Pharmacological activities of fusaric acid (5-butylpicolinic acid)

Wang, Hexiang; Ng, T.B.

doi:10.1016/s0024-3205(99)00083-1

Cited by 64 publications

(48 citation statements)

References 34 publications

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“…This is further evidence of the ecological importance of interspecies and interphylum signaling that is only now being uncovered. Mycotoxins produced by Fusarium spp., including fusaric acid, typically have broad-spectrum antibiotic activity affecting bacteria, fungi, nematodes, insects, and mammals (39, 67), and their activity can be synergistic (13). An unexpectedly diverse range of Fusarium species have been found to produce fusaric acid and other mycotoxins in environments that require aggressive saprophytic competition with other organisms (i.e., grain [2] and crop residues [36]).…”

mentioning

confidence: 99%

Potential Role of Pathogen Signaling in Multitrophic Plant-Microbe Interactions Involved in Disease Protection

Duffy¹,

Keel

Défago

2004

Appl Environ Microbiol

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Multitrophic interactions mediate the ability of fungal pathogens to cause plant disease and the ability of bacterial antagonists to suppress disease. Antibiotic production by antagonists, which contributes to disease suppression, is known to be modulated by abiotic and host plant environmental conditions. Here, we demonstrate that a pathogen metabolite functions as a negative signal for bacterial antibiotic biosynthesis, which can determine the relative importance of biological control mechanisms available to antagonists and which may also influence fungus-bacterium ecological interactions. We found that production of the polyketide antibiotic 2,4-diacetylphloroglucinol (DAPG) was the primary biocontrol mechanism of Pseudomonas fluorescens strain Q2-87 against Fusarium oxysporum f. sp. radicis-lycopersici on the tomato as determined with mutational analysis. In contrast, DAPG was not important for the less-disease-suppressive strain CHA0. This was explained by differential sensitivity of the bacteria to fusaric acid, a pathogen phyto-and mycotoxin that specifically blocked DAPG biosynthesis in strain CHA0 but not in strain Q2-87. In CHA0, hydrogen cyanide, a biocide not repressed by fusaric acid, played a more important role in disease suppression.

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mentioning

confidence: 99%

Potential Role of Pathogen Signaling in Multitrophic Plant-Microbe Interactions Involved in Disease Protection

Duffy¹,

Keel

Défago

2004

Appl Environ Microbiol

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“…FA has many different pharmacological effects [ 59 ], as demonstrated on neurotransmitters in the brain. Its presence in the diet elevated the level of serum melatonin in pineal cell monolayer cultures [ 60 ].…”

Section: Fusaric Acidmentioning

confidence: 99%

Fusarins and Fusaric Acid in Fusaria

et al. 2014

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“…[ 22 ] The other molecule that interacted with LF, fusaric acid, is not FDA-approved but it is being studied for various medical apllicatioons. [ 23 ] Using a competition magnetic relaxation assay, we were able to estimate the dissociation constant between LF and the corresponding molecules ( Figure 1 d-f). Sulindac showed the strongest interaction binding to LF with a K D of 2.8 μ M. Fusaric acid was the second strongest binder to LF with a dissociation constant of 4.5 μ M, followed by naproxen with a K D of 10.8 μ M. These K D values further confi rmed that these three molecules strongly interact to the LF toxin while being attached to the nanoparticles.…”

Section: Screening Of the Bmr Nanosensors Library For Binding To Anthmentioning

confidence: 99%

Identification of Toxin Inhibitors Using a Magnetic Nanosensor‐Based Assay

Santiesteban

Kaittanis

Perez

2013

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A magnetic nanosensor-based method is described to screen a library of drugs for potential binding to toxins. Screening is performed by measuring changes in the magnetic relaxation signal of the nanosensors (bMR nanosensors) in aqueous suspension upon addition of the toxin. The Anthrax lethal factor (ALF) is selected as a model toxin to test the ability of our bMR nanosensor-based screening method to identify potential inhibitors of the toxin. Out of 30 molecules screened, sulindac, naproxen and fusaric acid are found to bind LF, with dissociation constants in the low micromolar range. Further biological analysis of the free molecules in solution indicate that sulindac and its metabolic products inhibited LF cytotoxicity to macrophages with IC50 values in the micromolar range. Meanwhile, fusaric acid is found to be less effective at inhibiting LF cytotoxicity, while naproxen does not inhibit LF toxicity. Most importantly, when the sulindac and fusaric acid-bMR nanosensors themselves are tested as LF inhibitors, as opposed to the corresponding free molecules, they are stronger inhibitors of LF with IC50 values in the nanomolar range. Taken together, these studies show that a bMR nanosensors-based assay can be used to screen known drugs and other small molecules for inhibitor of toxins. The method can be easily modified to screen for inhibitors of other molecular interactions and not only the selected free molecule can be study as potential inhibitors but also the bMR nanosensors themselves achieving greater inhibitory potential.

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Pharmacological activities of fusaric acid (5-butylpicolinic acid)

Cited by 64 publications

References 34 publications

Potential Role of Pathogen Signaling in Multitrophic Plant-Microbe Interactions Involved in Disease Protection

Potential Role of Pathogen Signaling in Multitrophic Plant-Microbe Interactions Involved in Disease Protection

Fusarins and Fusaric Acid in Fusaria

Identification of Toxin Inhibitors Using a Magnetic Nanosensor‐Based Assay

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