Pharmacologic Principles

Dowling, Patricia M.

doi:10.1016/b0-72-169777-1/50006-8

Cited by 4 publications

(2 citation statements)

References 351 publications

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“…According to the four veterinarians we interviewed, ceftiofur, a beta-lactam (Dowling, 2004 ), was the most frequently prescribed antibiotic for disease treatment (Dowling, 2004 ). Other antibiotics that veterinarians prescribe are enrofloxacin, florfenicol, tulathromycin, and oxytetracycline.…”

Section: Resultsmentioning

confidence: 99%

Identifying sources of antibiotic resistance genes in the environment using the microbial Find, Inform, and Test framework

Wiesner-Friedman,

Beattie,

Stewart

et al. 2023

Front. Microbiol.

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IntroductionAntimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined.MethodsTo identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region.ResultsA one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application of biosolids, sludge, and industrial wastewater (i.e., food processing) and domestic (i.e., municipal and septage)] was associated with 34–80% and 33–77% increases in the relative abundances of the ARGs in riverbed sediment and surface water, respectively. Sources influenced environmental AMR at overland distances of up to 13 km.DiscussionOur study corroborates previous evidence of offsite migration of microbial pollution from bovine sources and newly suggests offsite migration from land-applied waste. With FIT, we estimated the distance-based influence range overland and downstream around sources to model the impact these sources may have on AMR at unsampled sites. This modeling supports targeted monitoring of AMR from sources for future exposure and risk mitigation efforts.

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Section: Resultsmentioning

confidence: 99%

Identifying sources of antibiotic resistance genes in the environment using the microbial Find, Inform, and Test framework

Wiesner-Friedman,

Beattie,

Stewart

et al. 2023

Front. Microbiol.

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“…Ceftiofur was chosen instead of penicillin to increase the antimicrobial spectrum and to avoid that a possible previous sensibilisation to penicillin would induce or worsen seizure-like activity (Dowling 2010). We chose to use steroid and NSAIDs to have an effect on all levels of the anti-inflammatory cascade (Muir 2004).…”

Section: Discussionmentioning

confidence: 99%

Acquired epilepsy in a horse associated with colic surgery

Rovel

Chahory

Trachsel

2015

Vet Record Case Reports

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Literature is sparse about seizures in adult horses and this affection often carries a poor prognosis for further riding or athletic use. The authors present a case of an adult horse showing recurrent focal seizures and neurological deficits indicative of central blindness occurring during an episode of colic which was resolved surgically. Clinical signs occurred soon after an episode of colic, then resolved by laparotomy with an uneventful general anaesthesia. The investigations undertaken to find the cause of the seizures concluded finally a tentative diagnosis of a cortical lesion associated with amaurosis due to possible brain hypoxia and/or trauma. The outcome of the presented case was satisfactory, as four months later on a control examination no further seizures had been reported, most neurological deficits had disappeared and vision had at least partially been restored.

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