Pharmacological characterization and autoradiographic localization of dopamine D1 receptors in the human umbilical artery

Ferreira-de-Almeida, J; Pereira-Leite, L.; Cavallotti, Carlo; Rícci, Alberto; Amenta, Francesco

doi:10.1016/0014-2999(93)90955-h

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…Afterwards, there was a spate of activity leading to the uncovering of multiple D 1 -like transcripts in different organisms. Thus, current evidence indicates that D 1 -like receptors are expressed in diverse species, including the fruit fly (Gotzes et al, 1994; Sugamori et al, 1995; Han et al, 1996; Reale et al, 1997; Schetz et al, 2003; Kehren and Baumann, 2005), cockroach (Orr et al, 1987; Evans et al, 1991; Evans and Green, 1991), locust (Homberg, 2002; Keating and Orchard, 2004), spider (Schmidt et al, 1981; Sauer et al, 1994), eel (Cardinaud et al, 1997), earthworm (Gardner and Cashin, 1975; Shpakov et al, 2008), flatworm (Venturini et al, 1989), goldfish (Mora-Ferrer et al, 1999), tree frog, (Agui et al, 1988; Schutte, 1991; Liu and Lasater, 1994; Behrens and Wagner, 1995) lizard (Clark et al, 2000), chicken (Agui et al, 1988; Demchyshyn et al, 1995; Schnabel et al, 1997; Sun and Reiner, 2000; Soares et al, 2000; Kubrusly et al, 2007), rodent (Grilli et al, 1988; Nisoli et al, 1988; Tiberi et al, 1991; Bryson et al, 1992; Mannoury la Cour et al, 2007), monkey (Besson et al, 1988; Sedvall et al, 1991; Choi et al, 1995; Bergson et al, 1995a; Bergson et al, 1995b) and humans (De Keyser et al, 1988a; De Keyser et al, 1988b; Dearry et al, 1990; Sunahara et al, 1990; Sidhu and Fishman, 1990; Grandy et al, 1990; Weinshank et al, 1991; Ferreira-de-Almeida et al, 1993). Among these species, multiple structurally divergent subtypes of D 1 -like receptors have been detected, including at least 3 transcripts in Xenopus (D 1A , D 1B and D 1C ), 4 in the chicken (D 1A , D 1B , D 1C and D 1D ), 2 in the mouse or rat (D 1A and D 1B ), 2 in the monkey, and 2 in humans (D 1 and D 5 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacology of signaling induced by dopamine D1-like receptor activation

Undieh

2010

Pharmacology & Therapeutics

110

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Dopamine D1-like receptors consisting of D1 and D5 subtypes are intimately implicated in dopaminergic regulation of fundamental neurophysiologic processes such as mood, motivation, cognitive function, and motor activity. Upon stimulation, D1-like receptors initiate signal transduction cascades that are mediated through adenylyl cyclase or phosphoinositide metabolism, with subsequent enhancement of multiple downstream kinase cascades. The latter actions propagate and further amplify the receptor signals, thus predisposing D1-like receptors to multifaceted interactions with various other mediators and receptor systems. The adenylyl cyclase response to dopamine or selective D1-like receptor agonists is reliably associated with the D1 subtype, while emerging evidence indicates that the phosphoinositide responses in native brain tissues may be preferentially mediated through stimulation of the D5 receptor. Besides classic coupling of each receptor subtype to specific G proteins, additional biophysical models are advanced in attempts to account for differential subcellular distribution, heteromolecular oligomerization, and activity-dependent selectivity of the receptors. It is expected that significant advances in understanding of dopamine neurobiology will emerge from current and anticipated studies directed at uncovering the molecular mechanisms of D5 coupling to phosphoinositide signaling, the structural features that might enhance pharmacological selectivity for D5 versus D1 subtypes, the mechanism by which dopamine may modulate phosphoinositide synthesis, the contributions of the various responsive signal mediators to D1 or D5 interactions with D2-like receptors, and the spectrum of dopaminergic functions that may be attributed to each receptor subtype and signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Pharmacology of signaling induced by dopamine D1-like receptor activation

Undieh

2010

Pharmacology & Therapeutics

110

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“…In the present study we have used samples of the placental (maternal) end of the umbilical artery, which represents the portion of the artery richest in dopamine DI-like sites (Ferreira de Almeida et al, 1993). We have observed that the density of dopamine Dl-like receptor sites is reduced in the umbilical artery of preeclamptic patients.…”

Section: Resultsmentioning

confidence: 97%

“…It has been shown that dopamine vasodilates the human umbilical artery by interacting with DI-like (formerly defined as DAJ receptors (Hughes & Sever, 1987). Moreover, the existence of D1-like receptors has been recently demonstrated by radioligand binding and autoradiographic techniques (Ferreira de Almeida, Perreira-Leite, Cavallotti, Ricci & Amenta, 1993). The present study was designed to assess the pharmacological characteristics and localization of dopamine DI-like receptors in the umbilical artery in pre-eclampsia.…”

Section: Introductionmentioning

confidence: 96%

Loss of dopamine D₁‐like receptors in the umbilical artery of pre‐eclamptic subjects

Almeida¹,

Cavallotti

Leite

et al. 1994

Journal of Autonomic Pharmacology

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1. The influence of pre-eclampsia on the density and pattern of dopamine D1-like receptors was studied in frozen samples of the placental end of the umbilical artery by using radioligand binding and autoradiographic techniques in combination. 2. Analysis was performed on normotensive (n = 10) and pre-eclamptic subjects (n = 9) undergoing caesarean delivery, using [3H]-SCH 23390 as a ligand. Pre-eclamptic patients received a low salt diet and were treated with magnesium sulphate and hydralazine. The possibility that this treatment may cause changes in the density of dopamine D1-like receptors was evaluated by treating male Wistar rats in the same way and by determining [3H]-SCH 23390 binding in sections of the kidney which represents an organ containing dopamine D1-like receptors. 3. The density of dopamine D1-like receptors of the umbilical artery, which are probably vasodilatory, was decreased in pre-eclamptic compared with normotensive subjects. In contrast, the affinity of the radioligand for dopamine D1-like receptors was not statistically different between normotensive and pre-eclamptic subjects. Low salt diet, magnesium sulphate and hydralazine treatment did not affect [3H]-SCH 23390 binding to sections of rat kidney. This suggests that changes in the density of dopamine D1-like receptors in pre-eclamptic patients are a specific phenomenon not dependent upon antihypertensive measures. 4. Analysis of the pharmacological profile of [3H]-SCH 23390 binding to sections of the umbilical artery both in normotensive and pre-eclamptic subjects indicates the labelling of dopamine D5 receptors. 5. These findings collectively suggest that the dopaminergic vasodilatory tone in the umbilical artery is impaired in pre-eclampsia. The possible significance of these data should be clarified in future studies.

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“…Previous data has shown that human umbilical arteries also exhibit different pharmacological responses from those of vessels of other organs . The contractile adrenoreceptors in the human umbilical artery smooth musculature comprise α‐adrenoceptors (α1‐ and α2‐subtypes) and D1 receptors . On the other hand, in umbilical veins, both functional β‐ and α2‐adrenoreceptors are absent, and the α1‐receptors are responsible for the vasoconstrictor effects of catecholamines in the human umbilical vein .…”

Section: Introductionmentioning

confidence: 98%

“…5 The contractile adrenoreceptors in the human umbilical artery smooth musculature comprise α-adrenoceptors (α1-and α2-subtypes) and D1 receptors. 6,7 On the other hand, in umbilical veins, both functional βand α2-adrenoreceptors are absent, and the α1-receptors are responsible for the vasoconstrictor effects of catecholamines in the human umbilical vein. 8 Contractions evoked by α1and α2-adrenergic agonists are augmented by removal of the endothelium, by inhibitors of nitric oxide synthase, or both.…”

Section: Introductionmentioning

confidence: 99%

Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

Gunduz

Arun

Bagci

et al. 2014

J of Obstet and Gynaecol

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Dopamine, adrenaline and noradrenaline elicit contractions in human umbilical arteries, and noradrenaline causes the highest contraction. Both propofol and sevoflurane inhibit these contractions in a dose-dependent manner. Propofol caused greater relaxation in the contractions elicited by dopamine and adrenaline while sevoflurane caused greater relaxation in the contraction elicited by noradrenaline.

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Pharmacological characterization and autoradiographic localization of dopamine D1 receptors in the human umbilical artery

Cited by 13 publications

References 21 publications

Pharmacology of signaling induced by dopamine D1-like receptor activation

Pharmacology of signaling induced by dopamine D1-like receptor activation

Loss of dopamine D₁‐like receptors in the umbilical artery of pre‐eclamptic subjects

Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

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Pharmacological characterization and autoradiographic localization of dopamine D1 receptors in the human umbilical artery

Cited by 13 publications

References 21 publications

Pharmacology of signaling induced by dopamine D1-like receptor activation

Pharmacology of signaling induced by dopamine D1-like receptor activation

Loss of dopamine D1‐like receptors in the umbilical artery of pre‐eclamptic subjects

Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

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Loss of dopamine D₁‐like receptors in the umbilical artery of pre‐eclamptic subjects