Pharmacological approaches to induce follicular growth and ovulation for fixed-time artificial insemination treatment regimens in ewes

Silveira, Danilo Costa da; Vargas, Sérgio Farias; Oliveira, Fernando Caetano de; Barbosa, Rafael Mielke; Knabah, Nathalia W.; Goularte, Karina Lemos; Vieira, Arnaldo Diniz; Baldassarre, Hernán; Gasperin, Bernardo Garziera; Mondadori, Rafael Gianella; Lucia, Thomaz

doi:10.1016/j.anireprosci.2021.106734

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…The results showed that both schemes make it possible to stimulate superovulation in donors ewes quite effectively. Our results are agreed with the results obtained by Bartlewski et al (2009Bartlewski et al ( , 2015 who observed a positive correlation between both of the total number of corpora lutea and total number of recovered between the superovulatory response and embryo production with FSH-P. On the contrary, our results disagreed with several researchers who reported that using FSH can effectively stimulate follicle growth, but oestrus is not observed in ewes (Duggavathi et al, 2004;Silveira et al, 2021). At the same trend, Sales et al (2011) found that FSH failed to stimulate final follicular growth, ovulation and conception rate in Nellore beef cows, these results disagree with our results.…”

Section: Ta B L Esupporting

confidence: 88%

“…In similar results, Kolling et al (2021) studied the superovulatory response and embryo production of Brazilian Bergamasca sheep using 133 mg FSH‐P, they observed a positive correlation between the superovulatory response and embryo production with FSH‐P. On the contrary, our results disagreed with several researchers who reported that using FSH can effectively stimulate follicle growth, but oestrus is not observed in ewes (Duggavathi et al, 2004; Silveira et al, 2021). At the same trend, Sales et al (2011) found that FSH failed to stimulate final follicular growth, ovulation and conception rate in Nellore beef cows, these results disagree with our results.…”

Section: Discussioncontrasting

confidence: 52%

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Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

Aybazov

Selionova

Trukhachev

et al. 2022

Reprod Domestic Animals

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The objective of this study was to investigate the response of Charolais and Ile-de-France meat sheep breeds to stimulate superovulation with various follicle-stimulating hormone (FSH) preparations. A total of 14 adult ewes of meat sheep breeds were used in our study as donors, including Charolais breed (n = 8) and Ile-de-France breed (n = 6). Donors ewes were randomly divided into two groups in equal numbers (first group, n = 7; second group, n = 7), every group included Charolais breed (n = 4) and Ile-de-France breed (n = 3). Ewes in the first group were treated with Folltropin-V (total dose of 200 mg per ewe, seven injections), and ewes in the second group were treated with FSH-P (total of 280 IU per ewe, six injections). Thirty-seven ewes of Edilbay breed used as recipients were divided into two groups (first group, n = 20; second group, n = 17). Our results showed that the number of corpora lutea in donor groups treated with Folltropin-V was significantly higher than in donor groups treated with FSH-P (p < .01). A greater number of embryos recovery and embryos suitable for transplantation were found in the first group compared with the second group of donors. After 30 days from transplantation, transabdominal ultrasonography showed that the presence of pregnancy in recipients groups was found in 16 recipient ewes (43.2%), in the first group of recipients were registered nine pregnant ewes of 20 recipient ewes (45.0%), and in the second group of recipients were registered seven pregnant ewes of 17 recipient ewes (41.2%). In conclusion, using Folltropin-V in Charolais and Ile-de-France meat sheep breeds is a more effective scheme for stimulating superovulation than using FSH-P.

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Section: Ta B L Esupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 52%

Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

Aybazov

Selionova

Trukhachev

et al. 2022

Reprod Domestic Animals

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“…Progesterone inhibits the release of LH from the anterior pituitary gland, resulting in the preventing the final development of ovarian antral follicles and ovulation (Oliveira et al., 2016). Equine chorionic gonadotropin (eCG) is usually used during and beyond the breeding season to stimulate follicular growth, and induction of ovulation in ewes (Silveira et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Timing of ovulation in the fat‐tailed Qezel ewes after synchronization with vaginal devices containing endogenous or exogenous synthetic progestogens during out of the breeding season

Hamisi,

Eslami,

Farrokhi‐Ardabili

et al. 2023

Veterinary Medicine & Sci

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BackgroundWide range of ovulation distribution is the main restricting factor in establishing the pregnancy following oestrus synchronization (ES) and fixed time insemination (FTI) in sheep.ObjectivesDetermining the ovulation time (OVT) following ES with two different vaginal devices, its relation to progesterone and conception upon FTI with frozen/thawed semen.MethodsOestrus was synchronized using either controlled internal drug release (CIDR) (ewe, n = 6; ewe lamb, n = 5) or vaginal sponge (ewe, n = 6; ewe lamb, n = 5) insertion for 12 days, plus Equine chorionic gonadotropin (eCG) at devices removal (Day 0). Sizes of the ovarian follicles were measured using transvaginal probe at −12, 0 and 30–33, 53 h and continued every 3–4 h until 75 h after eCG treatment. Serum progesterone amounts were measured at −12, 0, +2 and +11. Laparoscopic FTI was done at 60.5 ± 0.5 h.ResultsThe CIDR‐treated group initiated and completed ovulations earlier compared to sponge‐treated females (median: 64 vs. 71 h; p < 0.05). Ewe lambs were ovulated earlier compared to ewes in the sponge‐treated group (66.71 vs. 71.5; p = 0.017). Mean sizes of ovulatory follicles and corpora lutea were not affected by device types. Higher amounts of progesterone were observed in CIDR group compared to sponge‐treated group at device removal (2.68 ± 0.12 vs. 0.30 ± 0.01 ng/mL; p < 0.001). The conception was confirmed in 2/10, and 5/11 females of sponge and CIDR‐treated females, respectively.ConclusionsTypes of progestogens influence the OVT, and consequently the result of FTI with frozen/thawed semen. The optimum timespan for FTI should be chosen according to the device types during non‐breeding season.

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The Utilization of a Pregnancy-Associated Glycoprotein Profile and PAG/P4 Ratio Biomarker for the Diagnosis of Pseudopregnancy in Dairy Goats

Cruz,

Margatho,

Simões

et al. 2024

Veterinary Sciences

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Pseudopregnancy (PPG) is a common reproductive disorder in dairy goats, characterized by the accumulation of sterile fluid in the uterus and persistence of a corpus luteum, leading to temporary infertility and reduced farm efficiency. This study aimed to determine the pregnancy-associated glycoprotein (PAG) profile in dairy goats and to evaluate the PAG/P4 ratio as a potential novel biomarker for PPG diagnosis. A total of 605 Saanen and crossbreed mated goats were evaluated via transabdominal ultrasonography between 31 and 52 days after the removal of bucks in four intensive dairy farms, presenting an overall PPG incidence of 7.8%. Blood samples from PPG (n = 47), nonpregnant (NPG; negative control; n = 11), and pregnant (PG; positive control; n = 10) does were collected for PAG and P4 analysis. The PAG plasma levels were 0.08 ± 0.02, 0.13 ± 0.04, and 1.45 ± 0.04 OD (optical density) in the PPG, NPG, and PG groups, respectively (p < 0.001). The PAG/P4 ratio was lower in the PPG group (0.01 ± 0.11; p < 0.001) than in the NPG (0.24 ± 0.23) and PG (0.18 ± 0.23) groups. This difference allows for the establishment of a new methodological diagnostic approach to PPG. The area under the curve (AUC) was 0.996 for a cut-off of 0.04 and 97.9% and 100% sensitivity and specificity, respectively. This study suggests that the PAG/P4 ratio can serve as a reliable biomarker for PPG diagnosis, helping to distinguish it from pregnancy and nonpregnancy and improving reproductive management in dairy goats.

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Pharmacological approaches to induce follicular growth and ovulation for fixed-time artificial insemination treatment regimens in ewes

Cited by 3 publications

References 30 publications

Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

Timing of ovulation in the fat‐tailed Qezel ewes after synchronization with vaginal devices containing endogenous or exogenous synthetic progestogens during out of the breeding season

The Utilization of a Pregnancy-Associated Glycoprotein Profile and PAG/P4 Ratio Biomarker for the Diagnosis of Pseudopregnancy in Dairy Goats

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