Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs

Fonseca, Roberto J. C.; Mourāo, Paulo A.S.

doi:10.3390/md19080425

Cited by 21 publications

(11 citation statements)

References 94 publications

(92 reference statements)

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“…Multiple biological actions of fucoidans depend primarily on their interaction with different proteins due to the presence of sulfate groups [ 15 , 16 , 17 , 18 , 19 ], but branching of molecules [ 20 ] and molecular weights [ 21 , 22 ] may also be very important factors. Fucoidans are traditionally regarded as promising anticoagulant [ 23 , 24 , 25 , 26 ], antitumor [ 27 , 28 ] and anti-inflammatory agents [ 29 , 30 , 31 , 32 , 33 ], but recently they acquired special importance as potential components of antiviral drugs [ 34 , 35 , 36 ], activators of hematopoiesis [ 37 , 38 ], and reagents for use in nanomedicine [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Fucoidans of Brown Algae: Comparison of Sulfated Polysaccharides from Fucus vesiculosus and Ascophyllum nodosum

et al. 2022

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Preparations of sulfated polysaccharides obtained from brown algae are known as fucoidans. These biopolymers have attracted considerable attention due to many biological activities which may find practical applications. Two Atlantic representatives of Phaeophyceae, namely, Fucus vesiculosus and Ascophyllum nodosum, belonging to the same order Fucales, are popular sources of commercial fucoidans, which often regarded as very similar in chemical composition and biological actions. Nevertheless, these two fucoidan preparations are polysaccharide mixtures which differ considerably in amount and chemical nature of components, and hence, this circumstance should be taken into account in the investigation of their biological properties and structure–activity relationships. In spite of these differences, fractions with carefully characterized structures prepared from both fucoidans may have valuable applications in drug development.

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Section: Introductionmentioning

confidence: 99%

Fucoidans of Brown Algae: Comparison of Sulfated Polysaccharides from Fucus vesiculosus and Ascophyllum nodosum

et al. 2022

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“…Sulfates in fixed positions and variable substituents R are highlighted in red. peutic effect of fucoidans and other polysaccharides with a high fucose content [14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome

Kiselevskiy

Anisimova²,

Bilan³

et al. 2022

Russ J Bioorg Chem

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Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. The clinical picture of COVID-19 is heterogeneous and involves most physiological systems; therefore, drugs with a wide spectrum of mechanism of action are required. The choice of the treatment strategy for post-COVID-19 syndrome is still a challenge to be resolved. Polysaccharides with a high fucose content derived from seaweed and marine animals can form the basis for the subsequent development of promising agents for the treatment of COVID-19 and post-COVID-19 syndrome. This class of biopolymers is characterized by a variety of biological activities, including antiviral, antithrombotic, anticoagulant, hemo-stimulating, anti-inflammatory and immune-regulatory. Low molecular weight derivatives of these polysaccharides, as well as synthetic oligosaccharides with a sufficient amount and sulfation type may be considered as the most promising compounds due to their better bioavailability, which undoubtedly increases their therapeutic potential.

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“…These examples demonstrate high structural diversity of FCSs. Since investigation of FCSs is connected with their promising biological activities [16][17][18][19], it is clear that different biological properties of FCS should depend on their fine structural characteristics, such as degree and position of sulfation, nature and position of branches and molecular mass distribution.…”

Section: Introductionmentioning

confidence: 99%

“…Natural fucose-enriched sulfated polysaccharides exerted excellent anticoagulant, antithrombotic, antivirus and anticancer activity together with many other biological actions [15][16][17][18][19]. Holothurian FCSs and FSs are isolated and characterized in order to find new biopolymers of practical importance and to establish distinct structure-activity correlations in these unique biologically active biopolymers.…”

Section: Introductionmentioning

confidence: 99%

Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

et al. 2022

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Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively. Purification of the polysaccharides was carried out by anion-exchange chromatography on DEAE-Sephacel column. Structural characterization of polysaccharides was performed in terms of monosaccharide and sulfate content, as well as using a series of non-destructive NMR spectroscopic methods. Both FCSs were shown to contain a chondroitin core [→3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→]n bearing sulfated fucosyl branches at O-3 of every GlcA residue in the chain. These fucosyl residues were different in pattern of sulfation: FCS-BA contained Fuc2S4S, Fuc3S4S and Fuc4S at a ratio of 1:8:2, while FCS-HS contained these residues at a ratio of 2:2:1. Polysaccharides differed also in content of GalNAc4S6S and GalNAc4S units, the ratios being 14:1 for FCS-BA and 4:1 for FCS-HS. Both FCSs demonstrated significant anticoagulant activity in clotting time assay and potentiated inhibition of thrombin, but not of factor Xa. FS-BA-AT was shown to be a regular linear polymer of 4-linked α-L-fucopyranose 3-sulfate, the structure being confirmed by NMR spectra of desulfated polysaccharide. In spite of considerable sulfate content, FS-BA-AT was practically devoid of anticoagulant activity. FS-HS-AT cannot be purified completely from contamination of some FCS. Its structure was tentatively represented as a mixture of chains identical with FS-BA-AT and other chains built up of randomly sulfated alternating 4- and 3-linked α-L-fucopyranose residues.

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Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs

Cited by 21 publications

References 94 publications

Fucoidans of Brown Algae: Comparison of Sulfated Polysaccharides from Fucus vesiculosus and Ascophyllum nodosum

Fucoidans of Brown Algae: Comparison of Sulfated Polysaccharides from Fucus vesiculosus and Ascophyllum nodosum

Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome

Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

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