Pharmacological basis for the folkloric uses of &lt;i&gt;Buxus wallichiana&lt;/i&gt; in gastrointestinal, respiratory and vascular disorders

Hussain, Musaddique; Raza, Shahid Masood; Janbaz, Khalid Hussain

doi:10.3329/bjp.v10i2.22285

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…This study has demonstrated that B. sempervirens possesses antispasmodic and prokinetic activities. Similar results were obtained in studies on Buxus wallichiana (a plant in the same genus) which is used for treating gastrointestinal, cardiovascular and respiratory illnesses [15].…”

Section: Discussionsupporting

confidence: 71%

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Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of Buxus sempervirens Linn (Buxaceae)

Hamid¹,

Janbaz²

2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 71%

“…The traditional use of B. sempervirens as a laxative and spasmolytic [2,15] formed the bases of this study. Results from phtochemical analysis showed that AqMeBS contains flavonoids, tannins, alkaloids and saponins.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of Buxus sempervirens Linn (Buxaceae)

Hamid¹,

Janbaz²

2017

Trop. J. Pharm Res

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“…Other plants traditionally used for asthma such as Viola odorata and Buxus wallichiana (Hussain et al, 2015) act by blocking Ca 2+ channel.…”

Section: Concentration Of Extractmentioning

confidence: 99%

Bronchodilatory effect of Myxopyrum serratulum in animal model

Maruthamuthu

Kandasamy

2017

Bangladesh J Pharmacol

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Research ArticleBronchodilatory effect of Bronchodilatory effect of Bronchodilatory effect of Myxopy-MyxopyMyxopyrum serratulum rum serratulum rum serratulum in animal model in animal model in animal model BJP IntroductionBronchial asthma is a chronic inflammatory disease of the airway. Infiltration of various inflammatory cells such as eosinophil, macrophages and lymphocytes into the airway causes asthma and bronchitis (Patel et al., 2013).Bronchodilator drugs works by rapid reversal of the airway obstruction in asthmatics by directly acting on airway smooth muscle (Church and Hiroi, 1987). Drugs derived from natural sources are generally considered no adverse effects when compared to synthetic drugs, therefore, it might serve as better alternative for many chronic diseases such as cancer, infections and endemic diseases like asthma, bronchitis and many others (WHO, 2000). Plant extract and secondary metabolites derived from plant can directly influence the production and activation of inflammatory mediators, seconddary messengers and the expression of transcription factors (Calixto et al., 2004).Myxopyrum serratulum belongs to large shrub mainly found in Kerala at a altitude of about 600-900 m. It is commonly known as chaturamulla and traditionally, dried and powdered leaves of the plant was mixed with ghee as a remedy for asthma, cough and nerves complaints apart from which they were also used for the treatment of fever, headache and ear diseases (Wealth of India, 2011).According to earlier reports, the plant possesses antiinflammatory, antiarthritic ), antioxidant (Sheelarani et al., 2013), antipyretic (Vanughese et al., 2015, wound healing (Gopalakrishnan and Rajameena, 2013) and antimicrobial (Gopalakrishnan et al., 2012) properties.The phytochemical studies on M. serratulum revealed AbstractThe plant Myxopyrum serratulum is traditionally claimed to relieve asthma and cough. The present study was undertaken to evaluate the bronchodilatory effect of the methanolic extract of M. serratulum on histamine-induced bronchospasm by in vivo and the inhibitory effect of the extract on histaminecontracted tracheal chain and ileum by in vitro guinea pig model. Additionally, the relaxant effect of four cumulative concentrations of the extract (0.25, 0.5, 0.7 and 1.0 g%) was assessed using precontracted tracheal chain under different conditions. The extract (400 mg/kg) prolonged the preconvulsive time to 102.3 ± 3.8 sec when compared to saline and standard chlorpheniramine maleate as 121.3 ± 4.5 sec (p<0.05). The extract also possessed significant inhibitory effect on histamine-contracted guinea pig ileum and tracheal chain and also exhibited significant relaxation effect on precontracted tracheal chain of guinea pig models contracted by 60 mM KCl (p<0.001) and 10 µM methacholine (p<0.001) when compared with standard theophylline. Article Info

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“…For the assessment of calcium channel blockade, jejunum preparations were depolarized by exposing to high K + (80 mM), resulting in sustained contraction (Arshad et al, 2012;Hussain et al, 2015c). Ethanolic extract was applied in a cumulative manner to the sustained contractions to achieve concentration-dependent inhibitory response (Farre et al, 1991).…”

Section: Assessment and Conformation Of Ca 2+ Channel Blocking Activitymentioning

confidence: 99%

Folkloric uses of Jatropha gossypifolia in emesis and gut motility disorders: Pharmacological validation

Hussain

Raza

Majeed

2015

Bangladesh J Pharmacol

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Jatropha gossypifolia is used in folkloric system to manage emesis and gastrointestinal motility disorders such as constipation and diarrhea. The present study was undertaken to provide pharmacological evidences for these folkloric uses by in vivo and in vitro experimental setting. Ethanolic extract of J. gossypifolia showed the significant antiemetic potential (p<0.05) against different emetogenic stimuli, when compared with chlorpromazine. The extract (0.01-1.0 mg/mL) on application to isolated rabbit jejunum preparation exerted spasmogenic effect, followed by the spasmolytic effect (3-10 mg/mL). In the presence of atropine, spasmogenic effect was blocked while spasmolytic effect was emerged, suggesting the involvement of muscarinic receptor activation. J. gossypifolia caused relaxation of high K+ (80 mM)-induced contraction and shifted the Ca2+ concentration-response curve to the right in a manner similar to verapamil, thus conforming its Ca2+-channel blocking activity. These findings provide pharmacological validation for the presence of antiemetic and gut modulator (spasmogenic and spasmolytic) activates, validating its folkloric uses.

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Pharmacological basis for the folkloric uses of <i>Buxus wallichiana</i> in gastrointestinal, respiratory and vascular disorders

Cited by 5 publications

References 18 publications

Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of <i>Buxus sempervirens</i> Linn (Buxaceae)

Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of <i>Buxus sempervirens</i> Linn (Buxaceae)

Bronchodilatory effect of <i>Myxopyrum serratulum</i> in animal model

Folkloric uses of <i>Jatropha gossypifolia</i> in emesis and gut motility disorders: Pharmacological validation

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