Pharmacological aspects of juglone

Auyong, Theodore K.; Westfall, B. A.; Russell, Robert L.

doi:10.1016/0041-0101(63)90005-9

Cited by 22 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was not until the 1850s that juglone (then termed “nucin” from the Latin nux , meaning a nut) was first isolated from the walnut tree [22], and in 1881 the first scientific report on the allelopathic effect of juglone was published [23]. Further, juglone has been found to have various pharmacological actions, including a depressant effect [24], an impact on skin diseases [16], and antimicrobial [25], anti-cancer [26,27,28], anti-fungal [25], and antioxidant [29] activities, as well as apoptotic capacities [30] and anti-angiogenesis properties [31]. Juglone and its derivatives have been shown to possess the ability to inhibit food degradation by creating resistance to oxygen and its reactive species [29].…”

Section: Introductionmentioning

confidence: 99%

Juglone in Oxidative Stress and Cell Signaling

2019

View full text Add to dashboard Cite

Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and aging processes. However, being a quinone molecule, juglone could also act as a redox cycling agent and produce reactive oxygen species. Such prooxidant properties of juglone may confer health effects, such as by killing cancer cells. Further, recent studies revealed that juglone influences cell signaling. Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer’s disease. Juglone also activates mitogen-activated protein kinases that could promote cell survival, thereby protecting against conditions such as cardiac injury. This review describes recent advances in the understanding of the effects and roles of juglone in oxidative stress and cell signaling.

show abstract

Section: Introductionmentioning

confidence: 99%

Juglone in Oxidative Stress and Cell Signaling

2019

View full text Add to dashboard Cite

show abstract

“…Juglone has toxic and antitumor activities resulting from cell membrane damage and oxidative stress induction [93]. Juglone can inhibit the proliferation of tumor cells by apoptosis induction.…”

Section: Biological Activitymentioning

confidence: 99%

Phytochemistry, Bioactivity and Potential Impact on Health of Juglans: the Original Plant of Walnut

Zhao

Jiang

et al. 2016

Natural Product Communications

View full text Add to dashboard Cite

Walnuts can nourish brain cells to improve human memory. Other parts of the plant are also employed as traditional Chinese medicines. Modern research on Juglans species has been mostly focused on the above-mentioned species, the seeds of which are all called walnuts. Juglans species have diverse chemical constituents, including diarylheptanoids, quinones, polyphenols, flavones and terpenes. The diarylheptanoids and quinones have notable antitumor activity, supplying new lead compounds for preparing antitumor drugs. The potent pain-relieving, antioxidant, antibacterial and antitumor activities of these plants are significant. In the review, comprehensive information on the nutritional characteristics, traditional functions, chemical constituents, and biological activities of the Juglans species, together with the seeds used as walnuts is provided to explore their potential and to advance research.

show abstract

“…Usually the application of juglon is made as a direct dye,;thus no mordants or other fixatives are required. Juglon is a quite bioactive molecule which is widely used in pharmaceutical applications, but is also known to cause skin irritation and toxic effects [34][35][36].…”

Section: Juglon CI Natural Brownmentioning

confidence: 99%

Natural Colorants in Hair Dyeing

Bechtold

2009

Handbook of Natural Colorants

View full text Add to dashboard Cite

The desire to influence the individual appearance is as old as mankind itself. Thus coloration of hair and skin is found almost everywhere and numerous cultural expressions of such a habit have been reported.In today's modern societies a considerable share of women and men apply colorants to change the colour of their hair; for example, 75 % of all American women are estimated to dye their hair [1]. In Europe more than 60 % of women and 5-10 % of men colour their hair, with a mean frequency of 6-8 times per year. The market for hair dyes in the EU has been estimated in 2004 at E2.6 billion [2]. Examples for relevant motivations for hair coloration are: -demonstration of individuality by hair colour; -fashion trends and cosmetic aspects; -desire to cover white hair to maintain a youthful appearance.Cosmetologists distinguish hair colorants with regard to the achieved permanence of the dyeing between temporary hair dyes, semi-permanent or permanent hair dyes, which will depend both on the type of dyestuff used and the conditions applied. The main difference is in the number of shampoos the dyeing will last, which ranges from 6 to 12 for semi-permanent colours to permanent dyeings which cannot be washed out.While some traditional coloration of skin and hair is based on the application of pigments from, for example, clay or carbon, the focus of this chapter will be directed on the application of natural dyes to human hair. The colorants will be sorted with regard to their chemical nature and source. Handbook of Natural Colorants Edited

show abstract

Pharmacological aspects of juglone

Cited by 22 publications

References 2 publications

Juglone in Oxidative Stress and Cell Signaling

Juglone in Oxidative Stress and Cell Signaling

Phytochemistry, Bioactivity and Potential Impact on Health of Juglans: the Original Plant of Walnut

Natural Colorants in Hair Dyeing

Contact Info

Product

Resources

About