Pharmacological basis for sedative and hypnotic like effects of <i>Pyrus pashia</i> using in vivo experimental models

Ain, Quratul; Khan, Haroon

doi:10.1002/gps.5059

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…a sedative-hypnotic effect at the concentration of ≥400 mg/kg body weight, although cytotoxicity was observed only at the concentration of 1,500 mg/kg body weight (51). The outcome of that study may lead to the development of treatment strategies for conditions such as insomnia, providing a scientific rationale for its ethnomedicinal use.…”

Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 84%

“…Cytotoxicity and toxicological studies. The study of the acute toxicity of hydroethanolic extracts tested at doses of 200 and 400 mg/kg has revealed no cytotoxicity up to 72 h and has been found to be safe up to 1 g/kg body weight in female albino mice (51). The extract has been shown to exert Table III The active concentration values are presented as the mean ± SD.…”

Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 99%

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Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

2021

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The consumption of wild edible fruits for nutritional and medicinal benefits has been known for a long time. These naturally occurring fruit plants can thrive well under adverse climatic conditions and are being harvested and marketed locally. Pyrus pashia (P. pashia; Buch.-Ham. ex D. Don; family, Rosaceae), commonly known as 'wild edible or Himalayan pear' is one of such underutilized trees. It is widely distributed in temperate regions up to an altitude of 2,000 m in Western Himalaya. It has broad applications in traditional therapeutics for the treatment of diseases, such as eye infections, sore throat, diarrhea, stomach disorders and other infectious diseases. Chlorogenic acid, flavan-3-ols, gallic acid, tannins, alkaloids, hydroquinone, terpenoids and its isomers have been isolated and identified from the leaf, fruit, flower and bark portion of P. pashia. The phytochemicals present in the P. pashia tree may be responsible for the traditional beneficial health effects of the plant. Numerous scientific studies on P. pashia have validated the general uses of the plant by the native population; however, the data on its pharmacological properties and the mechanisms involved are insufficient. The present review aimed to provide a critical evaluation of the distribution, traditional uses, phytochemicals present, pharmacological activities and nutritional value of different plant parts of P. pashia. Detailed research is required on individual phytochemicals present and toxicological studies at the gene level. In-depth molecular studies may also confirm the various pharmaceutical claims for the development of novel pharmaceutical drugs and functional food products. Contents1. Introduction 2. Habitat and morphology 3. Traditional uses of various parts of P. pashia 4. Nutritive value 5. Phytochemistry and pharmacological properties 6. conclusion and future perspectives

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Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 84%

Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 99%

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

2021

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“…Substances that depress the CNS, in general, increase the duration of sleep produced by pentobarbital, and there may also be a reduction in the latency for the effect of the barbiturate used, seen by the reduction in the induction time, that is, from the application of the barbiturate until the loss of the postural reflex by the animal [ 52 ]. Our results showed that HEPC effectively decreased sleep latency and increased the total sleep time of animals submitted to the barbiturate-induced sleep test.…”

Section: Discussionmentioning

confidence: 99%

Neuropharmacology Potential of the Hydroalcoholic Extract from the Leaves of Piper cernuum: Anxiolytic, Hypnotic, and Antidepressant‐Like Effects

Maia

Jurcevic

Malheiros

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Aim. The use of medicinal plants in the treatment of mental illnesses is a reality that accompanies the history of civilizations, and the Piper genus exhibits many species with pharmacologically proven central effects. Then, this study evaluated the neuropharmacological effects of the hydroalcoholic extract from Piper cernuum (HEPC) leaves to validate its uses in folk medicine. Materials and Methods. Primarily Swiss mice (female, 25–30 g) were pretreated with HEPC (50–150 mg/kg, p.o.), vehicle, or the positive control, and submitted to open-field test (OFT), inhibitory avoidance test (IAT), tail suspension test (TST), and forced swim test (FST). Also, mice were exposed to pentylenetetrazol- and strychnine-induced seizure assay, pentobarbital-induced hypnosis test, and elevated plus-maze (EPM). The GABA levels and MAO-A activity were measured in the animal’s brain after 15 days of HEPC administration (150 mg/kg, p.o.). Results. Mice pretreated with HEPC (100 and 150 mg/kg) and exposed to pentobarbital presented decreased sleep latency and increased sleep duration (HEPC 150 mg/kg). In EPM, the HEPC (150 mg/kg) increased the frequency of entry and the time of exploration of mice in the open arms. The antidepressant-like properties of HEPC were demonstrated by the decrease in the mice’s immobility time when tested in FST and TST. The extract did not show anticonvulsant activity, in addition to not improving the memory parameters of animals (IAT) or interfering with their locomotor activity (OFT). Besides, HEPC administration decreased the MAO-A activity and increased the GABA levels in the animal’s brain. Conclusion. HEPC induces sedative-hypnotic, anxiolytic-, and antidepressant-like effects. These neuropharmacological effects of HEPC could be, at least in part, related to the modulation of the GABAergic system and/or MAO-A activity.

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“…We evaluated the sedative effects of catechin as well as cetirizine at the doses used in the current study by their effect on the barbiturate-induced sleeping time in mice. This method is widely employed for CNS safety pharmacological studies [ 43 , 44 ]. The results illustrated no change in the barbiturate-induced sleeping time in treated rats compared to the vehicle-treated animals.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of a Neoteric Regimen of Catechin plus Cetirizine on Ovalbumin-Induced Allergic Rhinitis in Rats

Morsy

Patel

Bakrania

et al. 2022

Life

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Allergic rhinitis (AR) affects 20–50% of the global population. Available treatments are limited by their adverse effects. We investigated the anti-allergic effects of catechin alone and combined with cetirizine against ovalbumin-induced AR. Rats were sensitized with ovalbumin and received catechin (14 days) and then challenged with aerosolized ovalbumin (1%) to determine AR clinical scores. Histamine, histamine release, and histidine decarboxylase (HDC) activity were determined in blood, peritoneal mast cells, and stomachs, respectively. Vascular permeability and safety were assessed using Evans blue leakage and barbiturate-induced sleeping-time assays, respectively. Catechin and cetirizine binding with HDC was investigated by docking and binding energy analyses. The clinical scores of the combination regimen were superior to either drug alone. All treatments reduced vascular leakage, with no effect on barbiturate-induced sleeping time. Only the catechin-treated rats showed reduced histamine levels and HDC activity. Docking studies revealed that catechin has a 1.34-fold higher extra-precision docking score than L-histidine. The binding energy scores for catechin-HDC, L-histidine-HDC, and histamine-HDC were −50.86, −37.64, and −32.27 kcal/mol, respectively. The binding pattern of catechin was comparable to the standard HDC inhibitor, histidine methyl ester, but with higher binding free energy. Catechin binds the catalytic residue S354, unlike cetirizine. The anti-allergic effects of catechin can be explained by HDC inhibition and possible antihistaminic activity.

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Pharmacological basis for sedative and hypnotic like effects of Pyrus pashia using in vivo experimental models

Cited by 8 publications

References 35 publications

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

Neuropharmacology Potential of the Hydroalcoholic Extract from the Leaves of Piper cernuum: Anxiolytic, Hypnotic, and Antidepressant‐Like Effects

Ameliorative Effect of a Neoteric Regimen of Catechin plus Cetirizine on Ovalbumin-Induced Allergic Rhinitis in Rats

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