Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom

In vitro hemolytic activity of Bothrops lanceolatus (fer-de-lance) venom

“…Incubation of the venom at different temperatures indicated that the venom component responsible for hemolysis is thermolabile. Other biological activities of B. lanceolatus, such as rat paw edema, leukocyte migration and hemorrhagic activity, are also thermolabile (7,21,22 (16,(28)(29)(30)(31)(32).…”

Effect of dexamethasone associated with serum therapy on treatment of Bothrops jararaca venom-induced paw edema in mice

“…A major participation of metabolites of arachidonic acid in the evolution of paw edema induced by Bothrops venoms has been reported [7][8][9][14][15][16]. Thus, associating anti-infl ammatory drugs, such as dexamethasone or indomethacin, with antivenom should be a rational alternative to treat the local reaction provoked by Bothrops venoms.…”

“…The participation of leukotrienes in the infl ammatory reaction induced by Bothrops venoms has already been investigated [7,8,14,22,23]. It was observed that zileuton could inhibit B. jararaca-induced edema when administered up to 15 min after venom administration.…”

“…Some studies have shown that pretreatment of animals with anti-infl ammatory drugs can result in a signifi cant reduction of Bothrops venom-induced paw edema [7][8][9][14][15][16]. Despite such evidences, the use of anti-infl ammatory drugs in combination with serum therapy is not a usual practice to treat patients bitten by Bothrops snakes in Brazil [17].…”

Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema

“…Leukocyte infiltration also occurs and, at high doses of venom, there is local hemorrhage [3]. Heating B. lanceolatus venom abolishes the hemorrhagic activity and significantly reduces the edematogenic effect, suggesting the involvement of a thermolabile hemorrhagic principle(s) with a capacity to induce edema [29].…”