Pharmacological and analytical aspects of bergenin: a concise report

Patel, DK; Patel, Krutika; Kumar, Rajesh; Gadewar, Manoj; Tahilyani, V

doi:10.1016/s2222-1808(12)60037-1

Cited by 81 publications

(45 citation statements)

References 35 publications

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“…In Group I, at the right of the score plot, contained No.2 -No. 4 and No.7 samples. The Group II contained the rest of the tested samples, which were located on the left of the score plot.…”

Section: Pca Analysismentioning

confidence: 99%

“…Until now, RR has been extensively used as a traditional Chinese medicine (TCM) due to its explicit therapeutic effect for the treatment of bacillary dysentery, gastroenteritis and bronchitis [2]. Chemical investigations have demonstrated that polyphenols and saccharides were the main composition of this plant [3]; however, the quality control of the drug sample has only been evaluated by quantitative determination of bergenin, which was one of characteristic constituents in RR with pharmacological properties of cough-relieving, anti-HIV, antiarrhythmic and anti-inflammatory [4] [5] [6]. To date, studies with respect to the quality evaluation of the medicinal plant can rarely be found.…”

Section: Introductionmentioning

confidence: 99%

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Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

Yan¹,

Yang²

2017

AJAC

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In this paper, the feasibility and advantages of employing high performance liquid chromatographic-photodiode array detection (HPLC-DAD) fingerprint combined with chemical pattern recognition for quality consistency evaluation of widely used Rhizoma rodgersiae (RR) were investigated and demonstrated for the first time. The Similarity Evaluation System was employed to evaluate the similarities of 10 batches of RR sample; moreover, hierarchical clustering analysis (HCA) and principal component analysis (PCA) were also successfully applied to discriminate RR samples of different regions and seasons. Our results indicated that the seasonal variation had some influence on the chemical fingerprints of this herbal drug. This approach allowed the discrimination of RR samples from different sources. The current study demonstrated that fingerprint profiling coupled with chemical pattern recognition offered a reliable and efficient way to comprehensively assess the quality consistency of the tested samples.

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Section: Pca Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

Yan¹,

Yang²

2017

AJAC

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“…compounds such as flavonoids, phenolic compounds, terpenoids and phloroglucinol derivatives [5]. Moreover, the pharmaceutical research has found that some of chemical constituents of Mallotus have the capability to possess several biological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, cytotoxic and antitumor activities [3].…”

Section: -2506mentioning

confidence: 99%

“…Bergenin is a colourless crystalline polyphenol, which contains five hydroxyl groups that played an important role in its pharmacological activity [5]. This compound is reported in literature to exhibit various biological activities such as antifungal, antiulcer, burn wound healing effects and also immunomodulatory [6].…”

Section: Figure 1 Structure Of Isolated Compounds (1) Bergenin and (mentioning

confidence: 99%

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PHYTOCHEMICAL STUDY ON THE STEM BARK OF Mallotus leucodermis Hook F.

Yusoff

Ahmat

Naz³

2016

MJAS

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The stem barks of Mallotus leucodermis Hook F. (Euphorbiaceae) was studied for its chemical constituents. The air dried and pulverized of stem bark of M. leucodermis (1.3 kg) was extracted successively with acetone for three days at room temperature yielding 66.0 g of crude extract. The crude extract was fractionated using vacuum liquid chromatography (VLC) to afford six fractions. Fraction 6 was further washed and recrystallized to afford bergenin (1). Fraction 3 was subjected to multiple purification using radial chromatography (CHCl 3 : acetone) with different ratio 9:1, 8:2, 6:4 and 5:5 to yield a flavonoid compound, epicatechin (2). These compounds were elucidated based on spectroscopic analysis (Ultra Violate, Infra-Red, Mass Spectrometry and Nuclear Magnetic Resonance) as well as comparison with literatures. Keywords: Euphorbiaceae, Mallotus, bergenin, epicatechin AbstrakKulit ranting Mallotus leucodermis Hook F. (Euphorbicaeae) telah dikaji untuk sebatian kimianya. Kulit ranting M. leucodermis (1.3 kg) yang telah dikeringkan dan dikisar, direndamkan dalam aseton selama tiga hari pada suhu bilik bagi memperolehi 66.0 g bahan ekstrak. Fraksinasi telah dilakukan ke atas ekstrak tersebut dgn menggunakan hampagas kromatografi cecair dan menghasilkan enam fraksi. Fraksi 6 telah dicuci beberapa kali dan dihablurkan semula untuk menghasilkan bergenin (1). Manakala fraksi 3 ditulenkan beberapa kali menggunakan radial kromatografi untuk mendapatkan sebatian flavonoid, epicatechin (2). Dua sebatian tulen ini dikenal pasti berdasarkan analisis spektroskopi (Ultralembayung, Inframerah, Spektrometri Jisim and Resonans Magnet Nukleus) dan juga perbandingan data.

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Cross‐Coupling Reaction of Saccharide‐Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin

Parkan

Pohl

Kotora

2014

Chemistry A European J

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A convenient synthetic pathway enabling D-glucal and D-galactal pinacol boronates to be prepared in good isolated yields was achieved. Both pinacol boronates were tested in a series of cross-coupling reactions under Suzuki-Miyaura cross-coupling conditions to obtain the corresponding aryl, heteroaryl, and alkenyl derivatives in high isolated yields. This methodology was applied to the formal synthesis of the glucopyranoside moiety of papulacandin D and the first total synthesis of bergenin.

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Pharmacological and analytical aspects of bergenin: a concise report

Cited by 81 publications

References 35 publications

Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

PHYTOCHEMICAL STUDY ON THE STEM BARK OF Mallotus leucodermis Hook F.

Cross‐Coupling Reaction of Saccharide‐Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin

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Pharmacological and analytical aspects of bergenin: a concise report

Cited by 81 publications

References 35 publications

Development and Distinction of &lt;i&gt;Rhizoma rodgersiae&lt;/i&gt; with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

Development and Distinction of &lt;i&gt;Rhizoma rodgersiae&lt;/i&gt; with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

PHYTOCHEMICAL STUDY ON THE STEM BARK OF Mallotus leucodermis Hook F.

Cross‐Coupling Reaction of Saccharide‐Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin

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Product

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Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques

Development and Distinction of <i>Rhizoma rodgersiae</i> with HPLC-DAD Fingerprint Analysis Combined with Chemical Pattern Recognition Techniques