Pharmacological activity of ziacryl, a zinc salt of polyacrylic acid

Абзаева, К. А.; Воронков, М. Г.; Zhilitskaya, L. V.; Буровик, Д. А.; Makarov, V. A.; Belozerskaya, G.G.

doi:10.1007/s11094-010-0376-y

Cited by 2 publications

(2 citation statements)

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“…These incomplete metallic salts of polyacrylic acid containing metal ions ( Table 1) correspond to the general formula (-CH 2 -СН-СOOH) n (-CH 2 -СН-СOOM) m , where n = 1200-3500; т = 1650-6650 and contain 4-8 mass% of a metal are colorless or colored films. They have been synthesized by the method of polymer analogous transformations of polyacrylic acid by organic and inorganic metal salts [2][3][4][5][6][7][8][9]. The molecular weight of these polymetalacrylates are in the range from 1000000 to 3000000 D. Absorbtion bands 1548-1540 сm -1 (ν as СОО -) и 1405-1410 сm -1 (ν s СОО -); 1694-1649 сm -1 (СООН), a widened band in the region 3420-2554 сm -1 , shifted in a lowfrequency field (associated OH).…”

Section: Compoundsmentioning

confidence: 99%

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Experimental Study of the Antitumor Activity of Polymetalacrylates against Animal Transplantable Tumors

Ostrovskaya¹,

Воронков²,

Корман³

et al. 2010

JCT

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The antitumor activity of the fourteen polymetalacrylates against two models of murine solid tumors (Lewis lung carcinoma and Acatol adenocarcinoma) as well as the acute toxicity of these compounds has been studied. It was shown that polyacrylates of noble metals (argent, aurum, platinum), namely argacryl (М = Ag), auracryl (М = Au) and platacryl (М = Pt) were the most effective agents among tested compounds against studied tumors. Thus, the tumor growth inhibitory effect of argacryl against Lewis lung carcinoma was equal to 90%, the life-span of treated by this compound animals has increased on 50% in comparison with control. Auracryl induced the inhibition of the Lewis lung carcinoma and Acatol adenocarcinoma development on 60 and 65%, correspondingly and the increasing of the mean life-span of animals with Lewis lung carcinoma on 20% in comparison with control. Platacryl inhibited the growth of Lewis lung carcinoma on 40% increasing the mean life-span of animals on 25% in comparison with control. In this way it was established that argacryl is the agent with the strongest antitumor activity among studied polymetalacrylates. On the basis of obtained data it seems possible to consider polymetalacrylates as a group of agents with the potential antitumor activity suitable for the further deep experimental investigation

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Section: Compoundsmentioning

confidence: 99%

“…In this field, the metal derivatives of polyacrylic acid (polymetalacrylates) are especially promising [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%