Pharmacokinetics of tolfenamic acid after different administration routes in geese (<i>Anser cygnoides</i>)

Türk, Erdinç; Tekeli, İbrahim Ozan; Çorum, Duygu Durna; Çorum, Orhan; Sakin, Fatih; Üney, Kamil

doi:10.1111/jvp.12956

Cited by 18 publications

(22 citation statements)

References 43 publications

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Section: Discussionsupporting

confidence: 73%

“…After oral administration of CRP at a dose of 10 mg/kg in quails, the C max (6.53 μg/mL), and T max (0.92 h) were higher and shorter, respectively, than those previously reported in vultures at a dose of 11.5 mg/kg (C max : 1.05 μg/mL, T max : 4.04 h (Fourie et al, 2015). TA following IM and oral administration at a dose of 2 mg/kg exhibited higher C max in quails (IM; 13.49 μg/mL, oral; 5.27 μg/mL) than that reported in geese (IM; 4.89 μg/mL, oral; 2.92 μg/mL, Turk et al, 2021). However, T max of TA in quails (IM; 0.29 h, oral; 0.83 h) was similar to that reported in geese (IM; 0.25 h, oral; 1.0 h, Turk et al, 2021).…”

Section: Discussionmentioning

confidence: 72%

“…4.89 μg/mL, oral; 2.92 μg/mL, Turk et al, 2021). However, T max of TA in quails (IM; 0.29 h, oral; 0.83 h) was similar to that reported in geese (IM; 0.25 h, oral; 1.0 h, Turk et al, 2021). The variable C max of MLX, CRP, and TA in bird species may be due to differences in nutritional habits, metabolism, and drug formulations as well as anatomical and physiological differences.…”

Section: Discussionmentioning

confidence: 99%

“…TA is a NSAID belonging to the fenamate group and has been suggested for use in painful and inflammatory conditions in livestock and pet animals (CVMP, 1997; Lascelles et al, 2007). TA after extravascular administration in geese is well tolerated and has exhibited good bioavailability and longer elimination half‐life according to intravenous administration (Turk et al, 2021). It has reportedly been used safely in vultures (Galligan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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The aim of this study was to determine the pharmacokinetics of meloxicam (MLX), carprofen (CRP), and tolfenamic acid (TA) in Japanese quails (Coturnix coturnix japonica) following intramuscular (IM) and oral administration at doses of 1, 10, and 2 mg/kg, respectively. A total of 72 quails were randomly divided into 3 equal groups as MLX, CRP, and TA. Each group was separated into two sub‐groups that received IM and oral administration of each drug. Plasma concentrations of MLX, CRP, and TA were determined using HPLC‐UV and analyzed by non‐compartmental method. The t1/2ʎz and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The Vdarea/F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA after IM administration was 0.12, 0.19, and 0.09 L/h/kg. MLX, CRP, and TA after oral administration showed significantly lower Cmax and longer Tmax compared with IM administration. The relative bioavailability of MLX, CRP, and TA following oral administration in quails was 76.13%, 61.46%, and 57.32%, respectively. The IM and oral route of MLX, CRP, and TA can be used for the treatment of various conditions in quails. However, further research is necessary to determine the pharmacodynamics and safety of MLX, CRP, and TA before use in quails.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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“…The binding of drugs to plasma proteins and body composition affect the distribution volume [ 45 ]. Because NSAIDs are highly bound to plasma proteins, their V dss is generally low [ 46 ]. The binding ratio of carprofen to plasma proteins is not known in fish, but it is highly protein-bound (>99%) in mammals [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

et al. 2021

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The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t1/2λz) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (Cmax) was 3.96 and 2.52 μg/mL with the time to reach Cmax of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t1/2λz for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock.

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Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

Corum,

Durna Corum,

Marin

et al. 2024

Veterinary Medicine & Sci

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BackgroundAlthough research on the mechanism and control of pain and inflammation in fish has increased in recent years, the use of analgesic drugs is limited due to the lack of pharmacological information about analgesic drugs. Tolfenamic acid is a non‐steroidal anti‐inflammatory drug and can be used in fish due to its low side effect profile and superior pharmacokinetic properties.ObjectivesThe pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid were investigated following single intravascular (IV), intramuscular (IM) and oral administration of 2 mg/kg in rainbow trout at 13 ± 0.5°C.MethodsThe experiment was carried out on a total of 234 rainbow trout (Oncorhynchus mykiss). Tolfenamic acid was administered to fish via IV, IM and oral route at a dose of 2 mg/kg. Blood samples were taken at 13 different sampling times until the 72 h after drug administration. The plasma concentrations of tolfenamic acid were quantified using high pressure liquid chromatography–ultraviolet (UV) and pharmacokinetic parameters were assessed using non‐compartmental analysis.ResultsThe elimination half‐life (t1/2ʎz) of tolfenamic acid for IV, IM and oral routes was 3.47, 6.75 and 9.19 h, respectively. For the IV route, the volume of distribution at a steady state and total body clearance of tolfenamic acid were 0.09 L/kg and 0.03 L/h/kg, respectively. The peak plasma concentration and bioavailability for IM and oral administration were 8.82 and 1.24 µg/mL, and 78.45% and 21.48%, respectively. The mean plasma protein binding ratio of tolfenamic acid in rainbow trout was 99.48% and was not concentration dependent.ConclusionsWhile IM route, which exhibits both the high plasma concentration and bioavailability, can be used in rainbow trout, oral route is not recommended due to low plasma concentration and bioavailability. However, there is a need to demonstrate the pharmacodynamic activity of tolfenamic acid in rainbow trout.

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Pharmacokinetics of tolfenamic acid after different administration routes in geese (Anser cygnoides)

Cited by 18 publications

References 43 publications

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

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