Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

Ye, Zhong; Zhang, Yingge; Yang, Yanlian; Sun, Lan; Han, Dong; Li, Hong; Wang, Chen

doi:10.1016/j.nano.2009.11.007

Cited by 280 publications

(146 citation statements)

References 53 publications

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“…CNTs can be functionalized with bioactive peptides, proteins, nucleic acids, and drugs, and used to deliver their cargos to cells and organs. 12 Because functionalized CNTs are not immunogenic and display low toxicity, they have great potential for use in the nanomedicine field. 13 There is reason for these materials to be further assessed, since different growth techniques result in specific physicochemical material characteristics and specific cell viability behavior.…”

mentioning

confidence: 99%

Novel nanostructured biomaterials: implications for coronary stent thrombosis

Karagkiozaki¹,

Karagiannidis²,

Kalfagiannis³

et al. 2012

IJN

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Background: Nanomedicine has the potential to revolutionize medicine and help clinicians to treat cardiovascular disease through the improvement of stents. Advanced nanomaterials and tools for monitoring cell-material interactions will aid in inhibiting stent thrombosis. Although titanium boron nitride (TiBN), titanium diboride, and carbon nanotube (CNT) thin films are emerging materials in the biomaterial field, the effect of their surface properties on platelet adhesion is relatively unexplored. Objective and methods: In this study, novel nanomaterials made of amorphous carbon, CNTs, titanium diboride, and TiBN were grown by vacuum deposition techniques to assess their role as potential stent coatings. Platelet response towards the nanostructured surfaces of the samples was analyzed in line with their physicochemical properties. As the stent skeleton is formed mainly of stainless steel, this material was used as reference material. Platelet adhesion studies were carried out by atomic force microscopy and scanning electron microscopy observations. A cell viability study was performed to assess the cytocompatibility of all thin film groups for 24 hours with a standard immortalized cell line. Results: The nanotopographic features of material surface, stoichiometry, and wetting properties were found to be significant factors in dictating platelet behavior and cell viability. The TiBN films with higher nitrogen contents were less thrombogenic compared with the biased carbon films and control. The carbon hybridization in carbon films and hydrophilicity, which were strongly dependent on the deposition process and its parameters, affected the thrombogenicity potential. The hydrophobic CNT materials with high nanoroughness exhibited less hemocompatibility in comparison with the other classes of materials. All the thin film groups exhibited good cytocompatibility, with the surface roughness and surface free energy influencing the viability of cells.

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mentioning

confidence: 99%

Novel nanostructured biomaterials: implications for coronary stent thrombosis

Karagkiozaki¹,

Karagiannidis²,

Kalfagiannis³

et al. 2012

IJN

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show abstract

“…Yang et al, [101] have recently used the administration of acetylcholine in an animal model of AD to test the efficacy of employing single-walled carbon nanotubes (SWCNTs) as drug delivery carriers to the central nervous system. These devices entered the brain via nerve axons, presented a chemical composition of more than 99% of carbon and a length of about 50-300nm.…”

Section: Single-walled Carbon Nanotubes For Acetylcholine Deliverymentioning

confidence: 99%

Brain Drug Delivery Systems for Neurodegenerative Disorders

Garbayo

Ansorena

Blanco-Prieto

2012

CPB

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Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome. There has recently been growing interest in the development of drug delivery systems (DDS) for local or systemic brain administration. DDS are able to improve the pharmacological and therapeutic properties of conventional drugs and reduce their side effects. The present review provides a concise overview of the recent advances made in the field of brain drug delivery for treating neurodegenerative disorders. Examples include polymeric micro and nanoparticles, lipidic nanoparticles, pegylated liposomes, microemulsions and nanogels that have been tested in experimental models of Parkinson's, Alzheimer's and Hungtinton's disease. Overall, the results reviewed here show that DDS have great potential for NDs treatment.

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“…2C). As mentioned above, there are two cases that the dependence of NPs on the media ChPs in their actions on their environment, one of which is the media ChPs do not leave the surface of NPs when interactions develop and the other of which is the media ChPs are released from NPs into the environment and their effects develop when these media particles diffuse to the target substances [17]. Of course, these media ChPs are dependent on electrons for their role in the interactions of NPs with each other or with their environment, but the dependence of NPs on the ChPs is direct and that on electrons is indirect after all.…”

Section: The Interactions Between Nps In the Fourth Levelmentioning

confidence: 99%

Relationship between Size and Function of Natural Substance Particles

Zhang¹

2011

Nano BioMed ENG

Self Cite

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All of the natural substances can be viewed as particles. According to the sizes of particles, the natural substances may be classified at six levels from small to large, and heir functional spectra can be established in the order from simple to complex. They are respectively point particles (?ppspPs), fundamental structural particles (FSPs), chemical particles (ChPs), nanoparticles (NPs), macroparticles (MPs) and celestial particles (CePs). The particles in one of these levels have their independent functional activities and interaction patterns different from those in the levels lower than In conclusion,the establishent of the size-function spectrum will be helpful to investigate the substance world as a whole, and reveal the interaction principles of the particles and biological essential fundamentals.Keywords: Size-function relations, Fundamental particles, Chemical particles, Nanoparticles, Macroparticles, Celestial particles Citation: Y. Zhang.Classification of substances based on use of nanoparticle as basical component.

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Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

Cited by 280 publications

References 53 publications

Novel nanostructured biomaterials: implications for coronary stent thrombosis

Novel nanostructured biomaterials: implications for coronary stent thrombosis

Brain Drug Delivery Systems for Neurodegenerative Disorders

Relationship between Size and Function of Natural Substance Particles

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