Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses

Colitz, Carmen M. H.; Latimer, Federico G.; Cheng, Hao; Chan, K; Reed, Stephen M.; Pennick, Genneth J.

doi:10.2460/ajvr.68.10.1115

Cited by 38 publications

(42 citation statements)

References 27 publications

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“…Voriconazole is detectable in human medullary and cortical bone, with especially high concentrations (approximately 5 times the plasma concentration) in the former (208). The concentration of voriconazole in synovial fluid from a single patient was approximately one-third the plasma concentration (208), while in horses, the mean voriconazole synovial fluid/plasma concentration ratio was 0.6 (209).…”

Section: Bonementioning

confidence: 99%

Tissue Penetration of Antifungal Agents

Troke²,

2014

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SUMMARY Understanding the tissue penetration of systemically administered antifungal agents is critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the time course of an antifungal drug and its absolute concentrations within tissues may differ significantly from those observed in the bloodstream. In addition, tissue concentrations must also be interpreted within the context of the pathogenesis of the various invasive fungal infections, which differ significantly. There are major technical obstacles to the estimation of concentrations of antifungal agents in various tissue subcompartments, yet these agents, even those within the same class, may exhibit markedly different tissue distributions. This review explores these issues and provides a summary of tissue concentrations of 11 currently licensed systemic antifungal agents. It also explores the therapeutic implications of their distribution at various sites of infection.

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Section: Bonementioning

confidence: 99%

Tissue Penetration of Antifungal Agents

Troke²,

2014

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“…, 2006). The disposition over time after repeated dosing and concentrations of voriconazole in plasma, preocular tear film, synovial and cerebrospinal fluids have been investigated in horses (Colitz et al. , 2007).…”

Section: Introductionmentioning

confidence: 99%

Distribution of voriconazole in seven body fluids of adult horses after repeated oral dosing

Passler

Chan

Stewart

et al. 2010

Journal of Veterinary Pharmacology and Therapeutics

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The purpose of this study was to assess safety and alterations in body fluid concentrations of voriconazole in normal horses on days 7 and 14 following once daily dose of 4 mg/kg of voriconazole orally for 14 days. Body fluid drug concentrations were determined by the use of high performance liquid chromatography (HPLC). On day 7, mean voriconazole concentrations of plasma, peritoneal, synovial and cerebrospinal fluids, aqueous humor, epithelial lining fluid (ELF), and urine were 1.47 +/- 0.63, 0.61 +/- 0.22, 0.70 +/- 0.20, 0.62 +/- 0.26, 0.55 +/- 0.32, 79.45 +/- 69.4, and 1.83 +/- 0.44 microg/mL respectively. Mean voriconazole concentrations in the plasma, peritoneal, synovial and cerebrospinal fluids, aqueous humor, ELF and urine on day 14 were 1.60 +/- 0.37, 1.02 +/- 0.27, 0.86 +/- 0.25, 0.64 +/- 0.21, 0.68 +/- 0.13, 47.76 +/- 45.4 and 3.34 +/- 2.17 respectively. Voriconazole concentrations in the bronchoalveolar cell pellet were below the limit of detection. There was no statistically significant difference between voriconazole concentrations of body fluids when comparing days 7 and 14. Results indicated that voriconazole distributes widely into body fluids.

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“…In contrast, none of our patients presented with cerebral mycosis. Studies of chickens and horses revealed remarkable interspecies differences in tissue penetration of VRC (2,4,20). In rats, free extracellular lung concentrations reached ϳ2.5 g/ml after a single dose (13).…”

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confidence: 99%

Human Tissue Distribution of Voriconazole

Weiler

Fiegl

MacFarland

et al. 2011

Antimicrob Agents Chemother

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Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the brain, 6.89 μg/g (IQR, 24.16 μg/g) in the liver, 6.47 μg/g (IQR, 6.19 μg/g) in the kidneys, 5.60 μg/g (IQR, 11.49 μg/g) in the spleen, and 7.55 μg/g (IQR, 16.91 μg/g) in the myocardium.

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Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses

Cited by 38 publications

References 27 publications

Tissue Penetration of Antifungal Agents

Tissue Penetration of Antifungal Agents

Distribution of voriconazole in seven body fluids of adult horses after repeated oral dosing

Human Tissue Distribution of Voriconazole

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