2017
DOI: 10.1248/bpb.b17-00383
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Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes

Abstract: A significant reduction of glial cell line-derived neurotrophic factor (GDNF) has been identified in the pathophysiology of neurodegenerative and neuropsychiatric disorders. Thus, clarification of the mechanism of GDNF production, and modulating brain GDNF levels could be a novel therapeutic approach. A previous study demonstrated that antidepressant amitriptyline-induced GDNF production was significantly inhibited by pertussis toxin (PTX), a Gi/o protein inhibitor in astrocytes, the main source of GDNF in the… Show more

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Cited by 4 publications
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“…Potential cytotoxicity of LPA in astrocyte was evaluated by the tetrazolium salt 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide (MTT; Sigma‐Aldrich Co., ) assay as described previously (Hisaoka‐Nakashima et al., 2017). Cell viability was not affected by concentrations of LPA as determined by the MTT assay (Figure S3).…”
Section: Methodsmentioning
confidence: 99%
“…Potential cytotoxicity of LPA in astrocyte was evaluated by the tetrazolium salt 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide (MTT; Sigma‐Aldrich Co., ) assay as described previously (Hisaoka‐Nakashima et al., 2017). Cell viability was not affected by concentrations of LPA as determined by the MTT assay (Figure S3).…”
Section: Methodsmentioning
confidence: 99%