Pharmacological and toxicological investigations of Cesium

Cesium reversibly suppresses HeLa cell proliferation by inhibiting cellular metabolism

“…Twenty-eight days after the final injection, the mice tissues were shown to have accumulated Cs during this period, in the following order: skeletal muscle > ileum > brain > liver > lung > blood. The Cs content was 11.5-144 mEqÁkg À1 wet tissue in the skeletal muscle and 10-20 mEqÁkg À1 in the blood [24]. These levels were in good agreement with the distribution of Cs-134 in the adult rat after intraperiotoneal administration [22].…”

“…Mice that were intraperitoneally injected with CsCl for 14 consecutive days prior to sarcoma implantation exhibited reduced tumor-induced mortality compared with controls [23]. The Cs content was 11.5-144 mEqÁkg À1 wet tissue in the skeletal muscle and 10-20 mEqÁkg À1 in the blood [24]. Mice that were intraperitoneally injected with CsCl for 14 consecutive days prior to sarcoma implantation exhibited reduced tumor-induced mortality compared with the controls [23].…”

Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits

“…Cs has been shown to induce the release of catecholamines. 22 The increase in the plasma norepinephrine concentration in the MVT and PVT groups might be either a cause of VT or consequence of hemodynamic changes due to ventricular tachyarrhythmias, or both.…”

“…23 Cs induces the release of catecholamines both centrally and peripherally. 22 Catecholamines potentiate all of the main electrophysiologic phenomena underlying arrhythmogenesis: increased automaticity, triggered activity due to EADs or DADs, and reentry. 25,26 However, increased catecholamine concentrations also increase heart rate, which may decrease the EAD amplitude and thereby suppress PVT.…”

Torsades de pointes - a report of a case induced by caesium taken as a complementary medicine, and the literature review

“…It suggests that caesium is safe as it is taken up only by malignant cells . This preliminary evidence is weak and insufficient to conclude a benefit . The safety of caesium is further questioned because of its known arrhythmogenic properties.…”