Pharmacokinetics of triamcinolone acetonide following intramuscular and intra‐articular administration to exercised<scp>T</scp>horoughbred horses

Knych, Heather K.; Vidal, Martin A.; Casbeer, H. C.; McKemie, Daniel S.

doi:10.1111/evj.12059

Cited by 30 publications

(41 citation statements)

References 8 publications

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“…Similar to what has been reported for other intra-articular corticosteroids in horses, [7,8,12] plasma betamethasone concentrations are not reflective of concentrations in the joint and therefore are likely not a good indicator of the duration of effect of intra-articular corticosteroids. In the current study, concentrations of betamethasone in plasma fell below detectable levels at 72 h post administration in 10/12 horses, at which time concentrations in the treated joint (right radiocarpal joint) were still well above the LOD of the assay (9.83 ± 10.1 ng/mL).…”

Section: Discussionsupporting

confidence: 59%

Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra‐articular administration to exercised thoroughbred horses

Knych

Stanley

Harrison

et al. 2017

Drug Testing and Analysis

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aThe use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racing-fit adult Thoroughbred horses received a single intra-articular administration (9 mg) of a betamethasone sodium phosphate and betamethasone acetate injectable suspension into the right antebrachiocarpal joint. Blood, urine, and synovial fluid samples were collected prior to and at various times up to 21 days post drug administration. All samples were analyzed using tandem liquid chromatography-mass spectrometry. Plasma data were analyzed using compartmental pharmacokinetic modeling. Maximum measured plasma betamethasone concentrations were 3.97 ± 0.23 ng/mL at 1.45 ± 0.20 h. The plasma elimination half-life was 7.48 ± 0.39 h. Betamethasone concentrations were below the limit of detection in all horses by 96 h and 7 days in plasma and urine, respectively. Betamethasone fell below the limit of detection in the right antebrachiocarpal joint between 14 and 21 days. Results of this study provide information that can be used to regulate the use of intra-articular betamethasone in the horse.

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Section: Discussionsupporting

confidence: 59%

Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra‐articular administration to exercised thoroughbred horses

Knych

Stanley

Harrison

et al. 2017

Drug Testing and Analysis

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“…This parallels TA concentrations in serum, with peak values being of a greater magnitude with IA administration compared to the IM group. These results are in agreement with previous pharmacokinetic studies reporting that after an IA administration, TA reaches higher serum concentration, but for a shorter duration, than after an IM administration .…”

Section: Discussionsupporting

confidence: 93%

Intra‐articular triamcinolone acetonide improves lung function in horses with severe asthma

Bessonnat

Picotte

Lavoie

2019

Equine Veterinary Journal

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Summary Background Locally administered corticosteroids are commonly used to treat joint diseases in sport and racehorses. As they are also the most potent drugs for the treatment of equine asthma, we hypothesised that the intra‐articular corticosteroids used to treat joint diseases also improve the lung function in horses with severe asthma, thus potentially delaying the diagnosis of this common lung condition. Objectives To compare the effects of intra‐articular (IA) and intramuscular (IM) triamcinolone acetonide (TA) on lung function in horses with severe asthma. Study design Randomised and controlled experiment on asthma‐prone research animals. Methods Horses with severe asthma in clinical exacerbation were given either 20 mg of TA in both tarsocrural joints (n = 5; 40 mg/horse) or 40 mg of TA intramuscularly (n = 5). Lung function and TA serum concentrations were measured weekly for 35 days. TA serum concentrations were also evaluated on day 3. Results The pulmonary resistance (RL) and elastance (EL) values decreased by day 7 in the IA group (P<0.0001 and P = 0.003, respectively) and by day 14 in the IM group (P = 0.002 and 0.03, respectively). Lung function was improved up to days 21 and 28 in the IA and IM groups, respectively, when compared with baseline. TA serum levels were below the quantification limit (100 pg/ml) for 4 and 3 of the 5 horses in the IA and IM groups, respectively, on day 7. The area under the curve for RL, EL and the serum concentrations of TA were similar in both groups. Main limitations The response of horses with severe asthma might differ from that of high‐performance horses with mild/moderate asthma. Conclusions Intra‐articular administration of TA improves lung function in horses with severe asthma, an effect that persists when TA serum concentration is below the quantification level that is employed as a threshold by the International Association of Racing Commissioners.

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“…) describing the administration of 9 mg (Knych et al . ) or 20–30 mg (Soma et al . ) of TCA into a single antebrachiocarpal joint.…”

Section: Discussionmentioning

confidence: 99%

“…All samples were stored at −20°C (approximately 2 weeks) until analysed by tandem liquid chromatography mass spectrometry (LC‐MS/MS) for quantitation of serum methylprednisolone (MP), TCA, isoflupredone (IP) and betamethasone concentrations using previously validated assays used for post race drug testing (Knych et al . , 2014, ).…”

Section: Methodsmentioning

confidence: 99%

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Clearance of corticosteroids following intra‐articular administration of clinical doses to racehorses

Knych

Blea²,

Arthur

et al. 2016

Equine Veterinary Education

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Over the last few years there has been a nationwide cooperative effort to establish threshold concentrations and withdrawal time guidelines for corticosteroid use in racehorses. As dosing regimens are specific to individual horses and highly variable, it is not possible to establish regulatory guidelines for every dosing scenario and therefore they are often based on single dose administration studies. The goal of the study described here was to assess the applicability of current regulatory recommendations for intraarticular corticosteroids based on clinical protocols used by practitioners. A total of 58 Thoroughbred and 82 Quarter Horse racehorses received varying doses of triamcinolone acetonide, methylprednisolone acetate, isoflupredone or betamethasone intra-articularly in various joints by the treating practitioner. Blood samples were collected at 0, 7, 10, 14, 21, 28 and 35 days post drug administration and serum samples analysed by liquid chromatography mass spectrometry for quantitation of drug concentrations. Serum elimination varied depending upon the dose and the number and specific joints treated. Serum concentrations fell below the ARCI threshold guidance by Day 7 (100 pg/ml) for both triamcinolone acetonide (2-40 mg dose) and isoflupredone acetate (4-30 mg dose) and Day 21 (100 pg/ml) for methylprednisolone acetate (20-600 mg dose). Betamethasone fell below the regulatory threshold (10 pg/ml) by 7 days for all Quarter Horses and for 7/10 Thoroughbreds studied. Drug concentrations were below the regulatory threshold by Day 10 in the remaining 3 horses receiving betamethasone.

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Pharmacokinetics of triamcinolone acetonide following intramuscular and intra‐articular administration to exercisedThoroughbred horses

Cited by 30 publications

References 8 publications

Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra‐articular administration to exercised thoroughbred horses

Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra‐articular administration to exercised thoroughbred horses

Intra‐articular triamcinolone acetonide improves lung function in horses with severe asthma

Clearance of corticosteroids following intra‐articular administration of clinical doses to racehorses

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