Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants

Miert, A. S. J. P. A. M. van; Duin, C. T. M. van

doi:10.1046/j.1365-2885.1998.00101.x

Cited by 12 publications

(4 citation statements)

References 162 publications

(293 reference statements)

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“…The authors concluded that 5‐HT 1 , 5‐HT 2 , 5‐HT 3 , and 5‐HT 4 receptors were all involved in regulation of the small intestinal migrating myoelectric complex (MMC) and on forestomach hypomotility occasionally recorded concomitantly to duodenal phase III activity. In goats, however, the 5‐HT 1 receptor agonist MDL‐72832 increased the rumen contraction rates (van Miert & van Duin, 1998). In a subsequent study, Plaza et al.…”

Section: Introductionmentioning

confidence: 99%

“…The findings suggest that in sheep, 5‐HT 4 receptor‐agonists act peripherally and are excitatory, while 5‐HT 3 agonists act centrally and are inhibitory. In goats, however, the peripheral 5‐HT 4 receptor agonist 5‐methoxytryptamine decreased rumen contraction rates (van Miert & van Duin, 1998). The literature demonstrating the involvement of 5‐HT receptors in abomasal motility and/or abomasal displacement in cattle is not available.…”

Section: Introductionmentioning

confidence: 99%

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Modification of spontaneous contractility of smooth muscle preparations from the bovine abomasal antrum by serotonin receptor agonists

Spring¹,

Mevissen

Reist³

et al. 2003

Vet Pharm & Therapeutics

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The effects of serotonin (5-hydroxytryptamine, 5-HT), a 5-HT2-receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-M-5-HT) and RS-67506, a 5-HT4 receptor partial agonist, on spontaneous contractility of bovine abomasal smooth muscle preparations were investigated in vitro. Preparations from the abomasal antrum of freshly slaughtered healthy dairy cows were cut parallel to the longitudinal fibres, suspended in isolated organ baths, and concentration-response curves were performed by cumulative application of the 5-HT receptor agonists. Blockade of 5-HT2-induced response was tested with atropine and hexamethonium. Serotonin evoked a significant increase in the area under curve (AUC), whilst the 5-HT2 receptor agonist alpha-M-5-HT significantly increased the AUC and resting tone (RT). RS-67506 induced a significant increase in AUC and RT and a significant decrease in the maximum force. The effect of alpha-M-5-HT was mediated by a muscarinic cholinergic pathway, as the effect of alpha-M-5-HT was inhibited in the presence of atropine but not hexamethonium. It is concluded that 5-HT2 and 5-HT4 receptors are present in the bovine abomasal antrum. Muscarinic receptors are involved in the increase in RT seen after 5-HT2 receptor stimulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modification of spontaneous contractility of smooth muscle preparations from the bovine abomasal antrum by serotonin receptor agonists

Spring¹,

Mevissen

Reist³

et al. 2003

Vet Pharm & Therapeutics

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“…The reported results with specific agonists and antagonists suggest that the serotonergic, adrenergic and dopaminergic control systems markedly differ in ruminants and rodents. The observed differences may be due to differences in the structure of receptors (their amino acid sequence) and the distribution of receptor subtypes (39).…”

Section: Discussionmentioning

confidence: 99%

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Jalilzadeh-Amin

Maham

Dalir‐Naghadeh

et al. 2012

Journal of Essential Oil Research

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Mentha longifolia is grown commercially for production of oils and leaves. For centuries, this plant has widely been used traditionally as a folk remedy for treatment of human and ruminant gastrointestinal complaints in the Northwest of Iran. The essential oil of the plant was extracted using hydrodistillation. In the present study a total of 12 constituents, representing 96.6% of the oil were identified by gas chromatography/mass spectrometry (GC/MS). The main compounds were 1,8-cineole (19.8%), pulegone (17.3%), caryophyllene oxide (14.8%) and isomenthone (12.4%). The effects of 0.1 to 1000 g/mL essence of Mentha longofolia (EOML) on ruminal and abomasal smooth muscle of 24 healthy sheep were assessed in vitro. In the isolated ruminal and abomasal preparations, EOML (0.1-100 g/mL) exhibited a weak spasmogenic effect followed by relaxation and complete (p < 0.05) abolition of the spontaneous contraction at the highest dose (1000 g/mL). In contrast rat ileum only showed a dose-dependent relaxation effect, and tissues preincubated with EOML decreased the acetylcholine (ACh) induced contraction. EOML (1000 g/mL) significantly inhibited the effect of ACh suggesting that the effect may be mediated via cholinergic receptors on smooth muscle. These primary data indicated that the plant contained spasmogenic and spasmolitic constituents. Moreover the results showed that the EOML profoundly alters gastrointestinal smooth muscle contraction in a dosedependent and tissue-specific manner. The results suggested that EOML has the potential for development as a prokinetic and relaxant agent that may prevent or alleviate dysfunctions of gastrointestinal motility.

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“…The oesophageal groove is a channel in the medial wall of the reticulo‐rumen of the bovine stomach. The closure of this structure allows the passage of orally administered drugs from the oesophageus directly into the abomasum, preventing the degradation or nonabsorption of certain drugs in the forestomach, and thereby achieving a higher therapeutic efficacy ( cooke & nicholson 1981 ; Van Miert et al . 1998 ) .…”

Section: Introductionmentioning

confidence: 99%

Involvement of cyclic GMP‐dependent mechanism in the nitrergic relaxation of the bovine oesophageal groove

Barahona

Sánchez-Fortún

Andrés

et al. 1999

Journal of Autonomic Pharmacology

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1. The present study was designed to investigate the mechanisms involved in the relaxations to nitric oxide (NO) of bovine oesophageal groove preparations suspended in organ baths for isometric tension recordings. In preparations treated with guanethidine (10(-5) M) and atropine (10(-7) M) to block adrenergic neurotransmission and muscarinic receptors, respectively, NO released from nitrergic nerves by electrical field stimulation (EFS, 0.5-16 Hz, 1 ms duration, 20 s trains) and exogenously applied as an acidified solution of sodium nitrite (NaNO2, 10(-6)-10(-3) M) caused frequency-and dose-dependent relaxations of noradrenaline (NA, 10(-5) M)-precontracted preparations. 2. Incubation with an inhibitor of NO-stimulated soluble guanylate cyclase, 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ, 3 x 10(-6) M, for 30 min) did not change the basal tension of oesophageal groove strips but inhibited relaxations to EFS and to exogenous NO. 3. Treatment with iberiotoxin (10(-7) M) and apamin (5 x 10(-7) M), which are blockers of large and small conductance Ca2+-activated K+ channels, respectively, did not modify basal tension or the relaxations induced by EFS and exogenous NO. Incubation with iberiotoxin (10(-7) M) or apamin (5 x 10(-7) M) plus ODQ (3 x 10(-6) M) significantly reduced the relaxations to EFS and exogenous NO. However, in both cases the reductions were similar to the inhibition caused by ODQ alone. The combined addition of charybdotoxin (3 x 10(-8) M) and apamin (5 x 10(-7) M) did not change relaxations to EFS or exogenous NO of the bovine oesophageal groove. 4. The blocker of ATP-sensitive K+ channels, glibenclamide (10(-6) M), had no effect on either resting tension or relaxations induced by both EFS and exogenous NO. Combined treatment with ODQ (3 x 10(-6) M) and glibenclamide (10(-6) M) did not produce additional inhibition compared to ODQ alone. 5. The present results indicate that NO acts as an inhibitory neurotransmitter by relaxing bovine oesophageal groove smooth muscle through a guanylate cyclase-dependent mechanism which does not appear to involve the opening of K+ channels.

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Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants

Cited by 12 publications

References 162 publications

Modification of spontaneous contractility of smooth muscle preparations from the bovine abomasal antrum by serotonin receptor agonists

Modification of spontaneous contractility of smooth muscle preparations from the bovine abomasal antrum by serotonin receptor agonists

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Involvement of cyclic GMP‐dependent mechanism in the nitrergic relaxation of the bovine oesophageal groove

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