Pharmacological Aspects of Psidium guajava: An Update

Sanda, Kyari Abba; Grema, H.A.; Geidam, Yaqub Ahmed; Bukar-Kolo, Y.M.

doi:10.3923/ijp.2011.316.324

Cited by 149 publications

(48 citation statements)

References 13 publications

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“…The phytochemical compounds detected in the ethanol leaf extract of Psidium guajava L. in this present study do agree with the report of several related studies 8,[14][15][16][17] in which similar phytochemicals were detected. However, saponin detected by Shruthi et al 14 and Cho et al 18 was not detected in this present study.…”

Section: Discussionsupporting

confidence: 83%

“…In Nigeria, south Africa, Ghana and Kenya, Panama, Cuba, Costa Rica, Mexico, Nicaragua, Venezuela Mozambique, Guatemala and Argentina, guava is used traditionally for treatment of various ailments like, diarrhoea, wounds, rheumatism, lung problem, ulcer, malaria, cough, fever, inflammatory conditions, as well as diabetes mellitus 7 . It has also been reported to contain a number of phytochemicals and pharmacological active principles such as flavonoids, guayolic acid, guavanoic acid, guajadial and guajarin 8 .…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

Wazis¹,

Sy²,

HB³

et al. 2016

J. Pharm. Sci. Innov.

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Psidium guajava is an important food crop and medicinal plant available in tropical countries, widely used in food and folk medicines around the world. The aim of this study is to investigate the analgesic property of ethanol leaf extract of Psidium guajava. The Psidium guajava L. leaves were freshly collected from cultivated source on the in December 2014 at the Agricultural Science Farm of University of Maiduguri. This was dried, powdered and macerated with 95% ethanol to give the ethanol extract. The extract was then used to evaluate the preliminary phytochemistry and analgesic property. The preliminary phytochemical screening revealed the presence of alkaloids, steroids and triterpenoids, carbohydrate, cardiac glycosides, tannins and flavonoids. The leaf extract of Psidium guajava exhibited significant analgesic effect in acetic acid and tail immersion induced pain at the dose of 250 to 1000 mg/kg in rats. The ethanol leaf extract of Psidium guajava contain some active phytochemical constituents which may be responsible for the observed analgesic activity and this amply justify the traditional use of this plant as a pain reliever.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

Wazis¹,

Sy²,

HB³

et al. 2016

J. Pharm. Sci. Innov.

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show abstract

“…The reduction of blood pressure in normotensive guinea pigs was might be due to different phytochemical compounds. Similarly study done by [8,32] phytochemicals such as lycopene and quercetin have potential to induce vasodilation by stimulating production of nitric oxide that can cause relaxation of smooth blood vessels. Another study also described that on aqueous leaf extract of Anona muricata showed that there was decreased blood pressure in normotensive Sprague Dawley rats [17].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of P. guava may be due to the presence of many different phytochemical compounds such as vitamin C, vitamin A, iron, calcium, manganese, phosphoric, oxalic and malic acids, saponin combined with oleanolic and others. Lycopene, quercetin, α-pinene, β-pinene, limonene, menthol are compounds from its polyphenols, resin, gallic acid, tannin, phenolics, and flavonoids are found in different parts of this medicinal plants [8,32]. Mainly this study was designed to examine the effect of an ethanol P. guava leaf extract on blood pressure in normotensive guinea pigs.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ethanol <i>Psidium guava</i> Leaf Extract on Blood Pressure in Normotensive Guinea Pigs

Elias¹

2017

AJBLS

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Non-communicable diseases are severe world health problems mainly in sab Saharan-African countries developing countries including Ethiopia. Cardiovascular diseases are one of the major non-communicable diseases increase with rises of hypertension. Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. A billion people affected globally and millions of them deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used for treatments hypertension. Psidium guava is one popular medicinal plant which is widely used in traditional medicine treatment of different diseases such as diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify the effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on eight male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive methods. The result was analyzed by using independent student t test and one way ANOVA. Ethanol extract of P. guava leaf showed a significant (p=0.05, p=0.001) reduction of blood pressure of in normotensive guinea pigs in dose dependent manner. The effect of P. guava leaf extract in reduction of blood pressure is may be due to a number of phytochemical contents.

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“…Another study also suggested that P. guava may have strong anti-oxidant properties [30], [40]. Hepato-protective and anti-cancer effects have also been suggested in non-human studies [17], [25], [28], [31]. However, some studies showed negative effects of P. guava on spermatogenesis in rats [7].…”

Section: Introductionmentioning

confidence: 99%

The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

Elias¹

2017

JDMP

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Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one -way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.

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Pharmacological Aspects of Psidium guajava: An Update

Cited by 149 publications

References 13 publications

Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

The Effect of Ethanol <i>Psidium guava</i> Leaf Extract on Blood Pressure in Normotensive Guinea Pigs

The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

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Pharmacological Aspects of Psidium guajava: An Update

Cited by 149 publications

References 13 publications

Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

Phytochemical Screening and Analgesic Effect of Ethanol Leaf Extract of Psidium Guajava (Linn)

The Effect of Ethanol &lt;i&gt;Psidium guava&lt;/i&gt; Leaf Extract on Blood Pressure in Normotensive Guinea Pigs

The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

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The Effect of Ethanol <i>Psidium guava</i> Leaf Extract on Blood Pressure in Normotensive Guinea Pigs