Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Huang, Xi

doi:10.3748/wjg.v6.i3.384

Cited by 26 publications

(16 citation statements)

References 9 publications

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“…However, no studies are available on the pharmacokinetics of such decoctions in acute pancreatitis. According to the theory "syndrome and treatment pharmacokinetics", YMFSS should influence the pharmacokinetics of DCQD [9] , but it has not been proved experimentally up to date.…”

Section: Introductionmentioning

confidence: 99%

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

Gong¹,

Tang²,

Yu³

et al. 2009

WJG

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AIM:To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The Cmax (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T1/2α of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and Tmax of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group. CONCLUSION:

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Section: Introductionmentioning

confidence: 99%

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

Gong¹,

Tang²,

Yu³

et al. 2009

WJG

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“…The former decoction contains 5 herbs, and the latter has 7 herbs (Wu and Li, 2009;Zhang, 2010). Herb-herb interactions often occur (Huang et al, 2000). In addition, recent reviews have indicated that disease states can modify the pharmacokinetics of drugs (Ventresca and Mariani, 1996).…”

Section: Discussionmentioning

confidence: 97%

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Qiu

Huang

Chen

et al. 2011

Journal of Ethnopharmacology

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“…Therefore, the pharmacokinetic parameters vary greatly due to the difference in the mode of administration of medication and the prescription compatibility principal (Huang et al, 2000). Therefore, for prescription compatibility involving dahuang and mangxiao, the time and time intervals at which XCQD and DCQD are orally administered should be based on the pharmacokinetic parameters in the current study.…”

Section: Pharmacokinetic Studymentioning

confidence: 99%

Determination and pharmacokinetic comparison of rhein in rats after oral dosed with Da‐Cheng‐Qi decoction and Xiao‐Cheng‐Qi decoction

Tang

Huang

et al. 2007

Biomedical Chromatography

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Da-Cheng-Qi decoction (DCQD) is composed of dahuang, houpu, zhishi and mangxiao, while Xiao-Cheng-Qi decoction (XCQD) just contains dahuang, houpu, and zhishi. A validated high-performance liquid chromatographic (HPLC) method was developed for the determination and pharmacokinetic comparison of rhein in rats. It was performed on a reversed-phase C(18) column (150 x 4.6 mm) with a mobile phase of methanol and 0.2% acetic acid (89:11, v/v) and ultraviolet detection at 254 nm. The assay was linear over the range 30-3000 ng/mL (r(2) = 0.9991), with mean percentage recovery of 101.4%. The RSD of intra- and inter-day precision were less than 3.0%, with accuracy in the range 96.8-102.5% for each of the concentrations tested. Following oral administration, rhein plasma levels revealed curves characterized by peaks at 20.5 and 30.1 min corresponding to dosages of 15 mg/kg (XCQD) and 20 mg/kg (DCQD) at mean concentrations of 1184.67 and 1814.27 ng/mL, respectively. The half-lives of rhein from XCQD and DCQD were 45.3 and 139.6 min, respectively. AUC(0-12h) of rhein after oral dosage with XCQD and DCQD were 3435.68 and 5382.25 microg/L h, respectively. The pharmacokinetic parameters may be used to guide the clinical prescription compatibility of traditional Chinese prescriptions related to dahuang and mangxiao.

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Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Cited by 26 publications

References 9 publications

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Determination and pharmacokinetic comparison of rhein in rats after oral dosed with Da‐Cheng‐Qi decoction and Xiao‐Cheng‐Qi decoction

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