Pharmacological aspects of schiff base metal complexes: A critical review

Ashraf, Tuba; Ali, Bakhat; Qayyum, Hasnain; Haroone, Muhammad Sohail; Shabbir, Ghulam

doi:10.1016/j.inoche.2023.110449

Cited by 42 publications

(17 citation statements)

References 104 publications

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“…In addition, numerous investigations have reported that heterocyclic rings containing sulphur, nitrogen, and/or oxygen are responsible for the biological activity of Schiff bases and their metal complexes. Furthermore, it has been confirmed that chelation in these compounds, to a large extent, is also responsible for such activity [136,137].…”

Section: Copper Complexes With Bidentate Benzothiazole Ligandsmentioning

confidence: 88%

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

et al. 2023

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Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.

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Section: Copper Complexes With Bidentate Benzothiazole Ligandsmentioning

confidence: 88%

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

et al. 2023

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“…The spectral data of the synthetic thiourea Schiff base ligands such as +IDA-TOF-MS, 1 H-NMR, 13 C-NMR and FTIR were determined. 7.47 (d, J = 2.0, 1H, Sal), 7.38 (dd, J = 7.5; 2.5, 1H-Sal), 7.36 (dd, J = 7.5; 1.0, 2H-Ph), 7.24 (t, J = 7.0, 2H-Ph), 7.07 (t, J = 6.5, 1H-Ph), 6.83 (d, J = 7.0, 1H, Sal), 3.80 (s, 4H, Et), 1.27 (s, 9H, t-Bu);…”

Section: Synthesis Of Schiff Base Thiourea Ligandsmentioning

confidence: 99%

“…They can act as catalysts in transformations of organic synthesis 5,6 . They may exhibit excellent bioactive capabilities such as antimicrobial, antioxidant, DNA/BSA binding, anticancer, and biosensor activities 7–15 . Photophysical, electronic and magnetic properties of Schiff base metal complexes are deeply interested in a great number of researchers in material science 16–20 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization and bioactivities of iron(III) and copper(II) complexes containing Schiff base thiourea ligands of 5‐(tert‐butyl)‐2‐hydroxybenzaldehyde

Trung,

Nam,

Van Tuyen

2024

Vietnam Journal of Chemistry

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Azomethine and thiourea groups possess potential bioactive functions in pharmacological substances so organic ligands containing both imine and thiourea groups and their metal complexes will be expected to have remarkable bioactivities. In this study, some iron(III) and copper(II) complexes containing Schiff base thiourea ligands derived from 1‐(2‐aminoethyl)‐3‐phenylthiourea or 1‐(2‐aminophenyl)‐3‐phenylthiourea and 5‐(tert‐butyl)‐2‐hydroxybenzaldehyde were synthesized and characterized by modern physicochemical analysis approaches such as mass, infrared, UV–vis spectra and effective magnetic moments. The analytical data have supported for the structures of iron(III) complexes in the molecular ratio of 1:2 of iron(III) and the relative ligand while copper(II) complexes in the ratio of 1:1. The synthetic ligands coordinated with iron(III) as NO bidentate mode, however they chelated with copper(II) as NNOS tetradentate possibly. The obtained iron(III) complexes possess high‐spin octahedral geometry when copper(II) complexes perform distorted square planar. The obtained metal complexes were investigated in their thermal stability and chemical components by the thermogravimetric analysis. The synthetic Schiff base thiourea ligands were examined for their antimicrobial activity. Additionally, the synthesized complexes were estimated for their in vitro anticancer property against human cancer cell lines, hepatic cancer cells (HepG‐2), and lung adenocarcinoma cells (A549).

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“…Schiff bases can be easily synthesized by a condensation reaction of different amino substituted compounds with versatile aldehydes or ketones [7]. Besides the fact that Schiff bases are important building blocks in medicinal chemistry due to their broad spectrum of biological activity [8][9][10][11][12], they have also been used in coordination chemistry [13][14][15], in analytical chemistry [16], as dyes [17], as optical chemosensors [18][19][20], as polymers [21], in catalysis [22], in metallurgy and refining of metals, and as fungicidal and agrochemical compounds. Additionally, the interest of numerous scientists is focused on evaluating Schiff bases as ligands for transition metals displaying diverse biological activities, such as anticancer [23,24], antimicrobial [25,26], and antifungal activities [27].…”

Section: Introductionmentioning

confidence: 99%

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

et al. 2023

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Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity. The impact on the biological activity of substituents placed at the N atom of the benzimidazole nuclei and the type of substituents attached at the phenyl ring were examined. All of the synthesized Schiff bases were evaluated in vitro for their antiviral activity against different viruses, antibacterial activity against a panel of bacterial strains, and antiproliferative activity on several human cancer cell lines, thus enabling the study of the structure−activity relationships. Some mild antiviral effects were noted, although at higher concentrations in comparison with the included reference drugs. Additionally, some derivatives showed a moderate antibacterial activity, with precursor 23 being broadly active against most of the tested bacterial strains. Lastly, Schiff base 40, a 4-N,N-diethylamino-2-hydroxy-substituted derivative bearing a phenyl ring at the N atom on the benzimidazole nuclei, displayed a strong antiproliferative activity against several cancer cell lines (IC50 1.1–4.4 μM). The strongest antitumoral effect was observed towards acute myeloid leukemia (HL-60).

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Pharmacological aspects of schiff base metal complexes: A critical review

Cited by 42 publications

References 104 publications

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

Synthesis, structural characterization and bioactivities of iron(III) and copper(II) complexes containing Schiff base thiourea ligands of 5‐(tert‐butyl)‐2‐hydroxybenzaldehyde

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

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