Pharmacological characterization of rat paw edema induced by Naja haje arabica venom

Abstract

ABSTRACT:This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The Commercially available antivenom was ineffective when administered intravenously, whereas its local administration with NhaV attenuated the edema formation (P<0.001). In conclusion, NhaV-induced edema in rat paw involves PLA 2 and adenosine mechanisms. Additionally, the use of polyspecific antivenom, intravenously, was ineffective in preventing NhaV-induced edema.KEY WORDS: rat paw edema, Naja haje arabica venom, inflammatory mediators, inhibitor, antivenom.