Pharmacological and therapeutic properties of new derivatives of renin inhibitors and endothelin receptor antagonists, and the methods of their determination

Acetophenone and deoxybenzoin derivatives are selectively α‐arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di‐ and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram‐scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI‐MS spectrometry is also provided.magnified image

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Aqueous α‐Arylation of Mono‐ and Diarylethanone Enolates at Low Catalyst Loading

Astarloa

SanMartı́n

Herrero

et al. 2018

Adv Synth Catal

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Transition Metal‐Free Aroylation of Diarylmethanes with N‐Bn‐N‐Boc Arylamides and N‐Acylpyrroles

et al. 2020

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Selective transition metal-free aroylation of diarylmethanes with 2-acyl-imidazolium salts via acyl C–C bond cleavage

Dong

Gan

Yang

et al. 2020

Tetrahedron Letters

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Pharmacological and therapeutic properties of new derivatives of renin inhibitors and endothelin receptor antagonists, and the methods of their determination

Abstract: We review analytical methods used to determine new substances with hypotensive activity from two pharmacological groups: renin inhibitors and endothelin receptor antagonists.

Cited by 4 publications

References 69 publications

Aqueous α‐Arylation of Mono‐ and Diarylethanone Enolates at Low Catalyst Loading

Aqueous α‐Arylation of Mono‐ and Diarylethanone Enolates at Low Catalyst Loading

Transition Metal‐Free Aroylation of Diarylmethanes with N‐Bn‐N‐Boc Arylamides and N‐Acylpyrroles

Selective transition metal-free aroylation of diarylmethanes with 2-acyl-imidazolium salts via acyl C–C bond cleavage

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