Pharmacokinetics of β-Methyldigoxin in Healthy Humans II: Oral Studies and Bioavailability

Pharmacokinetic Study of .BETA.-Methyldigoxin by Enzyme Immunoassay Using a Novel Specific Antiserum in Rats.

“…Hinderling et al have reported that Dx3 produced in the body after MDx3 administration could be detected at a ratio of about 10% to the dosage. 5,6) Our results and their reports indicate that Dx3 metabolized after MDx3 administration should bring about measurement errors at low level. Therefore, it is estimated that serum levels monitored by EIA-II after MDx3 administration provide MDx3 concentration containing Dx3.…”

Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and β-methyldigoxin in rats

“…In contrast, biliary excretion of β‐methyldigoxin remained unchanged by the coadministration of cyclosporin A (Figure 4). β‐Methyldigoxin is known to be demethylated to digoxin to some extent mainly in the liver after oral administration 42,43. In the present study, we determined the concentrations of digoxin and β‐methyldigoxin in plasma separately after intravenous administration of β‐methyldigoxin, and the percentage of digoxin was approximately 20% of total plasma concentration of digitalis compounds at 30 min and 30% at 120 min after administration.…”