 years, the veterinary profession has consolidated its partnership with industry and government by helping to successfully implement Australia's First National Antimicrobial Resistance Strategy 2015-19. With the recent release of Australia's National Antimicrobial Resistance Strategy -2020 and Beyond (2020 AMR Strategy), the veterinary profession will continue to play a critical role in how we minimise AMR.One of the seven key objectives of the 2020 AMR Strategy relates to appropriate antimicrobial usage and antimicrobial stewardship practices. Resistance to antimicrobials occurs naturally in microorganisms, but it is significantly amplified by antimicrobial overuse, growth promotion use, and poor husbandry and management.The antimicrobial prescribing guidelines for poultry directly addresses the fourth objective of the 2020 AMR Strategy, and in particular, Priority Area for Action 4.1, that seeks to 'ensure that coordinated, evidence-based antimicrobial prescribing guidelines and best-practice supports are developed and made easily available, and encourage their use by prescribers'. These guidelines for Australian poultry veterinarians are sure to be a ready resource. They have been developed specifically for the Australian poultry industry and contain best-practice prescribing information to help clinical veterinarians in their day-to-day use of antimicrobials. The guidelines encourage veterinarians to first pause and consider the need to use antimicrobials in that circumstance: Are there effective non-antimicrobial alternatives? Prevention and control of infections through strict on-farm biosecurity is a recognised approach to minimising disease entry and the need to use antimicrobials. Vaccination may also be available to control several important poultry diseases. If antimicrobial use is indicated, have you considered the five rights: right drug, right time, right dose, right duration and right route? Using a lower rating or narrow-spectrum antimicrobial i...

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Section: Fatty Liversupporting

confidence: 55%

Antimicrobial prescribing guidelines for poultry

Gray¹,

Jenner²,

Norris³

et al. 2021

Aust Veterinary J

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“…Although reports on the pharmacokinetics of treatments against parasites in wild animals of different sexes are scarce, the literature reports sex effects on drug kinetics (e.g. Klein 2004;Dimitrova et al 2009), including studies with antimalarial drugs (Gordi et al 2002). Different factors tightly related to sex, such as hormone concentrations and genetic characteristics, may affect the absorption and metabolism of drugs (Lashev et al 1995;Pinsonneault & Sadée 2004).…”

Section: Discussionmentioning

confidence: 99%

The blood parasiteHaemoproteusreduces survival in a wild bird: a medication experiment

Puente¹,

Merino²,

Tomás

et al. 2010

Biol. Lett.

168

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While avian chronic haemoparasite infections induce reproductive costs, infection has not previously been shown to affect survival. Here, we experimentally reduced, through medication, the intensity of infection by Haemoproteus parasites in wild-breeding female blue tits Cyanistes caeruleus. However, this treatment did not reduce the intensity of infection in males or the intensity of infection by Leucocytozoon. Medicated females, but not males, showed increased local survival until the next breeding season compared with control birds. To our knowledge, this is the first empirical evidence showing long-term direct survival costs of chronic Haemoproteus infections in wild birds.

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“…Additionally, only mares were used in the present study. Although it is not possible to determine whether this affected the results of this study, differences in the pharmacokinetics of tobramycin based on gender have been reported in humans and ducks (Falcão et al ., ; Inclan et al ., ; Dimitrova et al ., ). However, in humans, these differences are thought to be clinically insignificant (Inclan et al ., ), and in ducks, the differences were only present following IV, and not IM, administration (Dimitrova et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of tobramycin following intravenous, intramuscular, and intra‐articular administration in healthy horses

Newman

Prange

Jennings

et al. 2013

Vet Pharm & Therapeutics

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The objectives of this study were to examine the pharmacokinetics of tobramycin in the horse following intravenous (IV), intramuscular (IM), and intra-articular (IA) administration. Six mares received 4 mg/kg tobramycin IV, IM, and IV with concurrent IA administration (IV+IA) in a randomized 3-way crossover design. A washout period of at least 7 days was allotted between experiments. After IV administration, the volume of distribution, clearance, and half-life were 0.18 ± 0.04 L/kg, 1.18 ± 0.32 mL·kg/min, and 4.61 ± 1.10 h, respectively. Concurrent IA administration could not be demonstrated to influence IV pharmacokinetics. The mean maximum plasma concentration (Cmax ) after IM administration was 18.24 ± 9.23 μg/mL at 1.0 h (range 1.0-2.0 h), with a mean bioavailability of 81.22 ± 44.05%. Intramuscular administration was well tolerated, despite the high volume of drug administered (50 mL per 500 kg horse). Trough concentrations at 24 h were below 2 μg/mL in all horses after all routes of administration. Specifically, trough concentrations at 24 h were 0.04 ± 0.01 μg/mL for the IV route, 0.04 ± 0.02 μg/mL for the IV/IA route, and 0.02 ± 0.02 for the IM route. An additional six mares received IA administration of 240 mg tobramycin. Synovial fluid concentrations were 3056.47 ± 1310.89 μg/mL at 30 min after administration, and they persisted for up to 48 h with concentrations of 14.80 ± 7.47 μg/mL. Tobramycin IA resulted in a mild chemical synovitis as evidenced by an increase in synovial fluid cell count and total protein, but appeared to be safe for administration. Monte Carlo simulations suggest that tobramycin would be effective against bacteria with a minimum inhibitory concentration (MIC) of 2 μg/mL for IV administration and 1 μg/mL for IM administration based on Cmax :MIC of 10.

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Pharmacokinetics of tobramycin in ducks and sex-related differences

Cited by 11 publications

References 4 publications

Antimicrobial prescribing guidelines for poultry

Antimicrobial prescribing guidelines for poultry

The blood parasiteHaemoproteusreduces survival in a wild bird: a medication experiment

Pharmacokinetics of tobramycin following intravenous, intramuscular, and intra‐articular administration in healthy horses

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