Pharmacokinetics, Safety, and Tolerability of Amygdalin and Paeoniflorin After Single and Multiple Intravenous Infusions of Huoxue-Tongluo Lyophilized Powder for Injection in Healthy Chinese Volunteers

Li, Xiaobing; Shi, Fuguo; Zhang, Run; Sun, Chenglong; Gong, Chuting; Jian, Lingyan; Ding, Li

doi:10.1016/j.clinthera.2015.12.005

Cited by 17 publications

(13 citation statements)

References 17 publications

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“…The clearance (CL) of paeoniflorin was 10.4 L/h, 11.3 L/h, and 11.2 L/h respectively; and the apparent distribution volume ranged from 16.8-18.1. Maximum plasma concentration (Cmax) reached 402.2-1081.0 ng/mL when the dose was increased from 18.3-54.1 mg/mL ( 27 ).…”

Section: Paeoniflorinmentioning

confidence: 99%

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Ilyas

et al. 2022

Front. Immunol.

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Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.

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Section: Paeoniflorinmentioning

confidence: 99%

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Ilyas

et al. 2022

Front. Immunol.

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“…11,23,24 PK parameters were also determined in Chinese human volunteers. 23 The mean half-life (t1/2) of PF for male and female subjects after a single IV injection of 18.3, 35.8, or 54.1 mg was 1.9, 1.9, or 1.8 hours, with a clearance (CL) of 10.4, 11.3, and 11.2 L/h, respectively. 23 The apparent volume of distribution (V ss ) ranged from 16.8 to 18.1 L.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases

Jiao

Varghese

Wang

et al. 2021

Journal of Cardiovascular Pharmacology

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:The monoterpene glycoside paeoniflorin (PF) is the principal active constituent of the traditional Chinese herbal medicines, Radix Paeoniae Alba and Radix Paeoniae Rubra, which have been used for millennia to treat cardiovascular diseases (eg, hypertension, bleeding, and atherosclerosis) and neurological ailments (eg, headaches, vertigo, dementia, and pain). Recent evidence has revealed that PF exerts inhibitory effects on inflammation, fibrosis, and apoptosis by targeting several intracellular signaling cascades. In this review, we address the current knowledge about the pharmacokinetic properties of PF and its molecular mechanisms of action. We also present results from recent preclinical studies supporting the utility of PF for the treatment of pain, cerebral ischemic injury, and neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Moreover, new evidence suggests a general protective role of PF in heart attack, diabetic kidney, and atherosclerosis. Mechanistically, PF exerts multiple anti-inflammatory actions by targeting toll-like receptor-mediated signaling in both parenchymal and immune cells (in particular, macrophages and dendritic cells). A better understanding of the molecular actions of PF may lead to the expansion of its therapeutic uses.

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“…In another study on healthy Chinese human subjects prepared by Li et al [14], the researchers used Huoxue-Tongluo lyophilized powder for injection (HTLPI) in which amygdalin is a bioactive component, since HTLPI is a mixture of Paeoniae Radix Rubra and Persicae semen. The study showed that sex did not affect the pharmacokinetic properties of amygdalin significantly.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Experimental and Therapeutic Trials of Amygdalin

Salama¹,

Ramadan²,

Alsanory³

et al. 2019

Int J Biochem Pharmacol

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Natural substances and alternative medications such as amygdalin gained huge popularity in treating various diseases due to wide availability and relatively low cost. Nevertheless, their use may cause serious side effects unless appropriate doses are considered. Therefore, this review illustrates the purported anticancer activity of amygdalin as well as its other effects on different body systems. For instance, the endocrine, urinary, genital and respiratory systems, considering its toxic side effects. Also, this review mentions a variety of clinical trials using amygdalin on both, humans and animals.

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Pharmacokinetics, Safety, and Tolerability of Amygdalin and Paeoniflorin After Single and Multiple Intravenous Infusions of Huoxue-Tongluo Lyophilized Powder for Injection in Healthy Chinese Volunteers

Cited by 17 publications

References 17 publications

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases

Experimental and Therapeutic Trials of Amygdalin

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