Pharmacological comparison of the rat and guinea-pig cortical high affinity 5-hydroxytryptamine uptake system

Hornsby, C. D.; Barnes, James L.; Barnes, Nicholas M.; Champaneria, Shashi; Costall, B.; Naylor, R.J.

doi:10.1016/0006-2952(92)90723-v

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Nortriptyline Effects On 5-ht 1b Mrna1

Determination Of Neurotransmitters Uptake In Synaptosomes1

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Cited by 6 publications

(2 citation statements)

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“…Nortriptyline is a TCA with only modest affinity for rat serotonin transporter (Hornsby et al, 1992); this class of drugs has been previously associated with increased postsynaptic 5-HT 1A function in hippocampus (Chaput et al, 1991). TCA effects on 5-HT 1B receptor mRNA have not been previously reported.…”

Section: Nortriptyline Effects On 5-ht 1b Mrnamentioning

confidence: 99%

Antidepressant-induced regulation of 5-HT1b mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation

2000

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Section: Nortriptyline Effects On 5-ht 1b Mrnamentioning

confidence: 99%

Antidepressant-induced regulation of 5-HT1b mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation

2000

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“…Crude synaptosomes were prepared according to Hornsby et al [7]. The protein contents of the samples were measured using the method of Lowry.…”

Section: Determination Of Neurotransmitters Uptake In Synaptosomesmentioning

confidence: 99%

Overexpression of γ-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice

Zhao

et al. 2001

Cell Res

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γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, and the GABAergic synaptic transmission is normally terminated by the rapid uptake through GABA transporters. With transgenic mice ubiquitously overexpressing GABA transporter subtype I (GAT1), the present study explored the pathophysiological role of GAT1 in epileptogenesis. Though displaying no spontaneous seizure activity, these mice exhibit altered electroencephalographic patterns and increased susceptibility to seizure induced by kainic acid. In addition, the GABA A receptor and glutamate transporters are up-regulated in transgenic mice, which perhaps reflects a compensatory or corrective change to the elevated level of GAT1. These preliminary findings support the hypothesis that excitatory and inhibitory neurotransmission, and seizure susceptibility can be altered by neurotransmitter transporters.

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The olfactory bulbectomy model in mice and rat: One story or two tails?

Hendriksen

Korte

Olivier

et al. 2015

European Journal of Pharmacology

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Pharmacological comparison of the rat and guinea-pig cortical high affinity 5-hydroxytryptamine uptake system

Cited by 6 publications

References 18 publications

Antidepressant-induced regulation of 5-HT1b mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation

Antidepressant-induced regulation of 5-HT1b mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation

Overexpression of γ-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice

The olfactory bulbectomy model in mice and rat: One story or two tails?

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