Pharmacological activities on<i>Ephedra nebrodensis</i>Tineo

Ballero, Mauro; Foddis, Caterina; Sanna, Cinzia; Scartezzini, Paolo; Poli, Ferruccio; Petitto, Valentina; Serafini, Mauro; Stanzione, Alessandra; Bianco, Armandodoriano; Serilli, Anna Maria; Spina, Liliana; Longoni, R; Kasture, Sanjay

doi:10.1080/14786410802680902

Cited by 9 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, Ephedra nebrodensis, which has the lowest distribution, can be found in North Africa [56], Europe (▶ Fig. 2 e) [57], including Italy [58,59] and Spain [52], Morocco [60], and Algeria [61]. Here, we will focus on Moroccan Ephedra species.…”

Section: Resultsmentioning

confidence: 99%

“…A 1 : 1 ethanolic : acetone crude extract prepared from the aerial parts of a plant sample collected in Urzulei (Sardinia, Italy) has shown antioxidant and hypotensive effects, as well as antinociceptive and anti-inflammatory activities. The presence of ephredrine-type alkaloids was suspected [59]. The presence of ephedrine and pseudoephedrine (▶ Fig.…”

Section: Ephedra Fragilismentioning

confidence: 99%

See 1 more Smart Citation

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

View full text Add to dashboard Cite

Ephedra species are among the most popular herbs used in traditional medicine for a long time. The ancient Chinese medical book “Treatise on Febrile Diseases” refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species. Ephedra species are utilized all over the world to treat symptoms of the common cold and coughs, and to combat major human diseases, such as asthma, cancers, diabetes, cardiovascular and digestive disorders, and microbial infections. This study aimed at identifying specific Ephedra species used traditionally in Morocco for therapeutic purposes. The plant parts, their preparation process, and the treated pathologies were identified and analyzed. The results revealed five ethnobotanically important species of Ephedra: Ephedra alata Decne, Ephedra altissima Desf., Ephedra distachya L., Ephedra fragilis Desf., and Ephedra nebrodensis Tineo. These species are used traditionally in Morocco for treating people with diabetes, cancer, rheumatism, cold and asthma, hypertension, influenza virus infection, and respiratory ailments. In addition, they are occasionally used as calefacient agents, to regulate weight, or for capillary care. Few studies have underlined the antibacterial and antioxidant activities of some of these Moroccan Ephedra species, but little information is available regarding the natural products at the origin of the bioactivities. Further phytochemical investigations and clinical data are encouraged to better support the use of these plants.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Ephedra Fragilismentioning

confidence: 99%

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

View full text Add to dashboard Cite

show abstract

“…It is reported that phenolic compounds possess free radical scavenging properties (Tabassum et al, 2017). E. nebrodensis has been also reported for its antioxidant potential (Ballero et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Extraction optimization, Total Phenolic-Flavonoids content, HPLC-DAD finger printing, antimicrobial, antioxidant and cytotoxic potentials of Chinese folklore Ephedra intermedia Schrenk & C. A. Mey

Nasar

Zohra

Khalil

et al. 2022

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Plants from genus Ephedra are commonly used by the Chinese people as folk medicine for treatment of various diseases. The current study was designed to explore the ethno-pharmacological based pharmacological potentials of Ephedra intermedia Schrenk & C.A. Mey. (E. intermedia). Plant aerial parts were extracted using ten solvent systems with increasing order of polarity. Samples were analyzed for total phenolic and flavonoid contents, HPLC-DAD analysis, antibacterial, antifungal, HepG2 cell line cytotoxicity, hemolysis and antioxidant potentials following standard procedures. Highest percent extract recovery was observed in Eth+WT (25.55 % w/w) solvent system. Flavonoid and phenolic contents were higher in chloroform and Met+WT fractions respectively. Considerable antibacterial activity was shown by Eth+Met extract against B. subtilis and K. pneumonia (MIC of 11.1μg/mL for each). Eth extract exhibited high antifungal activity against A. fumigates (15±0.31 mm DIZ). Met+WT extract showed significant cytotoxicity against HepG2 cell lines with IC 50 of 13.51+0.69 μg/mL. Substantial free radical scavenging activity (74.9%) was observed for Met+Eth extract. In the current study, several solvent systems were used for more effective extraction of fractions and can be useful in the isolation of phytochemicals. Various fractions exhibited considerable antimicrobial, antioxidant and cytotoxic potentials. Biological potentials of E. intermedia signify its potential uses in microbial, cancer and degenerative disorders and thus warrant further detailed studies.

show abstract

“…DMSO was the vehicle used for the dissolution of plant extracts, and its final concentration in the cells was less than 0.2%. (18)(19)(20). The percentage change in viability was calculated according to the following formula: ((reading of extract/reading of negative control) − 1) × 100.…”

Section: Cell Viability Assay Mttmentioning

confidence: 99%

Bio-Guided Assay of Ephedra foeminea Forssk Extracts and Anticancer Activities: In Vivo, In Vitro, and In Silico Evaluations

Nazeam,

Boshra,

Mohammed

et al. 2023

Molecules

View full text Add to dashboard Cite

Ephedra is one of the oldest known medicinal plants and the largest genera of the Ephedraceae family. In vivo antitumor evaluation of Ephedra foeminea revealed that ethyl acetate (EtOAc) was the most bioactive fraction. Bio-guided fractionation of EtOAc fraction afforded nine compounds isolated for the first time from the plant species. Macrocyclic spermine alkaloids (1,9), proanthocyanidins (2,4,5), quinoline alkaloids (7,8), phenolic (3), and nucleoside (6) were identified and elucidated by spectroscopic analyses including 1D and 2D NMR, ESI-MS-MS spectrometry. The tested compounds exhibited moderate anticancer activity, except for the kynurenic acid derivative (6-mKYNA) which showed significant cytotoxicity and remarkable inhibition of CA-19.9 and CA-125 tumor biomarkers. In-silico study was conducted to determine the anti-proliferative mechanism of 6-mKYNA by using the CK2 enzyme active site. Moreover, the ADME computational study suggested that 6-mKYNA is an effective candidate with a promising pharmacokinetic profile and therapeutic potential against various types of cancer.

show abstract

Pharmacological activities onEphedra nebrodensisTineo

Cited by 9 publications

References 20 publications

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Extraction optimization, Total Phenolic-Flavonoids content, HPLC-DAD finger printing, antimicrobial, antioxidant and cytotoxic potentials of Chinese folklore Ephedra intermedia Schrenk & C. A. Mey

Bio-Guided Assay of Ephedra foeminea Forssk Extracts and Anticancer Activities: In Vivo, In Vitro, and In Silico Evaluations

Contact Info

Product

Resources

About