Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding Therapeutic Targets

Schrade, Katharina; Klussmann, Enno

doi:10.1007/978-3-319-54579-0_4

Cited by 2 publications

(1 citation statement)

References 155 publications

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“…Several proteins [ 46 , 47 , 48 , 49 , 50 ] contribute to cyclic nucleotide compartmentation, which spatially, temporally, and functionally controls the downstream effects of cyclic nucleotides (extensively studied for cAMP) in the cardiovascular system [ 25 , 51 , 52 , 53 ]. They include (a) GPCRs located in lipid rafts [ 54 , 55 ], at transverse tubules [ 56 ] and in non-caveolar membrane domains [ 57 ]; (b) ACs and GCs [ 58 , 59 ]; (c) Scaffold proteins [ 60 , 61 , 62 ]) such as A-kinase anchoring proteins (AKAPs) [ 52 , 63 , 64 ] and Calveolin-3 [ 54 , 65 , 66 , 67 ]; (d) physical barriers—e.g., mitochondria, cAMP buffering by PKA, cAMP export [ 68 , 69 ] are some of the mechanisms that create locally confined intracellular domains regulating signaling; and (e), the most prominent and extensively studied of all, the PDE-mediated hydrolysis of cyclic nucleotides, which is of high pharmacological and clinical interest [ 64 , 70 , 71 ].…”

Section: Compartmentation Of Camp and Cgmp Signalingmentioning

confidence: 99%

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Pavlaki

Nikolaev

2018

JCDD

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Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.

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Section: Compartmentation Of Camp and Cgmp Signalingmentioning

confidence: 99%

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Pavlaki

Nikolaev

2018

JCDD

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PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective

Oliveira

Cairrão

2021

JCDD

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Cardiovascular diseases are important causes of mortality and morbidity worldwide. Vascular smooth muscle cells (SMCs) are major components of blood vessels and are involved in physiologic and pathophysiologic conditions. In healthy vessels, vascular SMCs contribute to vasotone and regulate blood flow by cyclic nucleotide intracellular pathways. However, vascular SMCs lose their contractile phenotype under pathological conditions and alter contractility or signalling mechanisms, including cyclic nucleotide compartmentation. In the present review, we focus on compartmentalized signaling of cyclic nucleotides in vascular smooth muscle. A deeper understanding of these mechanisms clarifies the most relevant axes for the regulation of vascular tone. Furthermore, this allows the detection of possible changes associated with pathological processes, which may be of help for the discovery of novel drugs.

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Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding Therapeutic Targets

Cited by 2 publications

References 155 publications

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective

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