Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins

Assem, E. S. K.; Peh, K. H.; Wan, B. Y. C.; Manaviazar, Soraya; Walters, Marcus; George, Jestin; Hale, Karl J.

doi:10.1007/s00011-007-0610-6

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…It contracts ileum [5] and colonic smooth muscle, as reported here. It also inhibits histamine release from RBL-2H3 cells, a type of mucosal mast cell [6,7].…”

Section: Introductionmentioning

confidence: 59%

Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction

et al. 2009

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Contraction by stimulants used to induce Gpcc is known to involve G-proteins. All four test compounds-MGCD0103, alpha-lipoic acid and two of their hybrids, UCL M084 and UCL M109-reduced Gpcc induced by NaF and carbachol, suggesting that G-protein pathway involvement is relevant to the action of the test compounds, as is also indicated by the Bcl-induced inhibition of hydrogen peroxide-induced contractions. Additionally, alpha-lipoic acid and the two hybrids showed >30% inhibition of hydrogen peroxide-induced contractions, consistent with the antioxidant properties of the 1,2-dithiolane ring.

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“…It contracts ileum [5] and colonic smooth muscle, as reported here. It also inhibits histamine release from RBL-2H3 cells, a type of mucosal mast cell [6,7].…”

Section: Introductionmentioning

confidence: 59%

Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction

et al. 2009

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“…Many of these peptides and their diazacycloalkane building blocks have useful biological activities. [14][15][16][17][18][19]…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Cyclic Hydrazino α-Carboxylic Acids

Küchenthal¹,

Maison²

2010

Synthesis

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We present a review of different methods for the preparation of five-and six-membered cyclic hydrazino a-carboxylic acids and their derivatives. These heterocycles are common building blocks in pharmaceuticals and many natural products. In addition, hydrazino carboxylic acids have been used as auxiliaries and intermediates in organic syntheses and selected applications are highlighted in this summary. For six-membered heterocycles (piperazic acids), the literature since 1998 is covered as a follow-up to the review by Ciufolini and Xi.

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“…As a stem cell, mast cells play an important role in the growth and establishment of human tumor cells . Thus, scientists believed that tumor derived exosomes can reprogram mast cells to promote host immunosuppression, subvert T-regulatory cell function, and behave like malignant tumor cells. − This suggests the possibility of a specific antitumor drug therapy that returns the tumor-associated mast cells to their normal function by exposure to small molecules …”

mentioning

confidence: 99%

De Novo Asymmetric Synthesis of (+)-Monanchorin

O’Doherty

2015

Org. Lett.

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A de novo asymmetric total synthesis of the guanidine alkaloid natural product (+)-monanchorin has been achieved in nine steps from the commodity chemicals furan and caproic acid. The asymmetry of the route was introduced by a Noyori reduction of an acylfuran. In addition, this route relies upon an Achmatowicz rearrangement, a diastereoselective palladium catalyzed glycosylation, reductive amination, and an acid catalyzed bicyclic guanidine mixed acetal formation.

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Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins

Cited by 5 publications

References 6 publications

Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction

Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction

Synthesis of Cyclic Hydrazino α-Carboxylic Acids

De Novo Asymmetric Synthesis of (+)-Monanchorin

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