Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin and its metabolite ciprofloxacin, and sulfachloropyridazine‐trimethoprim in Taihe black‐boned silky fowls

Abstract

Enrofloxacin (ENR) and sulfachloropyridazine combined with trimethoprim (TMP) were commonly used in poultries to treat bacterial infections. In this study, the pharmacokinetics of these antibiotics in four tissues of Taihe black‐boned silky fowls was studied. The results showed that these drugs were absorbed and distributed rapidly, with the highest concentration showing in skin. Meanwhile, ENR and its metabolite ciprofloxacin (CIP) and TMP were depleted slowly, particularly in skin with the elimination half‐lives being 37.1, 36.9, and 72.7 days, respectively. It may be attributed to the abundance of melanin in skin. The dietary risk assessment suggested that the long‐term dietary intakes of ENR, CIP, and TMP showed a considerable threat to human health. Based on the experiment, the withdrawal times of 284 days for ENR + CIP and 159 days for TMP were acquired, which showed that these drugs are not appropriate for the application in Taihe black‐boned silky fowls.

Withdrawal time of danofloxacin and difloxacin and in vitro binding phenomenon to melanin in black‐boned silky fowl

“…When detecting the residues of veterinary drugs in commercially available chicken meat, we found fluoroquinolone residues in the tissues of bldack-boned silky fowl, but rarely in yellow chickens or white chickens. In addition, Yuan et al (2023) have been shown that enrofloxacin is not appropriate for application in black-boned silky fowl due to its long WT in black-boned silky fowl, and the 2020 Veterinary Pharmacopoeia has explicitly banned enrofloxacin in black-boned silky fowl, but the application of fluoroquinolones of similar structure has not been regulated for black-boned silky fowl.…”

“…In addition, Yuan et al. (2023) have been shown that enrofloxacin is not appropriate for application in black‐boned silky fowl due to its long WT in black‐boned silky fowl, and the 2020 Veterinary Pharmacopoeia has explicitly banned enrofloxacin in black‐boned silky fowl, but the application of fluoroquinolones of similar structure has not been regulated for black‐boned silky fowl.…”

Comparison of gamithromycin residue depletion in yellow-feather and white-feather broilers after one single subcutaneous injection

“…Research on the impact of feather color on drug disposition is currently limited. However, findings indicate that the elimination time of some drugs in silky chickens is significantly longer compared to other chicken breeds ( Liu et al, 2021 ; Chen et al, 2023 ; Hu et al, 2023 ; Yuan et al, 2023 ). The prevailing consensus suggests that silkie tissue exhibits a heightened affinity for drugs, primarily attributed to elevated melanin levels ( Chen et al, 2023 ).…”

Integrated transcriptome and proteome analysis reveals the unique molecular features and nutritional components on the muscles in Chinese Taihe black-bone silky fowl chicken

“…The Chinese Taihe silky fowl chicken is a national product of geographical indication that known for its top ten characteristics, high nutritional and medicinal value [ 28 , 29 ]. The chicken of Taihe Black-bone silky fowl is fresh and tender in meat with high protein and low fat, which the average crude protein content of 52.72% and crude fat only accounting for 24.17% [ 30 ].…”