Pharmacologic Management of Temporomandibular Disorders

Hersh, Elliot V.; Balasubramaniam, Ramesh; Pinto, Andrés

doi:10.1016/j.coms.2007.12.005

Cited by 98 publications

(108 citation statements)

References 93 publications

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“…33 Conservative treatment modalities, should be practiced and high rate of success has been achieved through the conservative approach also. 67,68 Further studies having sufficient number of cases and controls and especially longitudinal studies are needed to establish the relationship between occlusal features and craniocervical postures and vice versa. Current systemic literature reviews did not support the use of irreversible occlusal therapies for treatment of TMD or/prevention of TMD.…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular dentistry: Occlusal diseases and posture

Khan

Verma

Maheshwari

et al. 2013

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 99%

Neuromuscular dentistry: Occlusal diseases and posture

Khan

Verma

Maheshwari

et al. 2013

Journal of Oral Biology and Craniofacial Research

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“…Many of the surgical and dental therapies suggested for TMJ disorders have no scientifically proven effect;[67] therefore, pharmacotherapy is the primary intervention in patients with TMJ disorder. [6] Although pharmacotherapy is not curative for these patients it helps them to manage dysfunction and discomfort caused by such a chronic disorder.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Glucosamine sulfate and Ibuprofen effects in patients with temporomandibular joint osteoarthritis symptom

et al. 2013

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Objective:Ibuprofen – a non-steroidal anti-inflammatory drug (NSAID)- and glucosamine sulfate – a natural compound and a food supplement- are two therapeutic agents which have been widely used for treatment of patients with temporomandibular joint (TMJ) disorders. This study was aimed to compare the effectiveness and safety of these two medications in the treatment of patients suffering from TMJ disorders.Methods:After obtaining informed consent, 60 patients were randomly allocated to two groups. Patients with painful TMJ, TMJ crepitation or limitation of mouth opening entered the study. Exclusion criteria were history of depressive disorders, cardiovascular disease, musculoskeletal disorders, asthma, gastrointestinal problems, kidney or liver dysfunction or diabetes mellitus, dental diseases needing ongoing treatment; taking aspirin or warfarin, or concomitant treatment of TMJ disorder with other agents or methods. Thirty patients were treated with ibuprofen 400 mg twice a day, (mean age 27.12 ± 10.83 years) and 30 patients (mean age 26.60 ± 10) were treated with glucosamine sulfate 1500 mg daily. Patients were visited 30, 60 and 90 days after starting the treatment, pain and mandibular opening were checked and compared within and between two groups.Findings:Comparing with baseline measures, both groups had significantly improved post-treatment pain (P < 0.0001 for both groups) and mandibular opening (P value: 0.001 for glucosamine sulfate and 0.03 for ibuprofen). Post treatment pain and mandibular opening showed significantly more improvement in the glucosamine treated patients (P < 0.0001 and 0.01 respectively). Rate of adverse events was significantly lower in the P value glucosamine sulfate group (P < 0.0001).Conclusion:This investigation demonstrated that comparing with a commonly prescribed NSAID – ibuprofen-, glucosamine sulfate is a more effective and safer therapeutic agent for treatment of patients with TMJ degenerative join disorder.

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“…(77) NSAIDs are first-line management given for 10 to 14 days for initial treatment of acute pain. (78)(79)(80) Despite the multiple choices of NSAIDs available, only naproxen has proven benificial in reduction of pain. (79) Muscle relaxants can be prescribed with NSAIDs if there is evidence of a muscular cause of TMD.…”

Section: Mini Anterior Appliances:itengage Only a Small Number Of Maxmentioning

confidence: 99%

“…Benzodiazepines are also used for two to four weeks in the initial phase of treatment. (78,82) Ibuprofen is effective inskeletomuscular pains (dosage: 600 -800 mg three times daily). (36) Opioids should be used cautiously because of the potential for dependence.…”

Section: Mini Anterior Appliances:itengage Only a Small Number Of Maxmentioning

confidence: 99%