Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon

Morton, Magda F.; Welsh, N J; Tavares, Ignatius A.; Shankley, Nigel P.

doi:10.1016/s0167-0115(01)00383-4

Cited by 22 publications

(21 citation statements)

References 10 publications

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“…58,60 CCK 1 receptors are G-protein coupled receptors that activate G q and polyphospoinosotide hydrolysis, generation of diacylglycerol and inositol triphosphate and increases in intracellular calcium (Varga et al 59 ). 59 CCK 1 receptor agonists stimulate gastrointestinal smooth muscle contraction by acting directly at CCK receptor on smooth muscle and enteric nerves.…”

Section: Cck 1 Receptor Structure and Functionmentioning

confidence: 99%

Basic and clinical pharmacology of new motility promoting agents

Galligan

Vanner

2005

Neurogastroenterology Motil

117

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Recent research has provided new information about drugs that could be used to treat functional motility disorders. Promotility drugs accelerate gastric emptying or colonic transit and these properties may contribute to their efficacy in treating symptoms associated with gastroparesis, functional dyspepsia or constipation. 5-Hydroxytryptamine4 receptors are targets for drugs (tegaserod, renzapride) that treat symptoms in constipated irritable bowel syndrome patients and in gastroparesis. Drugs acting at motilin (erythromycin) and cholecystokinin-1 (dexloxiglumide) receptors accelerate gastric emptying. Dexloxiglumide might be useful in the treatment of functional dyspepsia particularly that associated with lipid intake. Alvimopan is a mu-opioid receptor antagonist that does not cross the blood brain barrier. Alvimopan is effective in treating postsurgical ileus and perhaps opiate-induced bowel dysfunction. Successes and failures of recent efforts to develop promotility agents revealed opportunities and challenges for developing new promotility drugs. The pharmacological properties of partial agonists might be exploited to develop effective promotility drugs. However, opposing actions of promotility agents on motility (increased contraction vs decreased accommodation) limit the clinical efficacy of drugs with these opposing actions. Selection of appropriate patient populations for evaluation of new drugs is also critical.

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Section: Cck 1 Receptor Structure and Functionmentioning

confidence: 99%

Basic and clinical pharmacology of new motility promoting agents

Galligan

Vanner

2005

Neurogastroenterology Motil

117

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“…It has recently been found to be involved in the modulation of GI tract motility (Varga et al, 2004). Administration of CCK promotes colonic motor response in healthy guinea pig, and in the ascending colon in human (Morton et al, 2002; Zhu et al, 2010). Our results show that CCK expression from the distal colon was elevated in NMS rats.…”

Section: Discussionmentioning

confidence: 99%

Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome

Tjong

Lao

et al. 2011

Journal of Ethnopharmacology

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Aim of study Coptis chinensis rhizomes (Coptidis Rhizoma, CR), also known as “Huang Lian”, is a common component of traditional Chinese herbal formulae used for the relief of abdominal pain and diarrhea. Yet, the action mechanism of CR extract in the treatment of irritable bowel syndrome is unknown. Thus, the aim of our present study is to investigate the effect of CR extract on neonatal maternal separation (NMS)-induced visceral hyperalgesia in rats and its underlying action mechanisms. Materials and methods Male Sprague-Dawley rats were subjected to 3-hr daily maternal separation from postnatal day 2 to day 21 to form the NMS group. The control group consists of unseparated normal (N) rats. From day 60, rats were administrated CR (0.3, 0.8 and 1.3 g/Kg) or Vehicle (Veh; 0.5% carboxymethylcellulose solution) orally for 7 days for the test and control groups, respectively. Results Electromyogram (EMG) signals in response to colonic distension were measured with the NMS rats showing lower pain threshold and increased EMG activity than those of the unseparated (N) rats. CR dose-dependently increased pain threshold response and attenuated EMG activity in the NMS rats. An enzymatic immunoassay study showed that CR treatment significantly reduced the serotonin (5HT) concentration from the distal colon of NMS rats compared to the Veh (control) group. Real-time quantitative PCR and Western-blotting studies showed that CR treatment substantially reduced NMS induced cholecystokinin (CCK) expression compared with the Veh group. Conclusions These results suggest that CR extract robustly reduces visceral pain that may be mediated via the mechanism of decreasing 5HT release and CCK expression in the distal colon of rats.

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“…Human CCK 1 receptors, which can bring about CCK-induced contractions in colonic circular smooth muscle, have previously been shown to be stimulated by pentagastrin [230]. This would suggest that circulating gastrin will also bring about contraction within the colonic smooth muscle.…”

Section: Control Of Colonic Motilitymentioning

confidence: 98%

The Interaction of Dietary Fibres with the Colon

Dettmar¹,

Strugala²,

Pearson³

2006

CNF

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The term dietary fibre describes a wide range of highly divergent (mainly polysaccharide) compounds that escape digestion before the colon. Fibre is often regarded as a neutral dietary compound, not interacting with the gut and only offering dietary "benefit" by the consequent absence of calorific macronutrients, or by bulking out luminal content.Although the above benefits are apparent, a number of other physiological effects of dietary fibres in the colon have previously been described. This review outlines these previous observations in terms of the effect of various fibre types on (i) colonic luminal contents (including the resident microflora (ii) the first line of colonic protection, the mucus barrier (iii) the underlying colonic mucosa (iv) the colonic musculature and (v) colonic neurohumoural release, and the subsequent effect on control of gut motility and satiety. This review will further highlight the divergent physiological effects of various fibre types, and their potential health benefits.

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Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon

Cited by 22 publications

References 10 publications

Basic and clinical pharmacology of new motility promoting agents

Basic and clinical pharmacology of new motility promoting agents

Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome

The Interaction of Dietary Fibres with the Colon

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