Pharmacological activity and mechanism of pyrazines

Hou, Wen; Dai, Wei; Hao, Hongxun; Liu, Shenglan; Li, Jun; Huang, Le-Jun; Huang, Xianhua; Zeng, Jun-Lin; Gan, Zongsong; Zhang, Z.; Lan, Jin-Xia

doi:10.1016/j.ejmech.2023.115544

Cited by 27 publications

(7 citation statements)

References 131 publications

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“…The direct pharmacological targets of sinomenine in terms of its anti-inflammatory, antitumor, and immunosuppressive effects are not fully understood, warranting more exploration of its potential molecular targets and antitumor and pharmacological mechanisms both in vivo and in vitro. Techniques such as chemical proteomics [ 228 ], photoaffinity chromatography [ 229 ], and drug affinity responsive target stability assays [ 230 ] can be utilized to investigate the intrinsic mechanisms of sinomenine and its derivatives, offering scientific explanations for any toxic side effects associated with certain derivatives [ 231 ].…”

Section: Conclusion or Concluding Remarksmentioning

confidence: 99%

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Hou,

Huang,

Huang

et al. 2024

Molecules

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Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC50 values of approximately 121.4 nM against PC-3 and DU-145 cells, primarily through the PI3K/Akt/mTOR, NF-κB, MAPK, and JAK/STAT signaling pathways. Additionally, they manifest anti-inflammatory and analgesic effects predominantly via the NF-κB, MAPK, and Nrf2 signaling pathways. Utilized in treating rheumatic arthritis, these alkaloids also play a significant role in cardiovascular and cerebrovascular protection, as well as organ protection through the NF-κB, Nrf2, MAPK, and PI3K/Akt/mTOR signaling pathways. This review concludes with perspectives and insights on this topic, highlighting the potential of sinomenine-related compounds in clinical applications and the development of medications derived from natural products.

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Section: Conclusion or Concluding Remarksmentioning

confidence: 99%

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Hou,

Huang,

Huang

et al. 2024

Molecules

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“…Owing to nitrogen atoms acting as hydrogen bonding acceptors and the structure being conducive to nucleophilic reaction, pyrazine is commonly used as a classical pharmacophore [86]. Pyrazine derivatives have been reported for applications as antitumor drugs, diuretics, anti-inflammatory and anti-infective drugs [87].…”

Section: Pyrazinesmentioning

confidence: 99%

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Liu,

Sun,

et al. 2024

Marine Drugs

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Natural alkaloids originating from actinomycetes and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus. Marine-derived Streptomyces strains harbor unconventional metabolic pathways and have been demonstrated to be efficient producers of biologically active alkaloids; more than 60% of these compounds exhibit valuable activity such as antibacterial, antitumor, anti-inflammatory activities. This review comprehensively summarizes novel alkaloids produced by marine Streptomyces discovered in the past decade, focusing on their structural features, biological activity, and pharmacological mechanisms. Future perspectives on the discovery and development of novel alkaloids from marine Streptomyces are also provided.

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“…Fortunately, many advanced methods and technologies have been put forward by scientists to solve this difficult problem. Chemical proteomics technology and techniques, such as photoaffinity chromatography and drug affinity-responsive target stability, are resourceful examples for target fishing [73,74]. We are confident that, in the future, many more mechanisms of action for diphyllin and its derivatives will be revealed and reported by research groups.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Bioactivities and Mechanisms of Action of Diphyllin and Its Derivatives: A Comprehensive Systematic Review

Hou,

Huang,

Huang

et al. 2023

Molecules

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Natural products are treasure houses for modern drug discovery. Diphyllin is a natural arylnaphthalene lignan lactone isolated from the leaf of Astilboides tabularis. Studies have found that it possesses plenty of bioactivity characteristics. In this paper, we reviewed the structure, bioactivity, and mechanism of action of diphyllin and its derivatives. The references were obtained from PubMed, Web of Science, and Science Direct databases up to August 2023. Papers without a bio-evaluation were excluded. Diphyllin and its derivatives have demonstrated V-ATPase inhibition, anti-tumor, anti-virus, anti-biofilm, anti-inflammatory, and anti-oxidant activities. The most studied activities of diphyllin and its derivatives are V-ATPase inhibition, anti-tumor activities, and anti-virus activities. Furthermore, V-ATPase inhibition activity is the mechanism of many bioactivities, including anti-tumor, anti-virus, and anti-inflammatory activities. We also found that the galactosylated modification of diphyllin is a common phenomenon in plants, and therefore, galactosylated modification is applied by researchers in the laboratory to obtain more excellent diphyllin derivatives. This review will provide useful information for the development of diphyllin-based anti-tumor and anti-virus compounds.

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Pharmacological activity and mechanism of pyrazines

Cited by 27 publications

References 131 publications

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Bioactivities and Mechanisms of Action of Diphyllin and Its Derivatives: A Comprehensive Systematic Review

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