Pharmacological compounds targeting emotional cognition in alcohol use disorder: A systematic review

Mistarz, Nicolaj; Andersen, Kjeld; Nielsen, Anette Søgaard; Goudriaan, Anna E.; Michel, Tanja Maria; Skøt, Lotte; Anhøj, Simon; Mellentin, Angelina Isabella

doi:10.1016/j.pnpbp.2022.110535

Progress in Neuro-Psychopharmacology and Biological Psychiatry

2022

DOI: 10.1016/j.pnpbp.2022.110535

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Pharmacological compounds targeting emotional cognition in alcohol use disorder: A systematic review

Nicolaj Mistarz

Kjeld Andersen

Anette Søgaard Nielsen

et al.

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Cited by 2 publications

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Role of glycogen synthase kinase-3β in dependence and abuse liability of alcohol

Oka,

Yoshino,

Kitanaka

et al. 2023

Alcohol and Alcoholism

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Background Alcohol is a major abused drug worldwide that contributes substantially to health and social problems. These problems result from acute alcohol overuse as well as chronic use, leading to alcohol use disorder (AUD). A major goal of this field is to establish a treatment for alcohol abuse and dependence in patients with AUD. The central molecular mechanisms of acute alcohol actions have been extensively investigated in rodent models. Aims One of the central mechanisms that may be involved is glycogen synthase kinase-3β (GSK-3β) activity, a key enzyme involved in glycogen metabolism but which has crucial roles in numerous cellular processes. Although the exact mechanisms leading from acute alcohol actions to these chronic changes in GSK-3β function are not yet clear, GSK-3β nonetheless constitutes a potential therapeutic target for AUD by reducing its function using GSK-3β inhibitors. This review is focused on the correlation between GSK-3β activity and the degree of alcohol consumption. Methods Research articles regarding investigation of effect of GSK-3β on alcohol consumption in rodents were searched on PubMed, Embase, and Scopus databases using keywords “glycogen synthase kinase,” “alcohol (or ethanol),” “intake (or consumption),” and evaluated by changes in ratios of pGSK-3βSer9/pGSK-3β. Results In animal experiments, GSK-3β activity decreases in the brain under forced and voluntary alcohol consumption while GSK-3β activity increases under alcohol-seeking behavior. Conclusions Several pieces of evidence suggest that alterations in GSK-3β function are important mediators of chronic ethanol actions, including those related to alcohol dependence and the adverse effects of chronic ethanol exposure.

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Role of glycogen synthase kinase-3β in dependence and abuse liability of alcohol

Oka,

Yoshino,

Kitanaka

et al. 2023

Alcohol and Alcoholism

View full text Add to dashboard Cite

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Von Economo Neuron Involvement in Social Cognitive and Emotional Impairments in Neuropsychiatric Disorders

Lopez-Ojeda

Hurley

2022

JNP

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Pharmacological compounds targeting emotional cognition in alcohol use disorder: A systematic review

Cited by 2 publications

References 52 publications

Role of glycogen synthase kinase-3β in dependence and abuse liability of alcohol

Role of glycogen synthase kinase-3β in dependence and abuse liability of alcohol

Von Economo Neuron Involvement in Social Cognitive and Emotional Impairments in Neuropsychiatric Disorders

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