Pharmacological activity of 16-and 18-member dibenzodioxatetraaza macroheterocyclic compounds

Abstract

The spectrum of the biological activities (within the framework of the PASS program) that 16-and 18-member dibenzodioxatetraaza macroheterocyclic compounds might have is assessed. compounds of these classes were found to have anticonvulsant activity. 16-Member macrocyclic compounds could have antiaggregatory activity. These results lead to the conclusion that antiaggregatory and anticonvulsant substances may be found among similar macroheterocyclic compounds. 150091-150X/08/4201-0015 Compound ED 50 , mg/kg I (R 1 = Cl, R 2 = Ph) 80 [65¸92] I (R 1 = Me, R 2 = Ph) 80 [60¸98] II (R 1 = Cl, R 2 = o-Cl-C 6 H 4 ) 80 [55¸88]