Pharmacologic erection with intracavernosal injection for men with sexual dysfunction following irradiation: A preliminary report

Pierce, Lori J.; Whittington, Richard; Hanno, Philip M.; English, Wendy; Wein, Alan J.; Goodman, Robert L.

doi:10.1016/0360-3016(91)90291-b

Cited by 22 publications

(6 citation statements)

References 13 publications

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“…Treatment of post-radiation ED with intracavernosal injections was highly effective in one small study [103]. Dubocq et al reported a high satisfaction rate and low morbidity in 34 patients with a penile implant [104].…”

Section: Radiotherapymentioning

confidence: 98%

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Cancer and Sexual Problems

Sadovsky

Basson

Krychman

et al. 2010

The Journal of Sexual Medicine

264

198

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Introduction There are many data on sexual problems subsequent to cancer and its treatment, although the likelihood of problems in specific individuals depends on multiple variables. Aims To gain knowledge about the risks of sexual problems among persons with cancer and to provide recommendations concerning their prevention and optimal treatment. Methods A committee of multidisciplinary specialists was formed as part of a larger International Consultation working with urologic and sexual medicine societies over a 2-year period to review the result of chronic illness management on sexual function and satisfaction. The aims, goals, data collection techniques, and report format were defined by a central committee. Main Outcomes Measures Expert consensus was based on evidence-based medical and psychosocial literature review, extensive group discussion, and an open presentation with a substantial discussion period. Results Cancer and cancer treatments have both direct and indirect effects on physiologic, psychological, and interpersonal factors that can all impact negatively on sexual function and satisfaction. Data on the likelihood of specific sexual problems occurring with cancer and its management vary depending on prediagnosis function, patient response, support from the treatment team, specific treatments used, proactive counseling, and efforts to mitigate potential problems. This summary details available literature concerning the pathophysiologic and psychological impacts of cancer diagnosis and treatment on sexual function, plus recommendations for their prevention and management. Conclusions Cancer and its management have a significant negative impact on sexual function and satisfaction. These negative effects can be somewhat mitigated by understanding prediagnosis sexual functioning level, counseling, careful treatment choices, and, when indicated, therapy post-treatment using educational, psychological, pharmacologic, and mechanical modalities.

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Section: Radiotherapymentioning

confidence: 98%

“…Treatment of post‐radiation ED with intracavernosal injections was highly effective in one small study [103]. Dubocq et al.…”

Section: Cancer In Menmentioning

confidence: 99%

Cancer and Sexual Problems

Sadovsky

Basson

Krychman

et al. 2010

The Journal of Sexual Medicine

264

198

View full text Add to dashboard Cite

show abstract

“…Pierce et al reported on eight patients who used an ICI of phentolamine and papaverine [52]. All patients had erections sufficient for vaginal penetration with an ICI.…”

Section: Therapy Of Post-radiation Erectile Dysfunctionmentioning

confidence: 99%

Sexual function after external-beam radiotherapy for prostate cancer: What do we know?

Incrocci

2006

Critical Reviews in Oncology/Hematology

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“…This possibly was due to the slow progression of radiation and natural aging effects of these patients [115]. Radiation therapy-induced impotence often can be effectively treated with intracavernosal injection of prostaglandin [116] or oral sildenafil [117]. In 114 patients treated with IMRT to a dose that was higher than conventional, the acute RTOG grade-1 and -2 GI and GU toxicities were seen in 66% and 83% of the patients, respectively [118].…”

Section: Toxicity Of Radiation Therapymentioning

confidence: 96%

The efficacy of conventional external beam, three-dimensional conformal, intensity-modulated, particle beam radiation, and brachytherapy for localized prostate cancer

Eng

Luh²,

Thomas³

2005

Curr Urol Rep

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Technologic advances in radiation treatment planning and delivery have generated popular interest in the different radiation therapy techniques used in treating patients with localized prostate cancer. Throughout the past decade, high-energy (> 4 MV) linear accelerators have largely replaced Cobalt machines in external beam radiation therapy (EBRT) delivery. Conventional EBRT has been used to treat prostate cancer successfully since the 1950s. By switching to computed tomography-based planning, three-dimensional conformal radiation therapy provides better relative conformality of dose than does conventional EBRT. Intensity-modulated radiation therapy (IMRT) has further refined dose conformality by spreading the low-dose region to a larger volume. However, the potential long-term risks of larger volumes of normal tissues receiving low doses of radiation in IMRT are unknown. Particle-beam radiation therapy offers unique dose distributions and characteristics with higher relative biologic effect and linear energy transfer. Transperineal prostate brachytherapy offers the shortest treatment time with equivalent efficacy without significant risk of radiation exposure. The addition of hormonal therapy to radiation therapy has been shown to improve the outcome of radiation therapy.

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Pharmacologic erection with intracavernosal injection for men with sexual dysfunction following irradiation: A preliminary report

Cited by 22 publications

References 13 publications

Cancer and Sexual Problems

Cancer and Sexual Problems

Sexual function after external-beam radiotherapy for prostate cancer: What do we know?

The efficacy of conventional external beam, three-dimensional conformal, intensity-modulated, particle beam radiation, and brachytherapy for localized prostate cancer

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