Pharmacological Characteristics of Ryokan-kyomi-shinge-nin-to, an Antiallergic Kampo Medicine.

Sakaguchi, Masaru; Ikeda, Yoshiki; Kido, Toshitaka; Yuzurihara, Mitsutoshi; Kase, Yoshio; Yamamoto, Masahiro; Ishige, Atsushi; Sasaki, Hiroshi

doi:10.1248/bpb.25.1562

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Allergic rhinitis is characterized by overproduction of Th2 cytokines, which initiate and sustain allergic asthmatic inflammatory responses by enhancing the production of IgE and the growth (6) , differentiation and recruitment of mast cells, basophils and eosinophils. Recently, it has been reported that treatment with various traditional medicines had a beneficial effect for patients with allergic rhinitis (41)(42)(43) . More recently, Mita reported that Bu-zhong-yi-qi-tang up-regulated TLR4 expression on macrophages (16) .…”

Section: Discussionmentioning

confidence: 99%

Japanese traditional medicine, Senn-kinn-naidaku-sann up-regulates Toll-like receptor 4 and reduces murine allergic rhinitis

Morikura¹,

Murata²,

Aoi³

et al. 2014

Rhin

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Objective: To determine the mechanisms by which a traditional herbal medicine, Senkinnaidakusan (SKNS), controls Th2 responses, we examined the production of IL-12 by murine macrophages treated with SKNS. Results: Treatment with SKNS significantly increased TLR4 mRNA in macrophages. Furthermore, pre-treatment with SKNS enhanced the production of IL-12 by macrophages stimulated with LPS. When SKNS was orally administered to C3H/HeN mice at the induction phase after OVA sensitization, the serum levels of OVA-specific immunoglobulin (Ig)E and IgG1 decreased, Interleukin (IL)-4 production by spleen T cells in response to OVA was significantly suppressed, while interferon (IFN)-gamma production was increased. After nasal challenge of OVA, eosinophilic infiltration in the nasal mucosa and the number of sneezes were significantly inhibited in SKNS-treated mice compared with control mice. Besides, expression of IL-5 in the nasal mucosa was also inhibited. Using another strain of mice, C3H/HeJ (TLR4 negative), there was no difference in OVA-specific Igs or splenic cytokine production between the SKNS treatment and non-treatment groups. The eosinophilic infiltration in the nasal mucosa, the number of sneezes and IL-5 expression in the nasal mucosa were also not effected even after SKNS treatment. Conclusion: These results suggest that oral administration of SKNS inhibits Th2 responses by enhancement of IL-12 release from macrophages via up-regulation of TLR4 expression.

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Section: Discussionmentioning

confidence: 99%

Japanese traditional medicine, Senn-kinn-naidaku-sann up-regulates Toll-like receptor 4 and reduces murine allergic rhinitis

Morikura¹,

Murata²,

Aoi³

et al. 2014

Rhin

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“…In an experimental study, RKS was shown to decrease sneezing and inhibit vascular permeability induced by histamine or serotonin, although it did not affect histamine release [67]. …”

Section: Discussionmentioning

confidence: 99%

Complementary Therapies in Allergic Rhinitis

et al. 2013

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Objective. To determine the prevalence of herbal treatment of allergic rhinitis. Methods. In this prospective study, patients who were diagnosed with perennial allergic rhinitis were questioned about their use of natural products/herbal therapies for their symptoms. Results. In total, 230 patients were enrolled. Overall, 37.3% of the patients stated that they had used natural products/herbal therapies at least once. Women were more likely than men to use herbal supplements (38.3% versus 32.4%). Ten different types of herbal supplements were identified, with stinging nettle (Urtica dioicath), black elderberry (Sambucus nigra), and Spirulina being the most common (12.6%, 6.1%, and 5.7%, resp.). Conclusion. This study found a high prevalence of herbal treatment usage for the relief of allergic rhinitis symptoms in Turkey. The herbal products identified in this study and in the literature are discussed.

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“…However, the most of crude drug constituents except for GF significantly contributed to the anti-allergic activity of SSHT, and we could not find the main active ingredients of shin'iseihaito. In another limitation, although there are many studies about the suppressing effects of Kampo prescriptions such as gyokuheifusan, bakumijiogan, ryokankyomishingeninto, and shoseiryuto on allergic mice, we did not compare the effects of SSHT with these prescriptions and could not show the benefit of shin'iseihaito [35][36][37][38]. In addition, it is necessary to confirm the anti-allergic activities of SSHT in clinical studies.…”

mentioning

confidence: 95%

Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines

et al. 2021

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Shin'iseihaito (Xinyiqingfeitang) is a formula of traditional Japanese Kampo medicine and traditional Chinese medicine (TCM) and for chronic sinusitis. However, the precise action mechanism has been unknown. We examined the effect of shin'iseihaito extract (SSHT) on murine allergic rhinitis model using ovalbumin (OVA). We decocted the mixture of 9 crude drugs in water to prepare SSHT. SSHT (20 times amount of human dose) was orally administered to mice treated with OVA. After mice were sacrificed on day 28, immunoglobulin (Ig) E, interleukin (IL)-4, IL-13, interferon (IFN)-γ, and thymic stromal lymphopoietin (TSLP) levels in nasal lavage fluid samples were measured by enzyme-linked immunosorbent assay (ELISA). The pathological tissue sections from the nasal epithelial mucosa were histopathologically investigated by optical and scanning electron microscopies. We also investigated the effects of modified SSHTs prepared by removing one crude drug from shin'iseihaito to clarify the active ingredients. SSHT suppressed IgE, IL-4, IL-13, and TSLP levels, while increased the IFN-γ levels in OVA-induced allergic mice. Sensitization with OVA resulted in an increase in eosinophilia and goblet cells in murine nasal cavity tissue in comparison with those in untreated group, however, those were significantly reduced by the treatment with SSHT. The extracts of 8 crude drug's mixtures except for the removal of Gypsum fibrosum (GF) from

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Pharmacological Characteristics of Ryokan-kyomi-shinge-nin-to, an Antiallergic Kampo Medicine.

Cited by 9 publications

References 19 publications

Japanese traditional medicine, Senn-kinn-naidaku-sann up-regulates Toll-like receptor 4 and reduces murine allergic rhinitis

Japanese traditional medicine, Senn-kinn-naidaku-sann up-regulates Toll-like receptor 4 and reduces murine allergic rhinitis

Complementary Therapies in Allergic Rhinitis

Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines

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