Pharmacokinetics, Pharmacodynamics and Local Tolerance at Injection Site of Marbofloxacin Administered by Regional Intravenous Limb Perfusion in Standing Horses

Abstract

These data suggest that RIVLP of marbofloxacin (0.67 mg/kg) could be a safe and effective method for treatment of infections of the distal portion of the limb for susceptible organisms.

Regional limb perfusion in horses

“…Pharmacodynamic studies have shown that all three indices, T>MIC (time the concentration remains above the MIC), C max and area under the curve, are important in evaluating antimicrobial efficacy, and even β-lactams efficacy can gain from higher C max (Gunderson and others 2001). RLP PK studies in horses support the use of ceftiofur, vancomycin, erythromycin, enrofloxacin, marbofloxacin and chloramphenicol (Pille and others 2005, Rubio-Martínez and others 2005, Parra-Sanchez and others 2006, Kelmer and others 2013b, 2015, Lallemand and others 2013). Meticillin-resistant Staphylococcus aureus (MRSA) infections are becoming more common in equine medicine and due to their MDR nature they pose a therapeutic challenge (Weese and others 2005).…”

Meropenem synovial fluid concentrations after intravenous regional limb perfusion in standing horses

“…IVRLP achieves high concentration and pressure gradients by use of a tourniquet and increased vascular volume . The pharmacokinetic parameters of IVRLP have been investigated in the horse for amikacin, gentamicin, chloramphenicol, erythromycin, enrofloxacin, imipenem, vancomycin, marbofloxacin, and ceftiofur . IVRLP produces high concentrations of antimicrobial in the synovial fluid and tissues of the entire isolated portion of the limb .…”

Pharmacokinetics of ceftazidime after regional limb perfusion in standing horses

“…18 The constant battle against resistant bacteria creates a growing need for the development of more efficient treatments. As a result, significant research effort has recently focused on RLP, such as investigating combinations of antimicrobials, 19,20 the use of additional types of antimicrobials, [21][22][23][24] and improving the technique. 9,11,25 Ceftazidime is a member of the third generation cephalosporin group of b-lactam antibiotics.…”