Pharmacologic and Molecular Therapies of the Cochlear and Vestibular Labyrinth

Hearing results and quality of life after streptomycin/dexamethasone perfusion for meniere's disease

“…Streptomycin had become difficult to obtain, and there was a perception from earlier studies that it was associated with a high rate of hearing loss. Both drugs are certainly cochleotoxic at higher doses, but there is debate as to which is superior in terms of its ability to selectively ablate vestibular function with the least effect on cochlear function or even whether either drug is selectively vestibulotoxic at all 37, 38. Many recent studies claim that gentamicin is the “drug of choice” for inner ear perfusion, but others contradict this 39–41.…”

“…There is certainly some recovery after the initial insult to the labyrinth, but a small amount of permanent effect is usually observed. The transient disequilibrium, or “deafferentation syndrome,”37 that many patients experience after aminoglycoside perfusion is not usually seen until 3 to 7 days later but almost always resolves within days to weeks. After this, most patients report significant improvement in vertigo and aural fullness, and less commonly in hearing and tinnitus, usually for a period of at least several months.…”

“…After this, most patients report significant improvement in vertigo and aural fullness, and less commonly in hearing and tinnitus, usually for a period of at least several months. How much of this effect with subablative doses of streptomycin is due to destruction of type I hair cells versus inhibition of dark cell function and endolymph production is unclear 37. Patients will often have a lower summating potential—to—action potential ratio on the electrocochleogram following SDIEP as objective evidence of improvement in their hydrops.…”

Manual Acupuncture Effect on Vertigo and Tinnitus in Patient with Labyrinthitis: A Case Report

“…Penusukan pada titik akupunktur dapat mengaktifkan serabut saraf dan reseptor aferen, menghasilkan interaksi sensoris di berbagai tingkat sistem saraf pusat serta melepaskan berbagai transmiter dan modulator sehingga menghasilkan sinyal anti-inflamasi, sinyal neuroendokrin dan neuroimun (Cho et al, 2006;Bracey, 2009;Lalwani & McGuire, 2010).…”