Pharmacological, antioxidant, genotoxic studies and modulation of rat splenocyte functions by Cyperus rotundus extracts

Kilani-Jaziri, Soumaya; Mhalla, Dhekra; Fadwa, Châbane; Ghedira, Zied; Limem, Ilef; Ghedira, Kamel; Chekir‐Ghedira, Leila

doi:10.1186/1472-6882-13-28

Cited by 55 publications

(28 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tested extracts were able to decrease the mouse ear oedema induced by xylene and reduced the number of abdominal contractions caused by acetic acid, revealing the peripheral analgesic activity of these extracts. No toxicity was recorded in mice treated with doses up to 300 mg/kg bw [94].…”

Section: Antiinflammatory Antipyretic and Analgesic Effectsmentioning

confidence: 93%

A review on Cyperus rotundus A potential medicinal plant

Al-Snafi¹

2016

IOSRPHR

View full text Add to dashboard Cite

Abstract:-Many previous studies showed Cyperus rotundus contained flavonoids, tannins, glycosides, furochromones, monoterpenes, sesquiterpenes, sitosterol, alkaloids saponins, terpenoids, essential oils, starch, carbohydrates, protein, separated amino acids and many other secondary metabolites. The previous works also showed that the plant exerted antiparasitic, insecticidal, repellent, antibacterial, antioxidant, anticancer, central nervous, neuroprotective, antiinflammatory, antipyretic, analgesic, hypolipidemic, weight control, antiplatelet, gastrointestinal, hepatoprotective, antidiabetic, anti-dysmenorrhea, dermatological and many other effects. This review was designed to highlight the chemical constituents and pharmacological effects of Cyperus rotundus.

show abstract

Section: Antiinflammatory Antipyretic and Analgesic Effectsmentioning

confidence: 93%

A review on Cyperus rotundus A potential medicinal plant

Al-Snafi¹

2016

IOSRPHR

View full text Add to dashboard Cite

show abstract

“…! C. rotundus is well-known for its analgesic effects [26,27]. According to a recent paper, the methanol extract of C. rotundus rhizomes significantly decreased thermally induced hyperalgesia, as assessed by a hot-plate test (52°C), in a mouse model of acute pain response, through nociceptive receptors [26,28].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Oleanolic Acid from the Rhizomes of Cyperus rotundus on Transient Receptor Potential Vanilloid 1 Channel

Nam

Lee

2014

Planta Med

View full text Add to dashboard Cite

Introduction ! Transient receptor potential vanilloid channel 1 (TRPV1), the so-called capsaicin receptor, is a nonselective cation channel with high Ca 2+ permeability [1]. TRPV1 is a well-known thermosensitive TRP channel that can sense temperatures exceeding 43°C and is also important for nociceptive signal transmission at sensory nerve endings in the peripheral nervous system [1][2][3]. Although TRPV1 has been extensively studied in nociceptive sensory neurons, such as dorsal root ganglia where it is localized in unmyelinated C fibers and small-diameter neurons, it is also widely distributed in skin cells, such as keratinocytes, mast cells, and sebocytes, which indicates that TRPV1 plays a functional role in cutaneous tissue that is not related to thermal or pain sensations [4,5]. Epidermal keratinocytes are key components of the physicochemical skin barrier. To maintain the shape and function of the epidermis, keratinocytes must achieve a balance between proliferation and apoptosis to maintain the stratum corneum, the outermost epidermal layer, which consists of dead cells that protect against noxious stimuli and excessive water loss [6]. In keratinocytes, Ca 2+ influx due to TRPV1 activation can increase intracellular Ca 2+ concentrations, which can suppress cell growth and induce apoptosis [4,7]. Interestingly, in a mouse model experiment, in which the tape stripping method was used to destroy the skin barrier, topical application of the TRPV1 activator capsaicin delayed barrier recovery, whereas application of the TRPV1 inhibitor capsazepine accelerated barrier recovery [8]. In another report, it was suggested that calcium influx through TRPV1 is critical for UVinduced matrix metalloproteinases-1 (MMP-1) expression, which can degrade skin collagen and cause deep skin wrinkle formation [9, 10]. These reports support the negative role played by TRPV1 in the recovery of skin barrier properties and photoaging. It appears that TRPV1 antagonists offer a novel therapeutic strategy for skin barrier-related diseases and the prevention of photoaging by UV radiation, and, thus, there is a demand for novel natural compounds that antagonize TRPV1.Abstract ! Cyperus rotundus is used as an analgesic and sedative in oriental medicine and has been reported to exhibit antinociceptive and anti-inflammatory effects. On the other hand, the transient receptor potential vanilloid 1 channel is a nonselective cation channel that senses various noxious chemical and thermal stimuli. However, it has recently been reported that the epidermally expressed transient receptor potential vanilloid 1 channel is involved in heat-and UV-induced skin aging. The aim of this study was to evaluate whether C. rotundus extract and its constituents can inhibit this channel. Ethylacetate and hexane fractions of the methanol extract were found to partially inhibit transient receptor potential vanilloid 1 channel activity, and at a concentration of 90 µM, oleanolic acid, which was one of three constituents isolated from the ethylacetate fraction, inhib...

show abstract

“…21 Cyperus rotundus is rich in potent components such as flavonoids, lignans, and polyphenols. [30][31][32][33] Flavonoids and lignans have estrogenic activity that may inhibit 5α-reductase and 17β-hydroxysteroid dehydrogenase via differential transcription activity of an estrogen-response element reporter. [34][35][36] Thus, hair follicles that are entirely androgen dependent can be minimized.…”

Section: Discussionmentioning

confidence: 99%